Juncal Garcia Garcia

Avhandlingen er tilgjengelig her! / The doctoral thesis is available here!

Disputasen og prøveforelesningen blir strømmet. The defense and the trial lecture will be streamed.

Prøveforelesning over oppgitt emne starter kl. 10.15 / The trial lecture starts at 10.15
Tittel/Title: "The role of PTMs in autophagy regulation"
Prøveforelesningen strømmes her / The trial lecture will be streamed here

Disputasen starter kl. 12.15 / The defense starts at 12.15
Disputasen strømmes her / The defense will be streamed here

De som ønsker å opponere ex auditorio kan sende e-post til leder av disputasen. 
Opponents ex auditorio should sign up to leader of defense by e-mail to:
maria.perander@uit.no

 
Populærvitenskapelig sammendrag av avhandlingen/ Summary of the thesis

Planet earth can be a hostile place, where organisms of all sorts are in a constant fight for survival. Evolution has provided cells the ability to improve the quality of those survival mechanisms, arriving to very high complex networks that work coordinately to try to ensure the continuity of the species.

At a cellular level, eukaryote cells have developed a high degree of complexity in order to maintain their homeostasis. One of the mechanisms that the cells has to thrive is autophagy, which in Greek means “self-eating”. Cells are able to degrade their own components (eat themselves) in order to obtain energy in times of scarcity.

In this study, we have investigated the role of two proteins called TRIM27 and TRIM32 in this cellular mechanism.

Our findings suggest that both proteins are involved in autophagy and that they may mediate the regulation of this process, and thereby contribute to the healthiness of the cell.

 
Veiledere/ Supervisors:
Hovedveileder/Main supervisor:
Professor Eva Sjøttem, Institutt for medisinsk biologi,Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Biveiledere/supervisors:
Førsteamanuensis Trond Lamark, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Professor Terje Johansen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Bedømmelseskomité/Defensecomitee:
Professor Jörn Dengjel, Department of Biology, Faculty of Science and Medicine, University of Fribourg, Switzerland – 1. opponent
Project group leader Maria Lyngaas Torgersen, Centre for Cancer Cell reprogramming, Faculty of Medicine, Oslo University Hospital, Norway - 2. opponent
Forsker Hege Lynum Pedersen, Institutt for biologisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité

Disputasleder/ Leader of defense:
Maria Perander, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet