Disputas – Master in Technology Homeopathy Jana Wurz

Avhandlingen er tilgjengelig her! / The doctoral thesis is available here!

Disputasen strømmes og et opptak vil være tilgjengelig i et døgn.
The defense will be streamed, and a recording of the disputation will be available for 24 hours.


Prøveforelesning over oppgitt emne starter kl. 10.15 / The trial lecture starts at 10.15
Tittel/Title:  "When Autophagy Does Not Degrade: Mechanisms and Functions of Secretory Autophagy."
Prøveforelesningen strømmes her / The trial lecture will be streamed here.

Disputasen starter kl. 12.15 / The defense starts at 12.15.
Disputasen strømmes her / The defense will be streamed here.


Populærvitenskapelig sammendrag av avhandlingen/ Summary of the thesis:

This PhD project was focused on better understanding the protein NBR1. This protein is mainly involved in removing harmful or unnecessary substances from cells in a process called autophagy. Dysfunctional autophagy is involved in many diseases, and although it is known that NBR1 plays an important role in removing harmful substances from cells, many aspects of this autophagy process are still unknown.
Proteomics was one of the main methods used.  In this method, the experiment’s results are presented as a list of proteins that likely form a physical connection with NBR1. Junction plakoglobin (JUP) has been shown to connect to NBR1 in our proteomics study.  JUP is present in specialized structures called desmosomes, which glue neighboring cells together.
Microscope images show that NBR1 and JUP come together, and this could imply that desmosomes are broken down through the autophagy process. We also found that NBR1 moves into and out of the cell’s nucleus. One function of NBR1 in the nucleus is to get rid of toxic proteins. Another function of NBR1 in the nucleus is to help its partner protein, p62, to form functional elimination structures within the nucleus.

Veiledere/ Supervisors:
Hovedveileder/Main supervisor:
Professor Terje Johansen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

Biveileder/supervisor:
Professor Trond Lamark, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.


Bedømmelseskomité/Defensecomitee:

Professor Bjørn Stork, Institute of Molecular Medicine I, University Hospital Düsseldorf, Düsseldorf, Germany – 1. opponent.

Senior Scientist Edward Leithe, Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Norwegian Radium Hospital – 2. opponent.

Professor Kristin Andreassen Fenton, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder/ Leader of defense: 
Professor Maria Perander, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.