Cauzzo will defend her thesis for the PhD degree in Health Sciences:
“Microscopy Meets Nanomedicine: The Challenge of Liposomes. Selecting, Understanding, and Adapting Imaging Techniques to Localize and Characterize Nanocarriers”
The trial lecture will start at 10:00 AM.
The theme for the trial lecture will be: "Current and future roles of lipid nanoparticles for mRNA vaccination"
The defence will start at 12:15 AM.
A recording of the disputation will be available for 24 hours.
Abstract of thesis:
Nanocarriers are small, mostly spherical structure of around 100-200 nm, which changed clinical therapy with the so-called nanomedicine. We all witnessed a huge impact the lipid-based nanocarriers had in delivery of Covid-vaccines, confirming not only that nanomedicine is here to stay, but also that success is reachable. However, to avoid disappointment in animal and human studies, we dived into deeper characterization of the most relevant nanocarriers, liposomes, to understand and predict the in vivo challenges. Following the concept that seeing is believing, we focused on using advanced microscopy as a tool to characterize and understand nanocarriers, their interactions with biological environment, and their accumulation inside the cells. Fluorescence imaging was the horsepower of this work, to which we added some options that do not require bright molecules to begin with. Nanomedicine is the present and future of medicine. We propose advance microscopy as tool to achieve it faster.
Professor Nataša Škalko-Basnet, Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway
Associate Professor Ann Mari Holsæter, Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway
Dr. Aurélie Vigne, Elvesys, France
Professor Jessica Rosenholm, Åbo Akademi University, Finland – 1st opponent.
Professor Ulrich Massing, Andreas Hettich GmbH &Co KG, University of Freiburg, Germany- 2nd opponent.
Associate Professor Elizabeth Aarag Fredheim, Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway – Third member and chair of the evaluation committee.
Chair of the Defense: Professor Guro Forsdahl, Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway