Disputas – Rizwan Mohyuddin

Avhandlingen er tilgjengelig her!  The doctoral thesis! Prøveforelesning over oppgitt emne holdes kl. 10:15: “The use of therapeutic hypothermia as a mean to improve outcome in patients after cardiac arrest”. Prøveforelesningen vil bli strømmet/the trial lecture will be streamed here. Disputasen starter kl. 1215. Disputasen vil bli strømmet her.  Opptak av disputasen vil være tilgjengelig i et døgn. The defense will be streamed here. A recording of the defense will be available for 24 hours.

Populærvitenskapelig sammendrag av avhandlingen:

Severe hypothermia causes profound cardiovascular depression, leading either to hypothermic cardiac arrest or hypothermia‑induced cardiac dysfunction. Using an intact porcine model, this work shows that cooling below 32 °C consistently reduces cardiac output, stroke volume, organ perfusion, and oxygen transport. Thoracic‑lavage rewarming restored normothermia but did not fully recover cardiovascular function when spontaneous circulation persisted, nor could it re‑establish a perfusing rhythm after three hours of hypothermic cardiac arrest despite CPR. Epinephrine retained inotropic effects at moderate hypothermia, indicating potential value for circulatory support during rewarming. These findings clarify the cardiovascular pathophysiology of severe hypothermia and reinforce extracorporeal life support as the essential strategy for successful resuscitation.

Bedømmelseskomité

Professor Markus Skrifvars, Universitetet i Helsingfors – 1. opponent. 

Professor Jon-Kenneth Heltne, Universitetet i Bergen - 2. opponent. 

Professor Gunnvald Kvarstein, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder:
Førsteamanuensis Ole Martin Fuskevåg, IKM, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.