Madhu Wagle Parajuli

Avhandlingen er tilgjengelig her!

Auditoriet er åpent for publikum under både prøveforelesning og disputas, men vil også bli strømmet.

Prøveforelesning starter kl. 09.15:

Prøveforelesnings tittel «Oral health and adverse pregnancy outcomes.»

Prøveforelesning vil be strømmet/ the trial lecture will be streamed!

Disputas starter kl 11.15
Disputasen vil strømmet/ the defence will be streamed!

Opptak av disputasen vil være tilgjengelig i et døgn./ A recording of the disputation will be available for 24 hours.

Populærvitenskapelig sammendrag av avhandlingen:

Oral health among pregnant women

The physiological changes that occur during the pregnancy are known to affect women´s oral health. Pregnant women are more vulnerable to oral diseases when compared to non-pregnant. Better understanding of the relation between changing oral microbial milieu and risk of pregnancy complications and associated mechanisms could help to improve maternal and perinatal outcomes. We investigated the pregnancy associated changes in oral bacterial milieu with a focus on cariogenic bacterial load, oxidative stress and nitric oxide levels in the saliva, and their effect on pregnancy outcome. We found an increase in salivary oxidative level and decrease in antioxidant capacity along with an increase in colonization by caries responsible bacteria Streptococcus mutans in pregnant women. The salivary nitric oxide levels were also higher among the pregnant women with increase in its level as pregnancy advanced. There was no association between dental caries and risk of preterm birth.

Hovedveileder

Professor II Ganesh Acharya, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Biveileder

Professor II Purusotam Basnet, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Bedømmelseskomité

Professor Nagihan Bostanci, Karolinska Institutet - 1. opponent.

Professor Lars Henning Pedersen, Institutt for klinisk medisin og biomedisin, Aarhus Universitet / Aarhus Universtetshospital - 2. opponent.

Førsteamanuensis og overlege Khaled Meknas, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder: Førsteamanuensis og overlege Rasmus Goll, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Parajuli disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen: “Oral health in pregnancy: changes in oral bacterial milieu related to cariogenic bacterial load, oxidative stress and nitric oxide levels in the saliva and their effect on pregnancy outcome”

Parajuli disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:

“Oral health in pregnancy: changes in oral bacterial milieu related to cariogenic bacterial load, oxidative stress and nitric oxide levels in the saliva and their effect on pregnancy outcome”