Master of Science Sabin Bhandari ved Institutt for medisinsk biologi disputerer for ph.d.-grad i helsevitenskap og vil offentlig forsvare avhandlingen:
“Molecular profiling of the liver sinusoidal endothelial cell – a multi-omics approach”
Sammendrag av avhandlingen finner du nederst på dette arrangementet.
De som ønsker å opponere ex auditorio kan sende e-post til disputasleder Kirsti Ytrehus.
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På grunn av koronautbruddet er auditoriet stengt for publikum. Disputasen vil bli strømmet her.Opptak av disputasen vil være tilgjengelig i 24 timer. |
Prøveforelesning
Prøveforelesningen "Plasma proteomics and diagnosis of disease" holdes kl. 10.15.
Prøveforelesningen vil bli strømmet her.
Bedømmelseskomité
1. opponent: Professor Staffan Johanson, Uppsala University, Department of Medical Biochemistry and Microbiology.
2. opponent: Professor Tor Gjøen, University of Oslo, Department of Pharmacy Norway.
Leder av komité: Professor Kristin Andreassen Fenton, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Hovedveileder: Professor Karen Kristine Sørensen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Disputasleder: Professor Kirsti Ytrehus, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Populærvitenskapelig sammendrag av avhandlingen:The endothelium is the innermost cell layer of blood vessels. Besides the general role to prevent blood coagulation and regulate blood flow, endothelial cells show tissue-specific specializations. This thesis describes a unique endothelial cell with immune-like properties, namely the liver sinusoidal endothelial cell (LSEC). LSECs are important scavenger cells eliminating microbial products, viruses, and waste substances from the blood. In his thesis, Bhandari used a multi-omics profiling approach to reveal the molecular phenotype of rat and mouse LSECs, two model species in medical research. Bhandari studied LSECs under various conditions and compared the cells with another important cell in host defense, namely liver macrophages. His findings revealed complementary and partly overlapping scavenging and immune functions of the two cells. This thesis also provides a detailed overview of the effects of the important anti-inflammatory drug dexamethasone on LSEC protein expression and functions. |
Master of Science Sabin Bhandari at the Department of Medical Biology is defending his doctoral dissertation in health sciences and will publicly defend the thesis:
“Molecular profiling of the liver sinusoidal endothelial cell – a multi-omics approach”
Opponents ex auditorio should sign up to leader of defense by e-mail to: kirsti.ytrehus@uit.no
The auditorium will be closed to the public because of the corona outbreak.
The defense will be streamed here.
The recording will be available for 24 hours.
Trial lecture
The trial lecture "Plasma proteomics and diagnosis of disease" will be held at 10.15 AM.
The trail lecture will be streamed here
Popular scientific summary of the thesis:The endothelium is the innermost cell layer of blood vessels. Besides the general role to prevent blood coagulation and regulate blood flow, endothelial cells show tissue-specific specializations. This thesis describes a unique endothelial cell with immune-like properties, namely the liver sinusoidal endothelial cell (LSEC). LSECs are important scavenger cells eliminating microbial products, viruses, and waste substances from the blood. In his thesis, Bhandari used a multi-omics profiling approach to reveal the molecular phenotype of rat and mouse LSECs, two model species in medical research. Bhandari studied LSECs under various conditions and compared the cells with another important cell in host defense, namely liver macrophages. His findings revealed complementary and partly overlapping scavenging and immune functions of the two cells. This thesis also provides a detailed overview of the effects of the important anti-inflammatory drug dexamethasone on LSEC protein expression and functions. |
Når: 20.08.21 kl 10.15–15.00
Hvor: Auditorium Cortex
Sted: Digitalt, Tromsø
Målgruppe: Ansatte, Studenter, Gjester / eksterne, Inviterte, Enhet
Kontakt: Andrea Jennerwein
E-post: andrea.jennerwein@uit.no