Fatema Amatur Rahman

Avhandlingen er tilgjengelig her! / The doctoral thesis is available here!

Auditoriet er åpent for publikum. Disputasen vil strømmes og et opptak vil være tilgjengelig i et døgn.

The auditorium is open to the public. The defense will still be streamed, and a recording of the disputation will be available for 24 hours.

Prøveforelesning over oppgitt emne starter kl. 10.15 / The trial lecture starts at 10.15
Tittel/Title: «Stories of success and failure of protease inhibitors in treatment of diseases.»
Prøveforelesningen strømmes her / The trial lecture will be streamed here

Disputasen starter kl. 12.15 / The defense starts at 12.15
Disputasen strømmes her / The defense will be streamed here

De som ønsker å opponere ex auditorio kan sende e-post til leder av disputasen. 
Opponents’ ex auditorio should sign up to leader of defense by e-mail to: hallvard.olsvik@uit.no

Populærvitenskapelig sammendrag av avhandlingen/ Summary of the thesis

The spread of antibiotic multi-resistance among human pathogenic bacteria is a major global health concern, and development of new treatment strategy are urgently needed.
The enzymes thermolysin, pseudolysin and aureolysin are all bacterial virulence factors. The bacteria use theses virulence factors to invade the host and generate nutrition for bacterial growth. Molecules inhibiting the virulence enzymes are suggested to be promising alternative treatment strategies. The molecular structure of these virulence factors have huge similarities with important enzymes in the human body. Obtaining molecules that inhibit the bacterial but not the human enzymes is therefore challenging.
Structural information about the inhibition of both the bacterial virulence factors and their human counterparts is therefore important. In the present thesis we have identified inhibitors of the three bacterial virulence factors using enzyme inhibition kinetics and molecular modelling. In addition, we have tested their inhibition of human enzymes with large structural resemblance with the three bacterial virulence factors.

Veiledere/ Supervisors:
Hovedveileder/Main supervisor:
Professor Ingbrigt Sylte, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Biveiledere/supervisors:
Professor Jan Olof Winberg, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Bedømmelseskomité/Defensecomitee:
Dr. Jennifer Vandooren, Department of Microbiology, Immunology and Transplantation, Rega Institute of Medical Research, KU Leuven, (Belgia) – 1. opponent.
Professor Rigmor Solberg, Department of pharmacy, the faculty of Mathematics and Natural Sciences, University of Oslo  – 2. opponent.
Professor Ole Kristian Greiner-Tollersrud, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder/ Leader of defense:
Førsteamanuensis Hallvard Lauritz Olsvik, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.