Kirsten Maria Jansen

Avhandlingen er tilgjengelig her!

The doctoral thesis!

Prøveforelesning starter kl 10.15 og har følgende tittel: 

“Physiological and biochemical characteristics of metabolically healthy obesity”

Prøveforelesningen vil også bli strømmet/the trial lecture will also be streamed!

Disputas starter kl 12.15

Disputasen vil bli strømmet her! 

The defense will be streamed here!

Opptak av disputasen vil være tilgjengelig i 24 timer. 

A recording of the disputation will be available for 24 hours. 

De som ønsker å opponere ex auditorio kan sende e-post til leder av disputasen.
Opponents ex auditorio should sign up to leader of defense by e-mail to Professor Karen Sørensen 

Populærvitenskapelig sammendrag:

Obesity causes alterations in the energy metabolism of the heart which can lead to heart failure. Using diet-induced obese mice, we show that dietary supplementation with Calanus oil was able to prevent such obesity-related shifts in myocardial metabolism and to protect the heart towards experimentally induced myocardial infarction. Using a cardiomyocyte cell line, we also found that small amounts of hydrolyzed wax ester from Calanus oil, containing a unique composition of (mono- and poly-unsaturated) fatty acids and fatty alcohols, almost completely rescued the cells from nutritional stress induced by the saturated fatty acid, palmitate. Further analyses suggest that this protective effect was due to alleviation of so-called endoplasmatic reticulum (ER) stress. Finally, we showed that Calanus oil antagonized some of the obesity-induced alterations in the gut microbiota. Collectively, these data suggest that Calanus oil can be an alternative to anti-obesity/anti-diabetic drugs.

Hovedveileder

Professor Terje Steinar Larsen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Professor Ellen Aasum, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Bedømmelseskomité

Research Professor (M.D., D.Sc.) Jan Kopecký, Institute of Physiology of the Czech Academy of Sciences, Charles University, Prague - 1. Opponent

Forsker / Researcher Oddrun Anita Gudbrandsen, Department of Clinical Medicine, Faculty of Medicine, University of Bergen - 2. Opponent

Førsteamanuensis Mari Gabrielsen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité

Disputasleder: Professor Karen Kristine Sørensen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet