Karen Kristine Sørensen
Stillingsbeskrivelse
Forskning og undervisning.
Javier Sánchez Romano,
Jaione Simon-Santamaria,
Peter Anthony McCourt,
Bård Helge Smedsrød,
Kim Erlend Mortensen,
Antonia Sagona
m.fl.:
Liver sinusoidal cells eliminate blood-borne phage K1F
Sabin Bhandari,
Ingelin Kyrrestad Karlstrøm,
Jaione Simon-Santamaria,
Ruomei Li,
Karolina Joanna Szafranska,
Gianina Aurica Dumitriu
m.fl.:
Mouse liver sinusoidal endothelial cell responses to the glucocorticoid receptor agonist dexamethasone
Frontiers in Pharmacology 2024 DOI
Ingelin Kyrrestad Karlstrøm,
Anett Kristin Larsen,
Javier Sanchez Romano,
Jaione Santamaria Simon,
Ruomei Li,
Karen Kristine Sørensen
:
Infection of liver sinusoidal endothelial cells with Muromegalovirus muridbeta1 involves binding to neuropilin-1 and is dynamin-dependent
Milton Boaheng Antewi,
Gianina Aurica Dumitriu,
Jaione Santamaria Simon,
Javier Sanchez Romano,
Ruomei Li,
Bård Smedsrød
m.fl.:
Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIb, yet maintain a preserved fenestration in the Glmp gt/gt mouse model of slowly progressing liver fibrosis
Ruomei Li,
Sabin Bhandari,
Inigo Zubiavrre Martinez,
Jack-Ansgar Bruun,
Ilona Halva Urbarova,
Bård Smedsrød
m.fl.:
Changes in the proteome and secretome of rat liver sinusoidal endothelial cells during early primary culture and effects of dexamethasone
Anett Kristin Larsen,
Jaione Simon-Santamaria,
kjetil helge Elvevold,
Bo Gøran Ericzon,
Kim Erlend Mortensen,
Peter Anthony McCourt
m.fl.:
Autofluorescence in freshly isolated adult human liver sinusoidal cells
Sabin Bhandari,
Anett Kristin Larsen,
Peter Anthony McCourt,
Bård Smedsrød,
Karen Kristine Sørensen
:
The scavenger function of liver sinusoidal endothelial cells in health and disease
Karen Kristine Sørensen,
Bård Smedsrød
:
The Liver Sinusoidal Endothelial Cell: Basic Biology and Pathobiology
John Wiley & Sons 2020
Sabin Bhandari,
Ruomei Li,
Jaione Simon-Santamaria,
Peter Anthony McCourt,
Steinar Daae Johansen,
Bård Smedsrød
m.fl.:
Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages
Cristina Ionica Øie,
Deanna Wolfson,
Tanji Yasunori,
Gianina Dumitriu,
Karen Kristine Sørensen,
Peter Anthony McCourt
m.fl.:
Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses.
Javier Sanchez Romano,
Karen Kristine Sørensen,
Anett Kristin Larsen,
Torill Mørk,
Morten Tryland
:
Ocular Histopathological Findings in Semi-Domesticated Eurasian Tundra Reindeer (Rangifer tarandus tarandus) with Infectious Keratoconjunctivitis after Experimental Inoculation with Cervid Herpesvirus 2
Bo Wold Nilsen,
Jaione Simon-Santamaria,
Ulf Thore Ørtengren,
Einar Jensen,
Jack-Ansgar Bruun,
Vibeke Barman Michelsen
m.fl.:
Dose- and time-dependent effects of triethylene glycol dimethacrylate on the proteome of human THP-1 monocytes
Anett Kristin Larsen,
Ingebjørg Helena Nymo,
Karen Kristine Sørensen,
Marit Seppola,
Rolf Rødven,
María Pilar Jiménez de Bagüés
m.fl.:
Concomitant Temperature Stress and Immune Activation may Increase Mortality Despite Efficient Clearance of an Intracellular Bacterial Infection in Atlantic Cod
Morten Tryland,
Javier Sanchez Romano,
Nina Marcin,
Ingebjørg Helena Nymo,
Terje D. Josefsen,
Karen Kristine Sørensen
m.fl.:
Cervid herpesvirus 2 and not Moraxella bovoculi caused keratoconjunctivitis in experimentally inoculated semi-domesticated Eurasian tundra reindeer
Bo Wold Nilsen,
Ulf Thore Ørtengren,
Jaione Simon-Santamaria,
Karen Kristine Sørensen,
Vibeke Barman Michelsen
:
Methods and terminology used in cell-culture studies of low-dose effects of matrix constituents of polymer resin-based dental materials
European Journal of Oral Sciences 2016 DOI
Karen Kristine Sørensen,
Jaione Simon-Santamaria,
Robert S. McCuskey,
Bård Smedsrød
:
Liver sinusoidal endothelial cells
Comprehensive Physiology 2015 DOI
Emma L. Shepherd,
Ellie Northall,
Pantelitsa Papakyriacou,
Karolina Safranska,
Karen Kristine Sørensen,
Patricia F. Lalor
:
Decellularization of the Human Liver to Generate Native Extracellular Matrix for Use in Automated Functional Assays with Stellate Cells
Methods in molecular biology 2023 DOI
Ingelin Kyrrestad Karlstrøm,
Anett Kristin Larsen,
Javier Sanchez Romano,
Jaione Santamaria Simon,
Ruomei Li,
Karen Kristine Sørensen
:
The dynamin-inhibitor dynasore blocks cytomegalovirus infection in primary mouse liver sinusoidal endothelial cells
2023
Javier Sanchez Romano,
Jaione Santamaria Simon,
Peter Anthony Gerard Mccourt,
Christopher Florian Holte,
Bård Smedsrød,
Antonia Sagona
m.fl.:
Rapid blood clearance of phage K1F-GFP is mediated by the liver and executed by Kupffer cells and liver sinusoidal endothelial cells in collaboration
2023
Anett Kristin Larsen,
Javier Sanchez Romano,
Jaione Santamaria Simon,
Kim Erlend Mortensen,
Ingelin Kyrrestad Karlstrøm,
Eirik Abrahamsen Lænsman
m.fl.:
Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream.
Journal of Hepatology 2023 DOI
Ingelin Kyrrestad Karlstrøm,
Anett Kristin Larsen,
Javier Sanchez Romano,
Jaione Santamaria Simon,
Ruomei Li,
Karen Kristine Sørensen
:
Dynamin-inhibitors dynasore and MitMAB block muromegalovirus muridbeta1 infection in liver sinusoidal endothelial cells.
2023
Ingelin Kyrrestad,
Javier Sanchez Romano,
Anett Kristin Larsen,
Ruomei Li,
Jaione Simon-Santamaria,
Kenneth Bowitz Larsen
m.fl.:
Effect of dynamin inhibitor dynasore on primary mouse liver sinusoidal endothelial cells (LSEC)
2022
Javier Sanchez Romano,
Anett Kristin Larsen,
Jaione Simon-Santamaria,
Cristina Ionica Øie,
Bård Smedsrød,
Peter Anthony McCourt
m.fl.:
The role of scavenger endothelial cells in bacteriophage pharmacokinetics
2022
Javier Sanchez Romano,
Anett Kristin Larsen,
Jaione Simon-Santamaria,
Cristina Ionica Øie,
Bård Smedsrød,
Peter Anthony McCourt
m.fl.:
The role of scavenger endothelial cells in bacteriophage pharmacokinetics
2022
Anett Kristin Larsen,
Javier Sanchez Romano,
Jaione Simon-Santamaria,
Kim Erlend Mortensen,
Bo Gøran Ericzon,
Peter Anthony McCourt
m.fl.:
Role of liver sinusoidal endothelial cells in elimination of virus
2022
Anett Kristin Larsen,
Javier Sanchez Romano,
Eirik Abrahamsen Lænsman,
Anne Lotte Vada Hatlegjerde,
Jaione Simon-Santamaria,
Kim Erlend Mortensen
m.fl.:
Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream
2022
Javier Sanchez Romano,
Morten Tryland,
Ingebjørg Helena Nymo,
Anett Kristin Larsen,
Karen Kristine Sørensen
:
Infectious keratoconjunctivitis in reindeer - The role of the reindeer alphaherpesvirus
UiT Norges arktiske universitet 2019
Karen Kristine Sørensen,
Milton Boaheng Antwi,
Gianina Dumitriu,
Ruomei Li,
Bård Smedsrød,
Winnie Eskild
:
Scavenger function of liver sinusoidal endothelial cells in a transgenic mouse model of liver fibrosis is reduced
2019
Sabin Bhandari,
Ruomei Li,
Ingelin Kyrrestad,
Jack-Ansgar Bruun,
Ilona Urbarova,
Bård Smedsrød
m.fl.:
Effect of glucocorticoids on liver sinusoidal endothelial cells in vitro
2019
Ingelin Kyrrestad,
Ruomei Li,
Sabin Bhandari,
Jaione Simon-Santamaria,
Bård Smedsrød,
Karen Kristine Sørensen
:
A protocol for in vitro toxicity studies in liver sinusoidal endothelial cells
2019
Anett Kristin Larsen,
Jaione Simon-Santamaria,
kjetil helge Elvevold,
Bo G. Ericzon,
Bård Smedsrød,
Karen Kristine Sørensen
:
Autofluorescence in freshly isolated adult human liver sinusoidal cells
2019
Javier Sanchez Romano,
Anett Kristin Larsen,
kjetil helge Elvevold,
Christopher Florian Holte,
Jaione Simon-Santamaria,
Hans H. Hirsch
m.fl.:
SECVIR - The role of scavenger endothelial cells in elimination of virus
2019
Javier Sanchez Romano,
Karen Kristine Sørensen,
Ingebjørg Helena Nymo,
Torill Mørk,
Morten Tryland
:
Histopathological study of eye tissues from semi-domesticated reindeer with infectious keratoconjunctivitis caused by cervid herpesvirus 2 in an experimental setting
2018
Deanna Wolfson,
Cristina Ionica Øie,
Tanji Yasunori,
Gianina Dumitriu,
Peter Anthony McCourt,
Karen Kristine Sørensen
m.fl.:
Uptake and Degradation of Bacteriophages
by Liver Sinusoidal Endothelial Cells
2018 ARKIV
Deanna Wolfson,
Cristina Ionica Øie,
Yasunori Tanji,
Karen Kristine Sørensen,
Peter Anthony McCourt,
Bård Smedsrød
m.fl.:
Multimodal Microscopy to Study the Fate of Bacteriophages in Liver Sinusoidal Endothelial Cells
2017
Javier Sanchez Romano,
Morten Tryland,
John A. Angelos,
Torill Mørk,
Ingebjørg Helena Nymo,
Karen Kristine Sørensen
:
The pathogenic role of Moraxella bovoculi in infectious keratoconjunctivitis in semi-domesticated reindeer
2017
Sabin Bhandari,
Ruomei Li,
Jaione Simon-Santamaria,
Peter Anthony McCourt,
Steinar Daae Johansen,
Bård Smedsrød
m.fl.:
The liver sinusoidal endothelial cell – an endothelial cell with a macrophage-like identity
2017
Ruomei Li,
Jaione Simon-Santamaria,
Sabin Bhandari,
Jack-Ansgar Bruun,
Ilona Urbarova,
Bård Smedsrød
m.fl.:
Phenotypic changes in rat liver sinusoidal endothelial cells during early stages of in vitro culture
2017
Hong Mao,
Cristina Ionica Øie,
Ruomei Li,
Ana Oteiza,
Karen Kristine Sørensen,
Deanna Wolfson
m.fl.:
Disruption of rat liver sinusoidal endothelial cell morphology by oxidised low density lipoproteins
2017
Hong Mao,
Cristina Ionica Øie,
Ruomei Li,
Ana Oteiza,
Karen Kristine Sørensen,
Deanna Wolfson
m.fl.:
Using super-resolution microscopy to image disruption of liver sinusoidal endothelial cell morphology by oxidized low-density lipoproteins
2017
Peter Anthony McCourt,
Ana Oteiza,
Melonie J. Storan,
Brenda Williams,
Chad K. Heazlewood,
Karen Kristine Sørensen
m.fl.:
Identification of adult hemogenic sinusoidal endothelial cells in adult bone marrow.
2016
Hong Mao,
Cristina Ionica Øie,
Ruomei Li,
Ana Oteiza,
Karen Kristine Sørensen,
Deanna Wolfson
m.fl.:
Disruption of liver sinusoidal endothelial cell morphology by oxidized low–density lipoproteins
2016
Bo Wold Nilsen,
Ulf Thore Ørtengren,
Jaione Simon-Santamaria,
Karen Kristine Sørensen,
Vibeke Barman Michelsen
:
Low-grade toxicity of matrix constituents of polymer resin based dental materials - A review of terminology and methods
2016
Jaione Simon-Santamaria,
Ruomei Li,
Sabin Bhandari,
Jack-Ansgar Bruun,
Bård Smedsrød,
Inigo Zubiavrre Martinez
m.fl.:
Secretome of the liver sinusoidal endothelial cell
2016
Sabin Bhandari,
Ruomei Li,
Jaione Simon-Santamaria,
Peter Anthony McCourt,
Steinar Daae Johansen,
Bård Smedsrød
m.fl.:
Next generation deep sequencing of rat liver
sinusoidal endothelial cell and Kupffer cell
transcriptomes suggests functional
complementarity
2016
Morten Tryland,
Javier Sanchez Romano,
Nina Marcin,
Karen Kristine Sørensen,
Ingebjørg Helena Nymo,
Terje D. Josefsen
m.fl.:
The cause of infectious keratoconjunctivitis in semi-domesticated reindeer - an experimental approach
2015
Morten Tryland,
Javier Sanchez Romano,
Nina Marcin,
P Kiær,
OC Kjenstad,
Torill Mørk
m.fl.:
Reindeer alphaherpesvirus (CvHV2) and not Moraxella bovoculi caused infectious keratoconjunctivitis experimentally in semi-domesticated reindeer (Rangifer tarandus tarandus)
2015
Javier Sanchez Romano,
Morten Tryland,
Ingebjørg Helena Nymo,
Torill Mørk,
Terje D. Josefsen,
Karen Kristine Sørensen
:
Severe transmissible eye infection in reindeer: bacterium or virus?
2015
Peter Anthony McCourt,
Thomas Rolf Huser,
Karen Kristine Sørensen,
Cristina Ionica Øie,
Viola Mönkemöller,
Balpreet Singh Ahluwalia
:
Optical microscopy to reveal structural and functional properties of liver cells.
2015
Jaione Simon-Santamaria,
Christine H Rinaldo,
Piotr Kardas,
Ruomei Li,
Ivana Malovic,
Kjetil H. Elvevold
m.fl.:
Role of scavenger endothelial cells in polyomavirus JC and BK clearance
2014
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Forskningsinteresser
- Liver sinusoidal endothelial cell (LSEC) biology
- Scavenger function of LSEC in health and disease
- Role of liver sinusoidal cells in the elimination of virus
- Comparative and developmental aspects of scavenger endothelial cells
Undervisning
Underviser i cellebiologi, fysiologi, histologi og elektronmikroskopi i emner tilknyttet utdanningene i medisin, odontologi, bioingeniør, og bachelor/master/PhD i biomedisin.
Medlem i forskningsgruppe
Medlem i prosjekt
CV
Utdanning
1989: Veterinærmedisinsk embetseksamen, Norges Veterinærhøgskole, Oslo
1999: PhD i biologi, Universitetet i Tromsø
Yrkespraksis
1989-90: Avdelingsveterinær, Næringsmiddeltilsynet i Sortland og Øksnes
1991-93: Klinisk stordyrpraksis, Leirfjord og Suldal
1994-98: NFR-stipendiat, Avdeling for arktisk veterinærmedisin, NVH, Tromsø.
1998-03: Forsker (patologi, mikrobiologi, laboratoriediagnostikk), Veterinærinstituttet Tromsø
2003-06: Postdoktor (NFR), IMB, Avdeling for cellebiologi og histologi, UiT
2005, 2007: Førsteamanuensis, vikariat, IMB, Avdeling for cellebiologi og histologi, UiT
2007-10: Postdoktor/forsker, finansiert av Tromsø forskningsstiftelse og IMB, UiT
2011-2013: Førsteamanuensis, Vaskulærbiologisk forskningsgruppe, IMB,UiT
2013- : Professor, Vaskulærbiologisk forskningsgruppe, IMB, UiT. Forskningsgruppeleder fra 2020.