Encoding of non-spatial information in the hippocampus

Generalization of aversive memories after trauma or severe illness has been the proposed mechanism for emotional disorders such as posttraumatic stress disorder (PTSD). The hippocampus and stress hormone (CORT) has been implied in the formation of fear memories and anxiety related behavior, but the details are far from understood. CORT at an optimal plasma level is known to enhance and modulate memory formation, promoting emotional information. However, sufficient levels of CORT also seem to play a role in extinction of such memories, necessary for a healthy mental recovery. The goal of this project is to understand how emotional valence is added to a memory in the brain. The project is funded by the Norwegian Research Council and UiT.