Sergei Valkov

Avhandlingen er tilgjengelig her/The doctoral thesis 

Prøveforelesning over oppgitt emne holdes kl. 09.15:

«Discuss differences in methods, results and conclusions in experimental animal studies vs clinical trials in therapeutic hypothermia after cardiac arrest»

Auditoriet er åpent for publikum, men vil også bli strømmet her/ The auditorium is open to the public, but will also be streamed here:
Direktelenke prøveforelesning: 

Disputasen starter 11.15
Direktelenke Disputas: 

_{Opptak av disputasen vil være tilgjengelig i et døgn. / A recording of the disputation will be available for 24 hours.}

Populærvitenskapelig sammendrag av avhandlingen:

Medical professionals worldwide report cases describing successful resuscitation and rewarming of accidental hypothermia victims with cardiac arrest without or with minimal neurological sequelae. It was possible even when body temperature was as low as 13,7 °C and cardiac arrest lasted almost 7 hours. To find out and evaluate some possible mechanisms for that, we have cooled pigs down to 27°C. We first assessed the effects of 3-hours hypothermia and subsequent rewarming with a beating heart. We discovered that the blood flow and oxygen delivery was restored after rewarming in essential organs - brain and heart- despite cardiac dysfunction due to hypothermia. After that, we studied the effects of CPR for 3 hours at the same temperature without rewarming, employing an automated CPR device. We found that blood flow generated by CPR could sustain sufficient oxygen delivery to maintain aerobic metabolism, and cerebral autoregulation was functioning, providing unaltered brain blood flow during the first 2 of 3 hours of CPR.

Hovedveileder

Professor Torkjel Tveita, Institutt for klinisk medisin, UiT Norges arktiske universitet

Bedømmelseskomité

Professor Sten Rubertsson, Uppsala University / Uppsala University Hospital - 1. opponent.

Professor Kjetil Sunde, Institutt for klinisk medisin, Universitetet i Oslo - 2. opponent.

Førsteamanuensis Åse Florholmen-Kjær, Institutt for klinisk medisin, UiT Norges arktiske universitet  – leder av komité.

Disputasleder:

Førsteamanuensis II Shirin Kordasti Frisvold, Institutt for klinisk medisin, UiT Norges arktiske universitet

De som ønsker å opponere ex auditorio kan sende e-post til leder av disputasen /Opponents’ ex auditorio should sign up to leader of defense by e-mail to: shirin.frisvold@uit.no