Elin Storjord

Avhandlingen er tilgjengelig her! / The doctoral thesis is available here!

På grunn av koronautbruddet vil disputasen bli strømmet . Opptak av disputasen vil være tilgjengelig i en måned.
The defense will be streamed because of the corona outbreak. A recording of the disputation will be available for one month.

Prøveforelesning over oppgitt emne starter kl. 10.15/ The trail lecture starts at 10.15
Tittel/Title: “Genetics with focus on genotype-phenotype correlations, of the acute hepatic porphyrias”
Prøveforelesningen strømmes her / The trail lecture will be streamed here

Disputasen starter kl. 12.15 / The defense starts at 12.15
Disputasen strømmes her / The defense will be streamed here

De som ønsker å opponere ex auditorio kan sende e-post til leder av disputasen. 
Opponents ex auditorio should sign up to leader of defense by e-mail to:
anders.w.hovland@uit.no

Populærvitenskapelig sammendrag av avhandlingen/ Summary of the thesis:
Acute intermittent porphyria (AIP) is a metabolic disease that can result in attacks with acute abdominal pain, paresis, fatigue and increased risk of kidney failure and liver cancer.
In a case control study of 50 AIP cases and 50 matched controls we interviewed the participants, drew blood samples and obtained diet logbooks.
Fasting, infections, medications and stress can trigger an AIP attack, and we found stress as the most common trigger. Plasma cytokines were elevated in the AIP cases compared to the matched controls as a sign of low-grade inflammation. We investigated how to handle blood samples to get the most correct level of cytokines, concluding that analysis of cytokines can be performed in EDTA plasma samples stored at 4ºC for up to 4 hours before centrifugation. 
A low carbohydrate intake may trigger AIP attacks. We found that persons with AIP had a lower carbohydrate intake than recommended, and that a lower insulin level was associated with higher AIP disease activity.

Veiledere/ Supervisors:
Hovedveileder/Main supervisor:
Professor Ole Lars Brekke, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Biveiledere/supervisors:
Professor Erik Waage-Nielsen, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Professor Tom Eirik Mollnes, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Bedømmelseskomité/Defensecomitee:
Associate professor Staffan Wahlin, Karolinska Institutet, Sverige – 1. opponent
Professor Wenche Sjursen, NTNU, Norge – 2.opponent
Førsteamanuensis Khalid Al-Shibli, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité

Disputasleder/ Leader of defense:
Førsteamanuensis Anders Hovland, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet