Inflammation in oral cancer

Cancer cells provoke an immune reaction, which may either promote or prevent tumor growth and spread, dependent on the immune cells involved, how they are stimulated and organized. In this project, we characterize the immune infiltrate through various phases of tumor evolution by use of tumor tissue form oral cancer patients as well as material from in vivo models. We also assess the organization and regulation of the immune infiltrate, and how these factors affect patient survival. The analyses involves a broad repertoire of methods, including immunohistochemistry, RT-qPCR, FACS, Luminex and proliferation and activity assays on isolated lymphocytes. The aim is to understand the characteristics and regulation of a tumor suppressive immune response. This may open for development of new immune modulatory therapy.

For more Information, please contact: Elin Hadler-Olsen: elin.hadler-olsen@uit.no