Karolina Szafranska

Avhandlingen er tilgjengelig her! / The doctoral thesis is available here!


Auditoriet er åpent for publikum, men disputasen vil i tillegg bli strømmet. Opptaket av disputasen vil være tilgjengelig i et døgn.
The auditorium is open to the public. The defense will also be streamed. A recording of the disputation will be available for 24 hours.

Prøveforelesning over oppgitt emne starter kl. 10.15 / The trial lecture starts at 10.15
Tittel/Title:  “The elephant in the room: Role of LSEC on the clearance of nanomedicines and adenoviral vectors” .
Prøveforelesningen strømmes her / The trial lecture will be streamed here

Disputasen starter kl. 12.15 / The defense starts at 12.15
Disputasen strømmes her / The defense will be streamed here

De som ønsker å opponere ex. auditorio kan sende e-post til leder av disputas: Trond Lamark trond.lamark@uit.no innen kl. 13.00 disputasdagen.


Populærvitenskapelig sammendrag av avhandlingen/ Summary of the thesis

This thesis focuses on liver sinusoidal endothelial cells (LSEC) and their characteristic features called fenestrations. LSEC create a barrier between the bloodstream and the interior of the liver and allow the filtration of unwanted particles. This filtration is possible due to nanometre diameter holes – fenestrations - in LSEC that act as a sieve.

This study contains 4 parts: a review of the known drugs and agents influencing fenestrations, a study focused on LSEC imaging using different types of microscopes, an article describing different image analysis techniques that allow to efficiently count and measure fenestrations and lastly the application of all these optimized methods to study xanthines – substances that can be found in food or beverages – and their effects on LSEC. The most known examples of xanthines are caffeine present in coffee and theobromine in chocolate.

Veiledere/ Supervisors
Hovedveileder/Main supervisor:
Professor Peter McCourt, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Biveiledere/supervisors:
Professor Karen Kristine Sørensen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Postdoktor Bartlomiej Zapotoczny, UiT Norges arktiske universitet.

Bedømmelseskomité/Defensecomitee

Førsteamanuensis Caroline Adiels, University of Gothenburg – 1. opponent.
Reader Patricia Lalor, University of Birmingham – 2. opponent.
Professor Inigo Martinez, UiT Norges arktiske universitet – leder av komité.

Disputasleder/ Leader of defense
Førsteamanuensis Professor Trond Lamark, UiT Norges arktiske universitet.