Disputas Master i biomedisin Muhammad Asad Akhtar

Disputasen starter kl. 11.15 kan strømmes her

Opptak av disputasen vil være tilgjengelig i et døgn.

Recordings of the trial lecture and the defense will be available for 24 hour

Prøveforelesning over oppgitt emne holdes i Auditorium 6, MH 1 kl. 09.15

"Pre- and postmenopausal use of estrogens and progestins. Benefits and risks of long-term use and possible underlying mechanisms"

Prøveforelesningen vil også bli strømmet/the trial lecture will also be streamed

Populærvitenskapelig sammendrag:

Heart disease is one of the most common causes of illness and death worldwide. After menopause, the risk of heart disease increases in women, but the reasons for this are not fully understood. This thesis studied how the female heart responds to different types of stressors after loss of ovarian function, using animal models relevant to post-menopausal cardiovascular disease.
Two main stress factors were examined: combined metabolic and high blood pressure, and a toxic stress to the heart from drugs commonly used to treat breast cancer treatments. Heart structure and function were studied using imaging methods, and changes in how the heart uses energy were studied using laboratory-based analyses.
The results show that changes in heart energy metabolism and cellular function can occur at an early stage, before clear structural damage to the heart is present. These findings contribute to a better understanding of cardiac vulnerability after menopause and suggest that early metabolic changes may be useful for identifying risk and supporting future strategies aimed at protecting the heart in women exposed to cardiovascular stress.

Hovedveileder:

Professor Anne Dragøy Hafstad, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Bi-veileder:

Associate Professor Neoma Tove Boardman, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Associate Professor Åsa Birna Birgisdottir, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Bedømmelseskomité:

Førsteamanuensis Miranda Nabben, Departments of Genetics & Cell Biology and Clinical Genetics, Maastricht university– 1. Opponent

Professor Finn Olav Levy, Avdeling for farmakologi, Institutt for klinisk medisin, Det Medisinske Fakultet, Universitetet i Oslo – 2. opponent

Professor Inigo Zubiavrre Martinez, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder:

Førsteamanuensis Veronika Pettersen, Institutt for medisinsk biologi, UiT Norges arktiske universitet