Marthe Norreen-Thorsen

Avhandlingen er tilgjengelig her

The doctoral thesis

Prøveforelesning over oppgitt emne holdes kl. 9.15

«Evolution of endothelia, and endothelial heterogeneity across tissues and vascular beds”

Prøveforelesning strømmes her

The trial lecture will be streamed here

Direktelenke Disputas

Opptak av disputasen vil være tilgjengelig i et døgn.

The defense will still be streamed here

A recording of the disputation will be available for 24 hours.

Populærvitenskapelig sammendrag av avhandlingen:

Our body is made up of different cell types with unique genes that instruct them on making proteins - the expression profile of which determine cell type characteristics and functions. Analysing gene expression in individual cells can be challenging, especially for delicate or hard-to-separate cell types. In this study, we examined human tissue data without separating the cells. By comparing gene expression patterns, we firstly identified genes specific to different cell types in fat. We then expanded this analysis to 15 tissues, and we found similarities between related cell types across tissues, including endothelial cells (EC) lining blood vessels. Focusing on one gene expressed specifically in EC, ADGRL4, we uncovered its potential roll in the regulation of cell structure, inflammation-related proteins, blood clotting, and immune responses.

Hovedveileder

Førsteamanuensis Lynn Butler, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Biveiledere

ResearcherPhilip Dusart, Science for Life Laboratory, Department of Protein Science, Royal Institute of Technology (KTH), Stockholm, Sweden

Bedømmelseskomité

Professor Ola Spjuth, Uppsala Universitet - 1. opponent.

Professor Karen Kristine Sørensen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet- 2. opponent.

Professor Ole Greiner Tollersrud, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder: Professor Yngve  Figenschau, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet