Sofia Maria Öling

The doctoral thesis!  Avhandlingen er tilgjengelig her!  Prøveforelesning over oppgitt emne holdes kl. 0915, samme sted: "In vivo and ex vivo models for the investigation of gene function in endothelial cells in different tissue contexts". Prøveforelesningen vil også bli strømmet/the trial lecture will also be streamed. Disputasen starter kl 1115. Auditoriet er åpent for publikum, men disputasen vil også bli strømmet her. The auditorium is open to the public, but the defense will also be streamed here. A recording of the defense will be available for 24 hours.

Populærvitenskapelig sammendrag av avhandlingen:

The study of cell type-specific genes and how they are modified under various conditions is important for our understanding of the human body. This can be done by analyzing individual cells, but the techniques used can introduce artifacts, so we analyzed tissue samples containing cells in their natural state. We identified cell type-enriched genes in stomach and colon tissue and identified a small set of genes with a higher expression in men. By expanding our analysis to multiple organs, we identified genes expressed in same cell types across different tissues, including endothelial cells (EC), which line all blood vessels. We studied the function of the EC gene KANK3 and found that it has a role in cell movement and blood clotting. We show the value of using alternative methods to analyze existing data, and how such data can be used to select genes for functional studies.

Hovedveileder
Førsteamanuensis Lynn Butler , Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

Biveileder
Postdoc. Philip James Dusard, KTH Royal Institute of Technology, Stockholm, Sweden. 

Bedømmelseskomité
Professor Jon Frampton, University of Birmingham – 1. Opponent.
Dr. Myriam Chimen, Nestlé Research, Sveits - 2. opponent.
Førsteamanuensis Synnøve Magnussen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité. 

Disputasleder: Professor Ruth Paulssen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.