Cognitive dysfunction in primary hyperparathyroidism

Primary hyperparathyroidism PHPT is a fairly common endocrine disorder affecting 0,1-0,7 % of the population. The disease is caused by adenomas in the parathyroid glands, causing increased systemic calcium levels by increased bone resorption, increased gut absorption and calcium retention by the kidneys. A wide range of symptoms and diseases have been linked with PHPT in associational studies, including cardiovascular disease, cerebrovascular disease, renal failure, renal stones, psychiatric disease, hypertension, fractures, cancer and diabetes. In this project, we will search for the neural mechanisms behind cognitive and psychiatric symptoms in PHPT.