Disputas Cand.med. Maria Arlén Larsen
Cand.med Maria Arlén Larsen disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:
“Early markers of metabolic disease in obesity
- A study of postprandial triglycerides, leptin and adiponectin interactions in the view of normal and dysregulated metabolism”
Kort populærvitenskapelig sammendrag av avhandlingen:
Biomarkers of disease in obese individuals-Potential to treat at an earlier stage and prevent disease
In this thesis 50 obese individuals with and without lifestyle diseases was included, in addition to 17 normal weight and healthy individuals. The aim was to find sensitive, early biomarkers on metabolic dysregulation in obese individuals, and to examine fat metabolism and fat hormone regulation after a meal.
This thesis found metabolically healthy (without manifestation of lifestyle disease) obese individuals to have delayed fat metabolism, and resistance for the hormones insulin and leptin. Furthermore, all of the obese individuals had an unbalance in the regulation of the hormones leptin and adiponectin after a meal. Fasting triglycerides in the upper normal level, and a measure of insulin resistance, HOMA-IR, was found to be sensitive biomarkers for early detection of metabolic dysregulation in obese individuals. The leptin: adiponectin ratio was found to be a suitable biomarker.
This thesis adds novel and valuable knowledge in the field of energy metabolism in obese individuals, and suggests new biomarkers to detect lifestyle diseases early, to prevent disease and treat at an earlier stage.
Hovedveileder professor Jon R. Florholmen
Biveileder førsteamanuensis Rasmus Goll
Professor emeritus Stephan Rössner, Karolinska institutet, Sverige – 1. opponent
Professor Gunnar Mellgren, Klinisk institutt universitetet i Bergen, – 2. opponent
Førsteamanuensis Guri Grimnes, UiT Norges arktiske universitet – leder av komité
Førsteamanuensis Marijke Van Ghelue, UiT Norges arktiske universitet
Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted: “Personalized obesity treatment - challenges and opportunities”