cand.med. Jon Widding Fjalstad disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:
“Antibiotic Therapy for Neonatal Sepsis - Studies on epidemiology, gentamicin safety, and early adverse effects of antibiotics. ”
Kort sammendrag av avhandlingen:
Neonatal sepsis is a rare, but potentially deadly bacterial infection that affects infants in the first month of life. We investigated neonatal sepsis and antibiotic use in all term born infants in Norway over a three-year period. We discovered that 2% of all Norwegian infants received antibiotics in their first week of life. Only half of them were ever diagnosed with an infection. Gentamicin is an antibiotic that has been linked with hearing loss and kidney failure in adults. When we studied this antibiotic in the neonatal unit in Tromsø, we found it be safe for infants. We also examined potential side-effects of antibiotic treatment in a systematic review. We found that antibiotics given to preterm infants can increase the risk of necrotizing enterocolitis (a very severe gut infection) and death, while some antibiotics increase the risk of serious fungal infection. Overuse of antibiotics causes increased development of antibiotic resistance and different changes in gut bacteria.
(Avhandlingen er tilgjengelig for utlån hos Seksjon forutdanningstjenester frem til disputasdato)
Veiledere
Hovedveileder professor Claus Andreas Klingenberg, Institutt for klinisk medisin, UiT Norges arktiske universitet.
Biveileder professor Trond Flægstad, Institutt for klinisk medisin, UiT Norges arktiske universitet
Bedømmelseskomiteen
1. Opponent: Dr. Alison Bedford Russel, Sidra Medicine, Doha, Qatar.
2. Opponent: Dosent Samuli Rautava, Department of Pediatrics, University of Turku.
Leder av komite: Professor Pål Johnsen, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Disputasleder
Professor Ruth Paulssen, Institutt for klinisk medisin, UiT Norges arktiske universitet
Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted: “Mechanisms by which peri-partum antibiotics may increase the risk of necrotizing enterocolitis (NEC)”