Giovanni Allaoui

Avhandlingen er tilgjengelig her! / The doctoral thesis is available here!

Auditoriet er åpent for publikum og  trømmes og et opptak vil være tilgjengelig i et døgn.
The auditorium is open to the public. The defense will still be streamed, and a recording of the disputation will be available for 24 hours.

Prøveforelesning over oppgitt emne starter kl. 09.15 / The trial lecture starts at 09.15
Tittel/Title:  «The why, when and how to use a laboratory test for prediction of diabetes or cardiovascular disease?»
Prøveforelesningen strømmes her / The trial lecture will be streamed here

Disputasen starter kl. 11.15 / The defense starts at 11.15
Disputasen strømmes her / The defense will be streamed here

De som ønsker å opponere ex auditorio kan sende en e-post til leder av disputasen innen kl. 12:00 disputasdagen: bsm000@post.uit.no
If you want to oppose ex. auditorio, send an e-mail to the leader of the defence before 12:00 on the day of the defence: bsm000@post.uit.no

Populærvitenskapelig sammendrag av avhandlingen/ Summary of the thesis

It is estimated that 10.5% of the world’s population are living with type 2 diabetes, and the number of individuals diagnosed with the disease is increasing. Type 2 diabetes slowly develops over many years and is characterised by a decrease in the effect and production of insulin, which is a hormone that regulates blood sugar levels. This process results in chronically increased blood sugar levels and eventually type 2 diabetes diagnosis. The disease is irreversible and may lead to several complications such as nerve damage, blindness, foot ulcers and amputation, heart disease, kidney disease, and early death. Therefore, it is important to prevent type 2 diabetes from developing as early as possible.

This thesis aimed to investigate the associations of several blood biomarkers related to lipid, glucose, and hormone homeostasis with type 2 diabetes, as well as how they change over time. We compared these blood biomarkers in healthy controls with individuals who developed type 2 diabetes and followed what has happened 15 years before diagnosis as well as what happened 15 years after, with three to five repeated measurements.

The results revealed that the individuals who developed type 2 diabetes had different and more adverse levels of several of the biomarkers compared to healthy controls for up to 15 years before diagnosis. These results shows that blood biomarkers can successfully be used to evaluate if individuals are at risk of developing diabetes type 2 in the future.

 

Veiledere/ Supervisors:
Hovedveileder/Main supervisor:
Førsteamanuensis Vivian Hætta Berg, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Biveiledere/supervisors:

Førsteamanuensis Ole Martin Fuskevåg, Institutt for klinisk medisin, UiT Norges arktiske universet.
Førsteamanuensis Maria Averina, Institutt for klinisk medisin, Det helsevitenskapelige fakultetUiT Norges arktiske universitet.
Professor Karin Charlotta Maria Rylander, Institutt for samfunnsmedisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

Bedømmelseskomité/Defensecomitee:
Professor Kåre Inge Birkeland, Universitetet i Oslo – 1. opponent.
Professor Kristin Moberge Aakre, Universitetet i Bergen – 2. opponent.
Førsteamanuensis Hege Lynum Pedersen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder/ Leader of defense:
Professor Emeritus Bård Smedsrød, Insitutt for medisinsk biologi, , Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.