Immunologically trained fish larvae
Innate immune training offers an attractive approach in intensive fish larval rearing, especially since the adaptive immune system is not fully developed.
So-called immunostimulants such as ß-glucans have for decades been used both in laboratories and in intensive fish aquaculture. Treatment of fish by ß-glucans (and by other substances with pathogen-associated molecular patterns) often induces activation of non-specific/innate immune mechanisms and induces higher disease resistance. The reported effects of e.g. ß-glucans fit nicely into the concept “trained innate immunity”, but the research on fish does not yet include analysis of epigenetic changes that may be a prerequisite for long-lasting trained innate immunity. This project will approach whether innate training induce diseae resistance in fish larvae. PI: Roy A. Dalmo. Master student: Harald Kristoffersen.
opprettet: 12.02.2019 12:59