Reproductive toxicity and transgenerational effects of petroleum mixtures in fish (ToxiGen)

Welcome Aliza to the ToxiGen Team!

We are excited to welcome Aliza Naeem Rana, a master’s student from the University of Padova, Italy, who will be conducting her thesis research at the University of Bergen through the Erasmus+ program.

Studying the molecular effects of oil fractions 

Crude oil is made up of many different chemicals, some of which can be harmful to marine life. During these months, Aliza will investigate how five oil-derived fractions affect cod at the molecular level. She will also study the combined effects of all these chemicals, providing a more complete picture of oil toxicity.

How will she do it?

Aliza will focus on four key receptors from Atlantic cod that play a role in detoxification and reproduction. These proteins help the fish process harmful substances and maintain healthy biological functions. By using luciferase gene reporter assays, she will test how different oil components interact with these proteins and influence their activity. This will help determine which chemicals are most harmful and how they affect fish health.

Why is this research important?

Previous studies have shown that exposure to crude oil can activate certain stress-response genes in fish, suggesting a potential risk to their health. Aliza’s research will help us better understand which chemicals are responsible for these effects, contributing to improved environmental protection measures and policies for oil spills and pollution.

Welcome to Bergen, Aliza! 🎉🐟