Susannah von Hofsten

Avhandlingen er tilgjengelig her! The doctoral thesis! Prøveforelesning over oppgitt emne holdes kl. 10.15, i Auditorium Cerebrum: “The effect of DAMPs and ICD in cancer immunity: differences between causation and correlation”. Prøveforelesningen vil også bli strømmet/the trail lecture will also be streamed. Disputasen starter kl. 1215 i Auditorium Cerebrum. Disputasen vil bli strømmet her.  Opptak av disputasen vil være tilgjengelig i et døgn. The defense will be streamed here.  A recording of the disputation will be available for 24 hours.

Populærvitenskapelig sammendrag av avhandlingen:

Cancer is one of the leading causes of death worldwide. The current project focused on exploring the potential of a new type of compounds, called marine product mimics (MPMs), to become new drugs for cancer treatment. The MPMs were designed with inspiration from antimicrobial molecules and natural compounds that have been isolated from marine animals. It was shown that the compound MPM-1 could kill several different types of cancer cells. Nine additional MPMs were made and included in more studies. Results indicated that the MPMs penetrate cancer cells and cause cell death from within. They also caused the cancer cells to release molecules with immune stimulating effects. This suggests that the MPMs can stimulate the immune system to fight cancer. A mouse study was performed where tumors were treated with injections with MPM-1. This caused the tumors to disappear completely. However, whether the MPMs have the potential to be used in treatment of human cancer remains to be seen.

Hovedveileder
Førsteamanuensis Gerd Berge, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

Biveileder
Professor Morten Bøhmer Strøm, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Førsteamanuensis Synnøve Magnussen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Førsteamanuensis II Dominik Albert Ausbacher, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet. 

Bedømmelseskomité
Førsteamanuensis Abhishek Garg, KU Leuven ​– 1. opponent.
Ph.d. Inger Øynebråten, Oslo Universitetssykehus - 2. opponent.
Professor Inigo Martinez, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder: Professor Kristin A Fenton, Institutt for medisinsk biologi,Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.