Disputas – Master of Science Merete Storflor

Avhandlingen er tilgjengelig her! The doctoral thesis! Prøveforelesning over oppgitt emne holdes  kl. 12.15, samme sted: "Preserving antibiotics: Understanding antimicrobial resistance" . Prøveforelesningen vil også bli strømmet/the trial lecture will also be streamed. Disputas starter kl. 1415 Auditoriet er åpent for publikum, men disputasen vil likevel bli strømmet her. Opptak av disputasen vil være tilgjengelig i et døgn. The auditorium is open to the public, but the defense will also be streamed here. A recording of the defense will be available for 24 hours.

Populærvitenskapelig sammendrag av avhandlingen:

Bacterial infections contribute significantly to global mortality, with their impact worsened by ineffective preventive measures and the misuse of antibiotics. Overusing antibiotics creates a situation where bacteria face constant pressure, inadvertently promoting the development of antibiotic resistance. One key method bacterium employ for the spread of resistance is natural transformation, a process involving the transfer of genetic material horizontally among bacterial populations. This mechanism allows bacteria to acquire genetic material from their surroundings, relying on a state called competence.

Competence is induced by external cues like population density and nutrient availability. In Gram-negative bacteria, inner membrane proteins register these signals, translating them into a specific response. The biological membranes of bacteria play a crucial role in signal processing and act as barriers to antibiotics and external DNA. This thesis delves into understanding how bacteria respond to stressors, such as extracellular DNA and antibiotics, and investigates the activity and localization of proteins within the inner membrane.

Hovedveileder

Forsker Sören Abel, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

Biveileder

Forsker Klaus Harms, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Ph.d. Jacob Malone, University of East Anglia, UK.
 

Bedømmelseskomité

Førsteamanuensis Gabriela Jorge da Silva, Faculty of Pharmacy and Center for Neuroscience and Cell Biology, University of Coimbra – 1. Opponent.
Førsteamanuensis Tobias Dörr, Weill Institute for Cell & Molecular Biology, Cornell University - 2. opponent.
Professor Natasa Skalko-Basnet, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.
 

Disputasleder: Førsteamanuensis Kjell H. Halvorsen, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.