Hemmingsen disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:
“Advanced topical delivery systems for membrane-active antimicrobials. Exploring nature to improve antimicrobial wound therapy”
Avhandlingen er tilgjengelig her! / The doctoral thesis is available here!
Auditoriet er åpent for publikum, men vil også bli strømmet her/ The auditorium is open to the public. The defense will still be streamed.
Opptak av disputasen vil være tilgjengelig i et døgn. / A recording of the disputation will be available for 24 hours.
Prøveforelesning over oppgitt emne starter kl. 09.15 / The trial lecture starts at 09.15
Tittel/Title: “Reconstituted human skin models for evaluating topically applied anti-infectives”
Prøveforelesningen strømmes her / The trial lecture will be streamed here
Disputasen starter kl. 11.15 / The defense starts at 11.15
Disputasen strømmes her / The defense will be streamed here
De som ønsker å opponere ex auditorio kan sende e-post til leder av disputasen.
Opponents ex auditorio should sign up to leader of defense by e-mail to:
paal.johnsen@uit.no
Populærvitenskapelig sammendrag av avhandlingen/ Summary of the thesis
Today about 2% of the general population will encounter challenges to treat chronic wounds, and the numbers are expected to rise due to an aging population with an increased disease burden and resistant bacteria increasing the threat of chronic wounds. Many new antimicrobial compounds are found in laboratories every year and still, we struggle to bring new medicines to patients. Smart solutions are needed to solve the problem.
We wanted to take advantage of nature’s toolbox to improve the effect of new antimicrobial compounds using pharmaceutical technology, thus improve bacterial killing and healing of wounds. To achieve our goals, we designed a system called liposomes-in-hydrogel comprising soy liposomes and chitosan hydrogel from shrimps to improve the effects of compounds mimicking nature own’s defence molecules, antimicrobial peptides.
Using this nature-inspired combination, we lowered inflammation and improved killing of bacteria commonly found in wounds, improving the healing.
Veiledere/ Supervisors:
Hovedveileder/Main supervisor:
Professor Natasa Skalko-Basnet, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Biveileder/supervisor:
Professor Gøril Eide Flaten, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Bedømmelseskomité/Defensecomitee:
Professor Claus-Michael Lehr, Saarland University, Germany – 1. opponent
Associate professor Giuseppina Sandri, University of Pavia, Italy – 2. opponent
Førstelektor Siri Forsdahl, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité
Disputasleder/ Leader of defense:
Professor Pål Jarle Johnsen, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet