Master of Science Simin Jamaly disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:
“Role of Extracellular Vesicles in the Pathogenesis of Venous Thromboembolism”
Kort sammendrag av avhandlingen:
Extracellular vesicles (EVs) are vesicles with bilayer phospholipid membranes budded off from cells under various conditions. Recent advances in experimental and observational studies suggest a pivotal role of EVs in venous thromboembolism (VTE). We measured plasma levels and parental origin of P-Selectin Glycoprotein Ligand-1 positive (PSGL-1+) EVs in patients with unprovoked VTE, and found that high plasma PSGL-1+ EV levels were associated with increased risk of VTE. We also showed that plasma miRNA profiling could provide novel biomarkers for VTE. Further, we analyzed the effect of pre-analytical conditions on plasma concentrations and size distribution of EVs by Nanoparticle-Tracking Analysis (NTA) and found that the mean size of VLDL particles interfered with EV-measurements in the postprandial phase. We also developed a reliable and cost-effective modified assay to measure procoagulant phospholipid activity of EVs which will allow for large scale measurement of PPL activity. (Avhandlingen er tilgjengelig for utlån hos Seksjon for forskningstjenester frem til disputasdato)
Veiledere
Hovedveileder professor John-Bjarne Hansen
Biveileder førsteamanuensis Sigrid K. Brækkan
Biveileder førsteamanuensis Ellen E. Brodin
Bedømmelseskomiteen
Professor Tomas Lindahl, Linköpings Universitet, Sverige – 1. opponent
Forsker Reidun Øvstebø, Oslo Universitetssykehus – 2. opponent
Professor Gunnar Leivseth, UiT – Norges arktiske universitet – leder av komité
Disputasleder
Professor Christine Hanssen Rinaldo
Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted: “The role of Extracellular Vesicles in Health and Disease”