Foto: INGAR LEIROS
Ingar Leiros
Madan Junghare,
Tamilvendan Manavalan,
Lasse Fredriksen,
Ingar Leiros,
Bjørn Altermark,
Vincent Eijsink
m.fl.:
Biochemical and structural characterisation of a family GH5 cellulase from endosymbiont of shipworm P. megotara
Marina Alexeeva,
Marivi Nabong Moen,
Xiang Ming Xu,
Anette Rasmussen,
Ingar Leiros,
Finn Kirpekar
m.fl.:
Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification
Heidi Therese Hillier,
Bjørn Altermark,
Ingar Leiros
:
The crystal structure of the tetrameric DABA-aminotransferase EctB, a rate-limiting enzyme in the ectoine biosynthesis pathway.
Kristin Grøsvik,
Almaz Nigatu Tesfahun,
Izaskun Muruzábal-Lecumberri,
Gyri Teien Haugland,
Ingar Leiros,
Peter Ruoff
m.fl.:
The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside
Kristel Berg,
Hege Lynum Pedersen,
Ingar Leiros
:
Biochemical characterization of ferric uptake regulator (Fur) from Aliivibrio salmonicida. Mapping the DNA sequence specificity through binding studies and structural modelling
Kristel Berg,
Ingar Leiros,
Adele Kim Williamson
:
Temperature adaptation of DNA ligases from psychrophilic organisms
Yvonne Piotrowski,
Kristel Berg,
David P. Klebl,
Ingar Leiros,
Atle Noralf Larsen
:
Characterization of an intertidal zone metagenome oligoribonuclease and the role of the intermolecular disulfide bond for homodimer formation and nuclease activity
Gro Elin Kjæreng Bjerga,
Øivind Larsen,
Hasan ARSIN,
Adele Kim Williamson,
Antonio Garcia-Moyano,
Ingar Leiros
m.fl.:
Mutational analysis of the pro-peptide of a marine intracellular subtilisin protease supports its role in inhibition
Marianne Slang Jensen,
Lasse Fredriksen,
Alasdair Mackenzie,
Phillip Pope,
Ingar Leiros,
Piotr Chylenski
m.fl.:
Discovery and characterization of a thermostable two-domain GH6 endoglucanase from a compost metagenome
Miriam Grgic,
Adele Kim Williamson,
Gro Elin Kjæreng Bjerga,
Bjørn Altermark,
Ingar Leiros
:
Biochemical characterization of ParI, an orphan C5-DNA methyltransferase from Psychrobacter arcticus 273-4
Hege Lynum Pedersen,
Kenneth Johnson,
Colin McVey,
Ingar Leiros,
Elin Moe
:
Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA
Elin Moe,
Netsanet Gizaw Assefa,
Ingar Leiros,
Kathrin Torseth,
Arne O. Smalås,
Nils Peder Willassen
:
Reduced Hydrophobicity of the Minor Groove Intercalation Loop is Critical for Efficient Catalysis by Cold Adapted Uracil-DNA N-Glycosylase from Atlantic Cod
Journal of Thermodynamics & Catalysis 2015 DOI
Anders Kristiansen,
Miriam Grgic,
Bjørn Altermark,
Ingar Leiros
:
Properties and distribution of a metallo-β-lactamase (ALI-1) from the fish pathogen Aliivibrio salmonicida LFI1238
Hanna-Kirsti S. Leiros,
Susann Skagseth,
Kine Susann Waade Edvardsen,
Marit Sjo Lorentzen,
Gro Elin Kjæreng Bjerga,
Ingar Leiros
m.fl.:
His224 alters the R2 drug binding site and Phe218 influences the catalytic efficiency of the metallo-β-lactamase VIM-7
Antimicrobial Agents and Chemotherapy 2014 DOI
Elin Moe,
D R Hall,
Ingar Leiros,
Vivi Talstad Monsen,
Joanna Timmins,
Sean McSweeney
:
Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans
Acta Crystallographica Section D: Biological Crystallography 2012 DOI
Hanna-Kirsti S. Leiros,
Anita-Elin Fedøy,
Ingar Leiros,
Ida Helene Steen
:
The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila support a new active site locking mechanism
Pardha Saradhi,
Hanna-Kirsti S. Leiros,
Rafi Ahmad,
James Spencer,
Ingar Leiros,
Timothy R. Walsh
m.fl.:
Structural and Computational Investigations of VIM-7: Insights into the Substrate Specificity of VIM Metallo-beta-Lactamases
Journal of Molecular Biology (JMB) 2011 DOI
hege lynum Pedersen,
Rafi Ahmad,
EK Riise,
Hanna-Kirsti S. Leiros,
Stefan Hauglid,
S Espelid
m.fl.:
Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida)
Journal of Microbiology 2010 DOI
Inger Lin Uttakleiv Ræder,
Elin Moe,
Nils Peder Willassen,
Arne Oskar Smalås,
Ingar Leiros
:
Structure of uracil-DNA N-glycosylase (UNG) from Vibrio cholerae: mapping temperature adaptation through structural and mutational analysis
Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2010 DOI
In-Ja L. Byeon,
Khanh Kim Dao,
Jinwon Jung,
Thomas Jeffrey Keen,
Ingar Leiros,
Stein Ove Doskeland
m.fl.:
Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR
Journal of Biological Chemistry 2010 DOI
Ingeborg Knævelsrud,
Marivi Moen,
Kristin Grøsvik,
Gyri Teien Haugland,
Nils-Kåre Birkeland,
Arne Klungland
m.fl.:
The Hyperthermophilic Euryarchaeon Archaeoglobus fulgidus Repairs Uracil by Single-Nucleotide Replacement
Journal of Bacteriology 2010 DOI
AB Robertson,
A Klungland,
T Rognes,
Ingar Leiros
:
DNA Repair in Mammalian Cells
Cellular and Molecular Life Sciences (CMLS) 2009 DOI
I Knaevelsrud,
I Knaevelsrud,
G Slupphaug,
Ingar Leiros,
A Matsuda,
P Ruoff
m.fl.:
Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1
International Journal of Radiation Biology 2009 DOI
hege lynum Pedersen,
Nils Peder Willassen,
Ingar Leiros
:
The first structure of a cold-adapted superoxide dismutase (SOD): biochemical and structural characterization of iron SOD from Aliivibrio salmonicida
Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2009 DOI
Heidi Therese Hillier,
Bjørn Altermark,
Ingar Leiros
:
Enzymes in The Ectoine Biosynthesis Pathway
2020
Susann Trondsen,
Ingar Leiros,
Bjørn Altermark
:
Expression and characterization of wood-degrading enzymes from a shipworm digestive system
2020
Susann Trondsen,
Ingar Leiros,
Inger Lin Uttakleiv Ræder,
Seila Pandur,
Bjørn Altermark
:
Tapping into the proteome of shipworm symbionts - a novel source of cold-adapted lignocellulases
2019
Heidi Therese Hillier,
Bjørn Altermark,
Ingar Leiros
:
Characterizing Enzymes in The Ectoine Biosynthesis Pathway
2019
Heidi Therese Hillier,
Bjørn Altermark,
Ingar Leiros
:
Characterizing Enzymes in The Ectoine Biosynthesis Pathway
2019
Heidi Therese Hillier,
Ingar Leiros,
Bjørn Altermark
:
Characterizing Enzymes in The Ectoine Biosynthesis Pathway
2019
Heidi Therese Hillier,
Bjørn Altermark,
Ingar Leiros
:
Enzymes in the ectoine biosynthesis pathway
2019
Susann Trondsen,
Bjørn Altermark,
Ingar Leiros
:
Shipworm-associated bacteria - A novel source of cold-adapted wood-degrading enzymes
2019
Susann Trondsen,
Ingar Leiros,
Bjørn Altermark
:
Shipworm-associated bacteria - a novel source of cold-adapted wood-degrading enzymes
2019
Adele Kim Williamson,
Erik Hjerde,
Aili Sarre,
Ingar Leiros,
Kristel Berg,
Hanna-Kirsti S. Leiros
:
Discovery and design of novel DNA ligases for biotechnology
2018
Heidi Therese Hillier,
Bjørn Altermark,
Ingar Leiros
:
Ectoine: an osmolyte from the model organism Chromohalobacter salexigens
2018
Heidi Therese Hillier,
Bjørn Altermark,
Ingar Leiros
:
Characterizing enzymes in the biosynthesis pathway of Ectoine
2018
Man Kumari Gurung,
Tor Olav Berg,
Marie-Josée Haglund Halsør,
Bjørn Altermark,
Ingar Leiros,
Ronny Helland
m.fl.:
Efficient production of sialic acids- Using enzymes for biomass conversion
2017
Man Kumari Gurung,
Tor Olav Berg,
Marie-Josée Haglund Halsør,
Bjørn Altermark,
Ingar Leiros,
Ronny Helland
m.fl.:
Efficient production of sialic acids- Using enzymes for biomass conversion
2017
Øivind Larsen,
Hasan Arsin,
Runar Stokke,
Antonio Garcia-Moyano,
Pål Puntervoll,
Ingar Leiros
m.fl.:
Discovery of proteases for bioconversion of marine biomass
2017
Tor Olav Berg,
Bjørn Altermark,
Ingar Leiros,
Ronny Helland,
Inger Lin Uttakleiv Ræder
:
Production of sialic acids and derivatives by enzyme catalysis
2016
Tor Olav Berg,
Marie-Josée Haglund Halsør,
Man Kumari Gurung,
Bjørn Altermark,
Ingar Leiros,
Ulli Rothweiler
m.fl.:
From marine rest raw materials to sialic acids: Using enzymes for biomass conversion
2016
Elin Moe,
Ingar Leiros,
David Hall,
Aili Sarre,
Arne O. Smalås,
Sean McSweeney
m.fl.:
Base Excision Repair (BER) in Deinococcus radiodurans
2015
Tor Olav Berg,
Bjørn Altermark,
Ingar Leiros,
Ronny Helland,
Inger Lin Uttakleiv Ræder
:
Biocatalytical production of sialic acids and derivatives
2015
Susann Skagseth,
Kine Susann Waade Edvardsen,
Gro Elin Kjæreng Bjerga,
marit sjo Lorentzen,
Ingar Leiros,
Ørjan Samulesen
m.fl.:
Site-directed mutagenesis of metallo-beta-lactamase VIM-7 from the opportunistic human pathogenic bacteria Pseudomonas aeruginosa
2013
Man Kumari Gurung,
Inger Lin Uttakleiv Ræder,
Bjørn Altermark,
Ingar Leiros,
Mats Ökvist,
Arne O. Smalås
:
Exploring sialic acid synthesizing enzymes from Aliivibrio salmonicida
2012
Miriam Grgic,
Gro Elin Kjæreng Bjerga,
Bjørn Altermark,
Ingar Leiros
:
C5-methyltransferase from cold-adapted organism
2012
Mats Ökvist,
Inger Lin Uttakleiv Ræder,
Ingar Leiros,
Arne O. Smalås
:
Structure of Sialic Acid Biosynthesis Enzyme PtmG from Aliivibrio Salmonicida
2011
Mats Ökvist,
Inger Lin Uttakleiv Ræder,
Ingar Leiros,
Arne O. Smalås
:
Structure of sialic acid biosynthesis enzyme PtmG from Aliivibrio salmonicida
2011
Inger Lin Uttakleiv Ræder,
Man Kumari Gurung,
Bjørn Altermark,
Ingar Leiros,
Mats Ökvist,
Arne O. Smalås
:
Sialic acid biosynthesis in Aliivibrio salmonicida
2011
Man Kumari Gurung,
Inger Lin Uttakleiv Ræder,
Bjørn Altermark,
Ingar Leiros,
Mats Ökvist,
Arne O. Smalås
:
Sialic acid biosynthesis in Aliivibrio salmonicida
2011
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Forskningsinteresser
Undervisning
- Project leader: BioCat (2016-2024). BioCat is a national graduate school in biocatalysis, granted by The Norwegian Research Council. It is established to provide expertise and tools for research and research education within biocatalysis in Norway. The school is open to all PhD-students and their research groups within the field. Biocatalysis is important in many areas including biomedicine, biotechnology, microbiology, and (bio)nanoscience. Additionally, biocatalysis is becomming increasingly important industrial processes and in various diagnostics-, gene- and biotechnologies, and is expected to be important in the transition of the society to a bio-based economy. Six Norwegian universities, 4 research institutes and the Industrial Biotechnology Network Norway, constitute the BioCat consortium. This collaboration represents a unification of many strong research groups, giving the students great access to both the expertise, facilities and training offered by the Norwegian biocatalysis research community.