Bilde av Rothweiler, Ulli
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Ulli Rothweiler


Forsker, Biomolekylær og strukturkjemi

Vitenskapelige arbeidsområder


  • Agata Barzowska, Barbara Pucelik, Katarzyna Pustelny, Alex Matsuda, Alicja Martyniak, Jacek Stępniewski m.fl.:
    DYRK1A kinase inhibitors promote β-cell survival and insulin homeostasis
    Cells 2021 FULLTEKST / ARKIV / DOI
  • Wenche Stensen, Ulli Rothweiler, Richard Alan Engh, Melissa R. Stasko, Ilya Bederman, Alberto C. S. Costa m.fl.:
    Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome
    Pharmaceuticals 2021 ARKIV / FULLTEKST / DOI
  • Pankaj Jadhav, Vikrant Sinha, Saurabh Chugh, Chaithanya Kotyada, Digvijay Bachhav, Ramandeep Singh m.fl.:
    2.09 Å resolution structure of E. coli HigBA toxin-antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitoxin
    Biochemical Journal 2020 DOI
  • Marie-Josée Haglund Halsør, Ulli Rothweiler, Bjørn Altermark, Inger Lin Uttakleiv Ræder :
    The crystal structure of the N-acetylglucosamine 2-epimerase from Nostoc sp. KVJ10 reveals the true dimer
    Acta Crystallographica Section D: Structural Biology 2019 ARKIV / DOI
  • Ronny Helland, Eva katrin Bjørkeng, Ulli Rothweiler, Magne Olav Sydnes, Daniela Maria Pampanin :
    The crystal structure of haemoglobin from Atlantic cod
    Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2019 ARKIV / DOI
  • Anna Lucja Czarna, Wang Jinhua, Diana Zelencova, Yao Liu, Xianming Deng, Hwan Geun Choi m.fl.:
    Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors
    Journal of Medicinal Chemistry 2018 ARKIV / DOI
  • Tina Rise Tuveng, Ulli Rothweiler, D.B.R.K. Gupta Udatha, Gustav Vaaje-Kolstad, Arne O. Smalås, Vincent Eijsink :
    Structure and function of a CE4 deacetylase isolated from a marine environment
    PLOS ONE 06. november 2017 ARKIV / DOI
  • Ulli Rothweiler, Wenche Stensen, Bjørn Olav Brandsdal, Johan Isaksson, Frederick Alan Leeson, Richard Alan Engh m.fl.:
    Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules
    Journal of Medicinal Chemistry 2016 DOI
  • Ulli Rothweiler, Jonas Eriksson, Wenche Stensen, Frederick Alan Leeson, Richard Alan Engh, John Sigurd Svendsen :
    Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors
    European Journal of Medicinal Chemistry 2015 DOI
  • Marina Alexeeva, espen Åberg, Richard Alan Engh, Ulli Rothweiler :
    The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.
    Acta Crystallographica Section D: Biological Crystallography 2015 ARKIV / DOI
  • Osman A.B.S.M. Gani, Balmukund Thakkar, Dilip Narayanan, Kazi Asraful Alam, Peter Kyomuhendo, Ulli Rothweiler m.fl.:
    Assessing protein kinase target similarity: Comparing sequence, structure, and cheminformatics approaches
    Biochimica et Biophysica Acta - Proteins and Proteomics 2015 FULLTEKST / DOI
  • Adele Kim Williamson, Ulli Rothweiler, Hanna-Kirsti S. Leiros :
    Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface
    Acta Crystallographica Section D: Biological Crystallography 2014 ARKIV / DOI
  • espen Åberg, Bjarte Aarmo Lund, Alexander Pflug, Osman A.B.S.M. Gani, Ulli Rothweiler, Taiana Maia De Oliveira m.fl.:
    Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool
    Biological chemistry 2012 DOI
  • Michael Orth, Bernd Mayer, Kinga Rehm, Ulli Rothweiler, Doris Heidmann, Tad A Holak m.fl.:
    Shugoshin is a Mad1/Cdc20-like interactor of Mad2
    EMBO Journal 2011 DOI
  • Ulli Rothweiler, espen Åberg, Kenneth Johnson, Tom Egil Hansen, Jorunn B Jørgensen, Richard Alan Engh :
    p38 alpha MAP Kinase Dimers with Swapped Activation Segments and a Novel Catalytic Loop Conformation
    Journal of Molecular Biology (JMB) 2011 DOI
  • Ulli Rothweiler, Anna Lucja Czarna, Lutz Weber, Grzegorz Popowicz, Kinga Brongel, Kaja Kowalska m.fl.:
    NMR Screening for Lead Compounds Using Tryptophan-Mutated Proteins
    Journal of Medicinal Chemistry 2008
  • Ulli Rothweiler, Anna Lucja Czarna, Marcin Krajewski, Jolanta Ciombor, Cédric Kalinski, Vladimir Khazak m.fl.:
    Isoquinolin-1-one Inhibitors of the MDM2–p53 Interaction
    ChemMedChem 2008
  • Marcin Krajewski, Ulli Rothweiler, Loyola D'Silva, Sudipta Majumdar, Christian Klein, Tad A Holak :
    An NMR-based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments.
    Journal of Medicinal Chemistry 2007
  • Grzegorz Popowicz, Anna Lucja Czarna, Ulli Rothweiler, Aleksandra Szwagierczak, Marcin Krajewski, Lutz Weber m.fl.:
    Molecular Basis for the Inhibition of p53 by Mdmx
    Cell Cycle 2007
  • Loyola D'Silva, Przemyslaw Ozdowy, Marcin Krajewski, Ulli Rothweiler, Mahavir Singh, Tad A Holak :
    Monitoring the Effects of Antagonists on Protein−Protein Interactions with NMR Spectroscopy
    Journal of the American Chemical Society 2005
  • Marcin Krajewski, Przemyslaw Ozdowy, Loyola D'Silva, Ulli Rothweiler, Tad A Holak :
    NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro
    Nature Medicine 2005
  • Man Kumari Gurung, Tor Olav Berg, Marie-Josée Haglund Halsør, Bjørn Altermark, Ingar Leiros, Ronny Helland m.fl.:
    Efficient production of sialic acids- Using enzymes for biomass conversion
    2017
  • Man Kumari Gurung, Tor Olav Berg, Marie-Josée Haglund Halsør, Bjørn Altermark, Ingar Leiros, Ronny Helland m.fl.:
    Efficient production of sialic acids- Using enzymes for biomass conversion
    2017
  • Tor Olav Berg, Marie-Josée Haglund Halsør, Man Kumari Gurung, Bjørn Altermark, Ingar Leiros, Ulli Rothweiler m.fl.:
    From marine rest raw materials to sialic acids: Using enzymes for biomass conversion
    2016
  • Kazi Asraful Alam, Ulli Rothweiler, Richard Alan Engh :
    Static and dynamic interactions between the glycine-rich loop of protein kinases and ATP site inhibitors
    2016
  • Marcin Miroslaw Pierechod, Ulli Rothweiler, Taianá Maia de Oliveira :
    The structure of Salinibacter ruber Single‐Strand Binding protein reveals a novel, octameric architecture of bacterial SSB proteins
    2016
  • Ulli Rothweiler :
    DYRK1A-PKC412 complex - disulfide-bridge formation with an anomalous catalytic loop HRD(HCD) cysteine
    2016
  • Marina Alexeeva, espen Åberg, Richard Alan Engh, Ulli Rothweiler :
    The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.
    2016
  • Ulli Rothweiler :
    Drug discovery and design: from the deep ocean to the bedside.
    2016

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    Forskningsinteresser

    Biophysical characterization of enzymes and kinases involved in neurodegenerative diseases