Eike Christopher Struck

Avhandlingen er tilgjengelig her!  The doctoral thesis! Prøveforelesning over oppgitt emne holdes kl. 09.15, samme sted: “Methods used to discriminate cell specific signatures in bulk sequencing approaches.”  Prøveforelesningen vil også bli strømmet/the trail lecture will also be streamed. Disputasen starter kl. 1115 Disputasen vil bli strømmet her. The defense will be streamed here. Opptak av disputasen vil være tilgjengelig i et døgn. A recording of the disputation will be available for 24 hours.

Populærvitenskapelig sammendrag av avhandlingen:

This research focusses on vascular endothelial cells, which form the innermost layer of our blood and lymphatic vessels. These cells respond to various signals and play crucial roles in many functions, including inflammation. Genes that are expressed only in this cell type tend to be important in such roles. Here, we analyze changes in the gene expression of endothelial cells in response to an inflammatory trigger, we identify endothelial (and other) cell type specific genes in adipose tissue and investigate the role of a novel endothelial specific gene (KANK3) in cell function. We found that changes in gene expression induced during inflammation occur in two main phases and identified differences between male and females’ cells. We showed that KANK3 has a role in how cells behave when they are exposed to forces (similar to those they experience from blood flow), in cell movement and the regulation of blood clotting.

Hovedveileder
Førsteamanuensis Lynn Butler, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet. 

Biveiledere
Researcher Philip Dusart, Science for Life Laboratory, Department of Protein Science, Royal Institute of Technology (KTH), Stockholm, Sweden.
Forsker Clement Naudin, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet. 

Bedømmelseskomité
Førsteamanuensis Ljubica Matic, Karolinska Institutet - 1. opponent.
Professor Patricia Lalor, University of Birmingham – 2. opponent.
Professor Inigo Martinez, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet - leder av komité.

Disputasleder: Førsteamanuensis Madhu Wagle, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.