Bilde av Lamark, Trond
Bilde av Lamark, Trond
Institutt for medisinsk biologi trond.lamark@uit.no +4777646833 40634594 Tromsø MH L9.235

Trond Lamark


Forsker


  • Juncal Garcia Garcia, Anne Kristin McLaren Berge, Katrine Stange Overå, Kenneth Bowitz Larsen, Zambarlal Babanrao Bhujabal, Andreas Brech m.fl.:
    TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1
    The FEBS Journal 2022 ARKIV / DOI
  • Nikoline Lander Rasmussen, Athanasios Kournoutis, Trond Lamark, Terje Johansen :
    NBR1: The archetypal selective autophagy receptor
    Journal of Cell Biology 2022 ARKIV / DOI
  • Thaddaeus Mutugi Nthiga, Birendra Kumar Shrestha, Trond Lamark, Terje Johansen :
    The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor.
    Autophagy 2021 ARKIV / DOI
  • Yakubu Princely Abudu, Stephane Mouilleron, Sharon A Tooze, Trond Lamark, Terje Johansen :
    SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy
    Autophagy 2021 ARKIV / DOI
  • Thaddaeus Mutugi Nthiga, Birendra Kumar Shrestha, Jack-Ansgar Bruun, Kenneth Bowitz Larsen, Trond Lamark, Terje Johansen :
    Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy
    Journal of Cell Biology 2021 ARKIV / DOI
  • Trond Lamark, Terje Johansen :
    Mechanisms of Selective Autophagy
    Annual Review of Cell and Developmental Biology 2021 ARKIV / DOI
  • Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Khaled Abdellatif, Asghar Abdoli, Yakubu Princely Abudu m.fl.:
    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
    Autophagy 2021 DOI
  • Yakubu Princely Abudu, Birendra Kumar Shrestha, Wenxin Zhang, Anthimi Palara, Hanne Britt Brenne, Kenneth Bowitz Larsen m.fl.:
    SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components
    Journal of Cell Biology 2021 ARKIV / DOI
  • Thaddaeus Mutugi Nthiga, Birendra Kumar Shrestha, Eva Sjøttem, Trond Lamark, Terje Johansen :
    CALCOCO1 acts with VAMP ‐associated proteins to mediate ER ‐phagy
    EMBO Journal 2020 ARKIV / DOI
  • Thaddaeu Mutugi Nthiga, Birendra Kumar Shrestha, Trond Lamark, Terje Johansen :
    CALCOCO1 is a soluble reticulophagy receptor
    Autophagy 2020 DOI
  • Arjen J. Jakobi, Stefan T. Huber, Simon A. Mortensen, Sebastian Schultz, Anthimi Palara, Tanja Kuhm m.fl.:
    Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
    Nature Communications 2020 ARKIV / DOI
  • Terje Johansen, Trond Lamark :
    Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors
    Journal of Molecular Biology (JMB) 2019 ARKIV / DOI
  • Yakubu Princely Abudu, Serhiy Pankiv, Benan John Mathai, Alf Håkon Lystad, Christian Bindesbøll, Hanne Britt Brenne m.fl.:
    NIPSNAP1 and NIPSNAP2 act as “eat-me signal” for mitophagy
    Developmental Cell 11. april 2019 ARKIV / DOI
  • Gry Hoem, Kenneth Bowitz Larsen, Aud Karin Øvervatn, Andreas Brech, Trond Lamark, Eva Sjøttem m.fl.:
    The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS
    Frontiers in Genetics 2019 ARKIV / DOI
  • Birendra Kumar Shrestha, Mads Skytte Rasmussen, Yakubu Princely Abudu, Jack-Ansgar Bruun, Kenneth Bowitz Larsen, Endalkachew Ashenafi Alemu m.fl.:
    NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1
    Journal of Biological Chemistry 2019 ARKIV / DOI
  • Åsa birna Birgisdottir, Stephane Mouilleron, Zambarlal Bhujabal, Martina Wirth, Eva Sjøttem, Gry Evjen m.fl.:
    Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs
    Autophagy 2019 ARKIV / DOI
  • Katrine Stange Overå, Juncal Garcia Garcia, Zambarlal Bhujabal, Ashish Jain, Aud Karin Øvervatn, Kenneth Bowitz Larsen m.fl.:
    TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1
    Journal of Cell Science 02. desember 2019 ARKIV / DOI
  • Yakubu Princely Abudu, Serhiy Pankiv, Benan John Mathai, Trond Lamark, Terje Johansen, Anne Simonsen :
    NIPSNAP1 and NIPSNAP2 act as “eat me” signals to allow sustained recruitment of autophagy receptors during mitophagy
    Autophagy 2019 DOI
  • Mads Skytte Rasmussen, Stephane Mouilleron, Birendra Kumar Shrestha, Martina Wirth, Rebecca Lee, Kenneth Bowitz Larsen m.fl.:
    ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8
    Autophagy 2017 DOI
  • Zambarlal Bhujabal, Åsa birna Birgisdottir, Eva Sjøttem, Hanne Britt Brenne, Aud Karin Øvervatn, Sabrina Habisov m.fl.:
    FKBP8 recruits LC3A to mediate Parkin-independent mitophagy
    EMBO Reports 05. april 2017 DOI
  • Trond Lamark, Steingrim Svenning, Terje Johansen :
    Regulation of selective autophagy: the p62/SQSTM1 paradigm
    Essays in Biochemistry 2017 DOI
  • Zhixun Dou, Caiyue Xu, Greg Donahue, Takeshi Shimi, Ji-An Pan, Jiajun Zhu m.fl.:
    Autophagy mediates degradation of nuclear lamina
    Nature 2015 DOI
  • Hallvard Lauritz Olsvik, Trond Lamark, Kenji Takagi, Kenneth Bowitz Larsen, gry Evjen, Aud Karin Øvervatn m.fl.:
    FYCO1 contains a C-terminally extended, LC3A/B-preferring LC3-interacting region (LIR) motif required for efficient maturation of autophagosomes during basal autophagy
    Journal of Biological Chemistry 2015 ARKIV / DOI
  • Rodolfo Ciuffa, Trond Lamark, Abul K. Tarafder, Audrey Guesdon, Sofia Rybina, Wim J.H. Hagen m.fl.:
    The Selective Autophagy Receptor p62 Forms a Flexible Filamentous Helical Scaffold
    Cell reports 2015 ARKIV / DOI
  • Ashish Jain, Tor Erik Rusten, Nadja Sandra Katheder, Julianne Elvenes, Jack-Ansgar Bruun, Eva Sjøttem m.fl.:
    P62/sequestosome-1, autophagy-related gene 8, and autophagy in Drosophila are regulated by nuclear factor erythroid 2-related factor 2(NRF2), independent of transcription factor TFEB
    Journal of Biological Chemistry 2015 ARKIV / DOI
  • Åsa birna Birgisdottir, Trond Lamark, Terje Johansen :
    The LIR motif - crucial for selective autophagy
    Journal of Cell Science 2013 DOI
  • Elizabeth Deosaran, Kenneth Bowitz Larsen, Rong Hua, Graeme Sargent, Yuqing Wang, Sarah Kim m.fl.:
    NBR1 acts as an autophagy receptor for peroxisomes
    Journal of Cell Science 2013 DOI
  • Ana Sancho, Jordi Duran, Antonio Garcia-Espana, Caroline Mauvezin, Endalkachew Ashenafi Alemu, Trond Lamark m.fl.:
    DOR/Tp53inp2 and Tp53inp1 Constitute a Metazoan Gene Family Encoding Dual Regulators of Autophagy and Transcription
    PLOS ONE 2012 ARKIV / DOI
  • Trond Lamark, Terje Johansen :
    Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy
    International Journal of Cell Biology 2012 ARKIV / DOI
  • Henning Kleine, Andreas Herrmann, Trond Lamark, Alexandra H. Forst, Patricia Verheugd, Juliane Lüscher-Firzlaff m.fl.:
    Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62
    Cell Communication and Signaling 2012 FULLTEKST / ARKIV / DOI
  • Endalkachew Ashenafi Alemu, Trond Lamark, Knut Martin Torgersen, Åsa birna Birgisdottir, Kenneth Bowitz Larsen, Ashish Jain m.fl.:
    ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex SEQUENCE REQUIREMENTS FOR LC3-INTERACTING REGION (LIR) MOTIFS
    Journal of Biological Chemistry 2012 ARKIV / DOI
  • Daniel J. Klionsky, FC Abdalla, H Abeliovich, RT Abraham, A Acevedo-Arozena, K Adeli m.fl.:
    Guidelines for the use and interpretation of assays for monitoring autophagy
    Autophagy 2012 DOI
  • Steingrim Svenning, Trond Lamark, Kirsten Krause, Terje Johansen :
    Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1
    Autophagy 2011 DOI
  • Terje Johansen, Trond Lamark :
    Selective autophagy mediated by autophagic adapter proteins
    Autophagy 2011 DOI
  • Serliy Pankiv, Endalkachew Alemu, Andreas Brech, Jack-Ansgar Bruun, Trond Lamark, Aud Karin Øvervatn m.fl.:
    FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport
    Journal of Cell Biology 2010 DOI
  • Serliy Pankiv, Trond Lamark, Jack-Ansgar Bruun, Aud Karin Øvervatn, Geir Bjørkøy, Terje Johansen :
    Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies
    Journal of Biological Chemistry 2010 DOI
  • Maria Filimonenko, Pauline Isakson, Kim D Finley, Monique Anderson, Hyun Jeong, Thomas J Melia m.fl.:
    The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy
    Molecular Cell 2010 DOI
  • Trond Lamark, Terje Johansen :
    Autophagy: links with the proteasome
    Current Opinion in Cell Biology 2010 DOI
  • Ashish Jain, Trond Lamark, Eva Sjøttem, Kenneth Bowitz Larsen, Jane Atesoh Awuh, Aud Karin Øvervatn m.fl.:
    p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
    Journal of Biological Chemistry 2010 DOI
  • Kenneth Bowitz Larsen, Trond Lamark, Aud Karin Øvervatn, Ingvill Harneshaug, Terje Johansen, Geir Bjørkøy :
    A reporter cell system to monitor autophagy based on p62/SQSTM1
    Autophagy 2010
  • Ioannis Nezis, Bhupendra V Shravage, Antonia Sagona, Trond Lamark, Geir Bjørkøy, Terje Johansen m.fl.:
    Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis
    Journal of Cell Biology 2010 DOI
  • Terje Clausen, Trond Lamark, Pauline Isakson, Kim Finley, Kenneth Bowitz Larsen, Andreas Brech m.fl.:
    p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy
    Autophagy 2010 DOI
  • Ioannis P Nezis, Trond Lamark, Athanassios D Velentzas, Tor Erik Rusten, Geir Bjørkøy, Terje Johansen m.fl.:
    Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy
    Autophagy 2009
  • Y Zheng, S Shahnazari, Andreas Brech, Trond Lamark, Terje Johansen, JH Brumell :
    The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway
    Journal of Immunology 2009 DOI
  • Trond Lamark, Vladimir Kirkin, Ivan Dikic, Terje Johansen :
    NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets
    Cell Cycle 2009
  • Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen m.fl.:
    TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
    2021
  • Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen m.fl.:
    TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
    2021
  • Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen m.fl.:
    TNIP1 is degraded by selective autophagy upon proinflammatory signalling
    2021
  • Terje Johansen, Trond Lamark :
    Selective autophagy goes exclusive
    Nature Cell Biology 2014 DOI
  • Vladimir Kirkin, Trond Lamark, Terje Johansen, Ivan Dikic :
    NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets
    Autophagy 2009

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    Publikasjoner utenom Cristin

    Svenning, S., Lamark, T., Krause, K., and Johansen, T:
    Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1.
    Autophagy. 2011, 7: 993-1010.

    Johansen, T and Lamark, T:
    Selective autophagy mediated by autophagic adapter proteins.
    Autophagy. 2011, 7: 279-296.

    Nezis, IP., Shravage, BV., Sagona, AP., Lamark, T., Bjørkøy, G., Johansen, T., Rusten, TE., Brech, A., Baehrecke, EH., and Stenmark, H:
    Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila oogenesis.
    J Cell Biol. 2010, 190: 523-31.

    Larsen, KB., Lamark, T., Øvervatn, A., Harneshaug, I., Johansen, T., Bjørkøy, G:
    A novel reporter cell system to estimate the speed of autophagy.
    Autophagy. 2010, 16: 784-93.

    Jain, A., Lamark, T., Sjøttem, E., Larsen, KB., Awuh, JA., Øvervatn, A., McMahon, M., Hayes, JD., Johansen, T:
    p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response-driven gene transcription.
    J Biol Chem. 2010, 285:22576-91.

    Filimonenko, M., Isakson, P., Sanderson, M., Finley, K., Jeong, H., Melia, T., Bartlett, BJ., Birkeland, HCG., Lamark, T., Brech, A, Stenmark, H., Krainc, D., Simonsen, A., and Yamamoto, A:
    The selective macroautophagic degradation of aggregated proteins requires the
    phosphatidylinositol 3-phosphate binding protein Alfy.
    Molecular Cell. 2010, 38:265-79.

    Clausen, TH., Lamark, T., Isakson, P., Finley, K., Larsen, KB., Brech, A., Øvervatn, A., Stenmark, H., Bjørkøy, G., Simonsen, A., and Johansen, T:
    p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.
    Autophagy. 2010, 6:330-44.

    Pankiv, S., Lamark, T., Bruun, JA., Øvervatn, A., Bjørkøy, G., and Johansen, T:
    Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to PML bodies.
    J Biol Chem. 2010, 285:5941-53.

    Pankiv, S., Alemu, EA., Brech, A., Bruun, JA., Lamark, T., Øvervatn, A., Bjørkøy, G., and Johansen, T:
    FYCO1 is a novel Rab7 effector binding to LC3 and PI3P to mediate microtubule plus-end-directed vesicle transport.
    J Cell Biol. 2010, 25:253-69.

    Lamark, T., and Johansen, T:
    Autophagy – links with the proteasome.
    Curr Opin Cell Biol. 2010, 22:192-8.

    Zheng, YT., Shahnazari, S., Brech, A., Lamark, T., Johansen, T., and Brumell, JH:
    The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway.
    J Immunol. 2009, 183:5909-16.

    Lamark, T., Kirkin, V., Dikic, I., and Johansen, T:
    NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets.
    Cell Cycle. 2009, 8:1986-90.

    Kirkin, V., Lamark, T., Johansen, T., and Dikic, I:
    NBR1 co-operates with p62 in selective autophagy of ubiquitinated targets.
    Autophagy. 2009, 5:732-33.

    Kirkin, V., Lamark, T., Sou, Y-S., Bjørkøy, G., Nunn, JL., Bruun, JA., Shvets, E., McEwan, DG., Clausen, TH., Bilusic, I., Theurillat, J-P., Øvervatn, A., Ishii, T., Elazar, Z., Komatsu, M., Dikic, I., and Johansen, T:
    A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
    Molecular Cell. 2009, 33:505-16.

    Bjørkøy, G., Lamark, T., Pankiv, S., Øvervatn, A., Brech, A., and Johansen, T:
    Monitoring autophagic degradation of p62/SQSTM1.
    Meth Enzymol. 2009, 452:181-97.

    Nezis, N. P., Lamark, T., Velentzas, AD., Rusten, TE., Bjørkøy, G., Johansen, T., Papassideri, IS., Stravopodis, DJ., Margaritis, LH., Stenmark, H., and Brech, A:
    Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy.
    Autophagy. 2009, 5:298-302.

    Pankiv, S., Clausen, TH., Lamark, T., Brech, A., Bruun, JA., Outzen, H., Øvervatn, A., Bjørkøy, G., and Johansen, T:
    p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.
    J Biol Chem. 2007, 282:24131-45.

    Bjørkøy, G., Lamark, T., and Johansen, T:
    p62/SQSTM1: A Missing Link between Protein Aggregates and the Autophagy Machinery.
    Autophagy. 2006, 2:138-39.

    Erdogan, E., Lamark, T., Stallings-Mann, M., Lee, J., Pellechia, M., Johansen, T., and Fields, AP:
    Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota.
    J Biol Chem. 2006, 281:28450-59.

    Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., and Johansen, T:
    p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.
    J Cell Biol. 2005, 171:603-14.

    Gruber, FX, Lamark, T., Anonli, A., Sovershaev, MA., Olsen, M., Gedde-Dahl, T., Hjort-Hansen, H., and Skogen, B:
    Selecting and deselecting imatinib-resistant clones: observations made by longitudinal, quantitative monitoring of mutated BCR-ABL.
    Leukemia. 2005, 19:2159-65.

    Lamark, T., Perander, M., Outzen, H., Kristiansen, K., Overvatn, A., Michaelsen, E., Bjørkøy, G., and Johansen, T:
    Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.
    J Biol Chem. 2003, 278:34568-81.

    Lamark. T., Ingebrigtsen, M., Bjørnstad, C., Melkko, T., Mollnes, TE., and Nielsen, EW:
    Expression of active human C1 inhibitor serpin domain in Escherichia coli.
    Protein Expr Purif. 2001, 22:349-58.

    Lamark. T., Røkenes, TP., McDougall, J., and Strøm, AR:
    The complex bet promoters of Escherichia coli: Regulation by oxygen (ArcA), choline (BetI) and osmotic stress.
    Journal of Bacteriology. 1996, 178: 1655-62.

    Røkenes, TP., Lamark. T., and Strøm, AR:
    DNA binding properties of the BetI repressor protein of Escherichia coli: The inducer choline stimulates BetI-DNA complex formation.
    Journal of Bacteriology. 1996, 178: 1663-70.

    Holmstrøm, K-O., Welin, B., Mandal, A., Kristiansdottir, I., Teeri, TH., Lamark, T., Strøm, AR., and Palva, ET:
    Production of the Escherichia coli betaine-aldehyde dehydrogenase, an enzyme required for the synthesis of the osmoprotectant glycine betaine, in transgenic plants.
    The Plant Journal. 1994, 6: 749-58.

    Lamark. T., Styrvold, OB., and Strøm, AR:
    Efflux of choline and glycine betaine from osmoregulating cells of Escherichia coli.
    FEMS Microbiological Letters. 1992, 96: 149-54.

    Lamark. T., Kaasen, I., Eshoo, MW., Falkenberg, P., McDougall, J., and Strøm, AR:
    DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli.
    Molecular Microbiology. 1991, 5:1049-64.


    Forskningsinteresser

    Autofagi
    Cellesignalering



    CV

    Utdanning
    Dr. scient. i Marin biokjemi ved Norges Fiskerihøgskole, UiTø (november 1995)

    Yrkespraksis
    1.10.1995-30.4.1998: Post. Doc. ved Norges Fiskerihøgskole, UiTø
    1.6.1998-31.12.2001: Vikariat som førsteamanuensis ved IFA, UiTø
    1.1.2002-31-12.2010: Forsker ved IMB, UiTø
    Fra 1.1.2011: Førsteamanuensis ved Molekylær Kreftforskningsgruppe, IMB, UiTø