Cand.med Ludvig Balteskard Rinde disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:
“Arterial cardiovascular diseases and risk of venous thromboembolism”
Kort sammendrag av avhandlingen:
Despite differences in epidemiology, pathology, and treatment, growing evidence suggests a bidirectional relationship between venous thromboembolism (VTE), a collective term for pulmonary embolism (PE) and deep vein thrombosis (DVT), and arterial cardiovascular diseases (CVD i.e., myocardial infarction [MI] and ischemic stroke). The aim of this thesis was to investigate the impact of atherosclerosis, MI, ischemic stroke on the risk of VTE.
In all four papers, we used participants from the fourth, fifth and six survey of the Tromsø Study. In paper I, the participants consisted of a subgroup from the Tromsø Study with a more extensive examination, including ultrasonography of the carotid artery. In paper IV, we used a subgroup of participants with extended genetic analysis.
We found no association between atherosclerosis and risk of VTE. MI and stroke were associated with a transient risk of VTE, and individuals with MI had a particularly high risk of developing PE. After both MI and stroke, the risk was particularly high for provoked VTE events. We found a synergistic effect of ischemic stroke and prothrombotic genotypes on the risk of VTE. The risk increased gradually with the number of risk alleles.
Our findings imply that MI and ischemic stroke are associated with an increased transient risk of VTE, and that genetic risk factors are important in the development of VTE after stroke. The transient nature of the VTE risk suggests that indirect (e.g., hospitalization, immobilization) or direct (e.g. activation of the coagulation system) mechanisms related to the CVD are primarily responsible for the association.
Veiledere
Hovedveileder professor John-Bjarne Hansen
Biveileder førsteamanuensis Sigrid Brækkan
Bedømmelseskomiteen
Professor Henrik Toft Sørensen, Department of Clinical Epidemiology, Aarhus University Hospital, Danmark – 1. opponent
Førsteamanuensis Astrid van Hylckama Vlieg, Department of Clinical Epidemiology, Leiden University Medical Center, Nederland – 2. opponent
Professor Ragnar Joakimsen, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité
Disputasleder
Professor Gunnvald Kvarstein, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, Universitetet i Tromsø – Norges arktiske universitet
Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted: “Prevention and Treatment of venous thromboembolism: The past, the present and the future”