Adrina Kalasho Kuzmiszyn

Avhandlingen er tilgjengelig her!  The doctoral thesis!   Prøveforelesning over oppgitt emne holdes kl. 10.15: «Cardiovascular health in the face of global warming ». Auditoriet er åpent for publikum, men vil også bli strømmet her. The auditorium is open to the public. The defense will still be streamed here.   Disputasen starter 12.15 Disputasen vil bli strømmet her. The defense will be streamed here. Opptak av disputasen vil være tilgjengelig i et døgn. / A recording of the disputation will be available for 24 hours.  De som ønsker å opponere ex auditorio kan sende e-post til leder av disputasen.  Opponents’ ex auditorio should sign up to leader of defense by e-mail to: jan.o.winberg@uit.no

Populærvitenskapelig sammendrag av avhandlingen: 

Hypothermia-induced cardiac dysfunction is one of the feared complications commonly seen when rewarming accidental hypothermic patients. Currently, there are no evidence-based pharmacological treatments for treating patients with cardiovascular instability and core temperature < 30°C. We have therefore investigated five cardio- and vasoactive drugs in vitro, down to 20°C.

Our research shows that all drugs are functionally active at low temperatures while their target proteins are considerably affected by hypothermia alone. This indicates a risk for complications when administering conventional doses of potent cardiovascular medications in cold patients, prompting further research for potential pharmacological treatment algorithms in accidental hypothermia in the future.

Hovedveileder
Førsteamanuensis Erik Sveberg Dietrich, Institutt for medisinsk biologi, UiT – Norges arktiske universitet / Universitetet i Oslo.

Biveiledere
Professor Torkjel Tveita, Institutt for klinisk medisin, UiT- Norges arktiske universitet.

Bedømmelseskomité
Ph.d. Giacomo Strapazzon, Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, Italia - 1. opponent.
Professor Silje Skrede, Universitetet i Bergen - 2. opponent.
Professor Ellen Aasum, Institutt for medisinsk biologi, UiT – Norges arktiske universitet – leder av komité. 

Disputasleder: Professor emeritus Jan-Olof Winberg, Institutt for medisinsk biologi, UiT- Norges arktiske universitet.