Anthimi Palara

Avhandlingen er tilgjengelig her! / The doctoral thesis is available here!

Auditoriet er åpent for publikum, men disputasen vil også bli strømmet. Opptaket av disputasen vil være tilgjengelig i et døgn.
The auditorium is open to the public. The defense will still be streamed. A recording of the disputation will be available for 24 hours.


Prøveforelesning over oppgitt emne starter kl. 10.15 / The trial lecture starts at 10.15
Tittel/Title: "Selective autophagy in innate and adaptive immune responses".
Prøveforelesningen strømmes her / The trial lecture will be streamed here

Disputasen starter kl. 12.15 / The defense starts at 12.15
Disputasen strømmes her / The defense will be streamed here

 
Populærvitenskapelig sammendrag av avhandlingen/ Summary of the thesis

Autophagy is a cellular renovation process where our cells clean house to get rid of damaged or surplus components. Autophagy declines as we get old and when autophagy does not work properly, we risk developing diseases associated with ageing like Parkinson’s or Alzheimer’s disease and ALS. The delivery of cellular waste, which we call cargo, is mediated by proteins called autophagy receptors.

Our research group discovered the first autophagy receptor called p62. p62 exists in cells either as free floating filaments or as round, dense p62 bodies. p62 bodies act as a platform where p62 recruits selected cargos. p62 also orchestrates the construction of a membrane engulfing both p62 and the cargo.

In this study we used both human and mice cells that expressed different modified forms of p62 to study regulation and formation of p62 bodies. Microscopy and various biochemical methods were used to explore the role of three functional elements in p62 that determines the ability of p62 to form bodies and to get the waste degraded by autophagy.

Veiledere/ Supervisors:
Hovedveileder/Main supervisor:
Professor Terje Johansen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Biveiledere/supervisors:
Førsteamanuensis Trond Lamark, Institutt for medisinsk biologi, Det helsevitenskapelige fakulteti, UiT Norges arktiske universitet.
Overingeniør Hallvard Lauritz Olsvik, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Bedømmelseskomité/Defensecomitee:
Professor Björn Stork, University Hospital Düsseldorf – 1. opponent.
Ph.d. Alf Håkon Lohsen Lystad, Universitetet i Oslo – 2. opponent.
Førsteamanuensis Maria Perander, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder/ Leader of defense:
Forsker Synnøve Magnussen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.