Disputas Srijana Bastakoti Belbase

Lenke til avhandlingen/the doctoral thesis

Prøveforelesning

Disputas

Opptak av disputasen vil være tilgjengelig i et døgn.

A recording of the defense will be available for 24 hours.

Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted:

“The duality of Staphylococcus aureus as a human commensal and a major human pathogen”

Prøveforelesningen vil også bli strømmet/the trial lecture will also be streamed

Populærvitenskapelig sammendrag av avhandlingen:

Trillions of bacteria inhabit our bodies, usually friendly but sometimes can turn against us and cause serious diseases. Staphylococcus aureus is one such bacterium, commonly present in the nose and throat but also able to cause infections like pneumonia and bloodstream infections. This study has shed light on the possible identification of tools (genes) used by S. aureus both for living in the human throat and during infection. This was mimicked in a laboratory setting, where we took a closer look at how S. aureus behaves at a genetic level when it meets and mingles with human cells and other bacteria living in the throat. We used an advanced technique revealing the bacterial gene signature. In this way, we have spotted S. aureus’ genes which are necessary for entering cells and for survival. By understanding the role of these genes, we might be able to find new ways to tackle S. aureus colonization and infections.

Hovedveileder

Førsteamanuensis Anne-Merethe Hanssen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Biveileder

Professor Mona Johannessen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Postdoktor Clément Ajayi, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Bedømmelseskomité

Professor Francois Vandenesch Lyon University Medical School / Centre International de Recherche en Infectiologie – 1. Opponent

Forsker Christina Gabrielsen Ås, St. Olavs hospital- 2. opponent

Førsteamanuensis Elizabeth Aarag Fredheim, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité

Disputasleder:

Professor Johanna U. Ericson, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet