Bilde av Johansen, Terje
Foto: Christian Halvorsen

Terje Johansen


Professor

Stillingsbeskrivelse

Professor i Biokjemi og Cellebiologi med mekanistisk grunnforskning innen selektiv autofagi som hovedforskningsfelt.

Forskningsgruppeleder for Autophagy Research Group (Autofagiforskningsgruppa).

Vitenskapelig leder for Proteomikk og Metabolomikk kjernefasiliteten (PRiME) ved UiT.


  • Yakubu Princely Abudu, Athanasios Kournoutis, Hanne Britt Brenne, Trond Lamark, Terje Johansen :
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
    Molecular Cell 2024 DOI
  • Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen m.fl.:
    TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
    Journal of Cell Biology 2023 ARKIV / DOI
  • Viola Nahse-Kumpf, Camilla Raiborg, Kia Wee Tan, Sissel Mørk, Maria Lyngaas Torgersen, Eva Wenzel m.fl.:
    ATPase activity of DFCP1 controls selective autophagy
    Nature Communications 2023 ARKIV / DOI
  • Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Stéphanie Kaeser-Pebernard, Trond Lamark, Joern Dengjel m.fl.:
    The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR
    Autophagy 2023 DOI
  • Hallvard Lauritz Olsvik, Terje Johansen :
    AlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy research
    PLoS Biology 2023 ARKIV / DOI
  • Jingyue Jia, Fulong Wang, Zambarlal Babanrao Bhujabal, Ryan Peters, Michal Mudd, Thabata Duque m.fl.:
    Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage
    Journal of Cell Biology 2022 ARKIV / DOI
  • Nikoline Lander Rasmussen, Athanasios Kournoutis, Trond Lamark, Terje Johansen :
    NBR1: The archetypal selective autophagy receptor
    Journal of Cell Biology 2022 ARKIV / DOI
  • Juncal Garcia Garcia, Anne Kristin McLaren Berge, Katrine Stange Overå, Kenneth Bowitz Larsen, Zambarlal Babanrao Bhujabal, Andreas Brech m.fl.:
    TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1
    The FEBS Journal 2022 ARKIV / DOI
  • Jingyue Jia, Fulong Wang, Zambarlal Babanrao Bhujabal, Ryan Peters, Michal Mudd, Thabata Duque m.fl.:
    Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage
    Autophagy 2022 ARKIV / DOI
  • Yahyah Aman, Tomas Schmauck-Medina, Malene Hansen, Richard I. Morimoto, Anna Katharina Simon, Ivana Bjedov m.fl.:
    Autophagy in healthy aging and disease
    Nature Aging 2021 DOI
  • Aurore Claude-Taupin, Jingyue Jia, Zambarlal Bhujabal, Meriem Garfa-Traore, Suresh Kumar, Gustavo Peixoto Duarte da Silva m.fl.:
    ATG9A protects the plasma membrane from programmed and incidental permeabilization.
    Nature Cell Biology 2021 ARKIV / DOI
  • Thaddaeus Mutugi Nthiga, Birendra Kumar Shrestha, Trond Lamark, Terje Johansen :
    The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor.
    Autophagy 2021 ARKIV / DOI
  • Yakubu Princely Abudu, Stephane Mouilleron, Sharon A Tooze, Trond Lamark, Terje Johansen :
    SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy
    Autophagy 2021 ARKIV / DOI
  • Thaddaeus Mutugi Nthiga, Birendra Kumar Shrestha, Jack-Ansgar Bruun, Kenneth Bowitz Larsen, Trond Lamark, Terje Johansen :
    Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy
    Journal of Cell Biology 2021 ARKIV / DOI
  • Trond Lamark, Terje Johansen :
    Mechanisms of Selective Autophagy
    Annual Review of Cell and Developmental Biology 2021 ARKIV / DOI
  • Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Khaled Abdellatif, Asghar Abdoli, Yakubu Princely Abudu m.fl.:
    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
    Autophagy 2021 DOI
  • Martina Wirth, Stephane Mouilleron, Wenxin Zhang, Eva Sjøttem, Yakubu Princely Abudu, Ashish Jain m.fl.:
    Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
    Journal of Molecular Biology (JMB) 2021 ARKIV / DOI
  • Yakubu Princely Abudu, Birendra Kumar Shrestha, Wenxin Zhang, Anthimi Palara, Hanne Britt Brenne, Kenneth Bowitz Larsen m.fl.:
    SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components
    Journal of Cell Biology 2021 ARKIV / DOI
  • Daniel J. Klionsky, Giulia Petroni, Ravi K Amaravadi, Eric H Baehrecke, Andrea Ballabio, Patricia Boya m.fl.:
    Autophagy in major human diseases
    EMBO Journal 2021 ARKIV / DOI
  • Caiyue Xu, Lu Wang, Parinaz Fozouni, Gry Evjen, Vemika Chandra, Jing Jiang m.fl.:
    SIRT1 is downregulated by autophagy in senescence and ageing
    Nature Cell Biology 2020 ARKIV / DOI
  • Lu Wang, Caiyue Xu, Terje Johansen, Shelley L. Berger, Zhixun Dou :
    SIRT1 - a new mammalian substrate of nuclear autophagy
    Autophagy 2020 ARKIV / DOI
  • Åsa birna Birgisdottir, Terje Johansen :
    Autophagy and endocytosis – interconnections and interdependencies
    Journal of Cell Science 2020 ARKIV / DOI
  • Thaddaeu Mutugi Nthiga, Birendra Kumar Shrestha, Trond Lamark, Terje Johansen :
    CALCOCO1 is a soluble reticulophagy receptor
    Autophagy 2020 ARKIV / DOI
  • Thaddaeus Mutugi Nthiga, Birendra Kumar Shrestha, Eva Sjøttem, Trond Lamark, Terje Johansen :
    CALCOCO1 acts with VAMP ‐associated proteins to mediate ER ‐phagy
    EMBO Journal 2020 ARKIV / DOI
  • Anne-Claire Jacomin, Stavroula Petridi, Marisa Di Monaco, Zambarlal Bhujabal, Ashish Jain, Nitha C. Mulakkal m.fl.:
    Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila
    Cell reports 2020 ARKIV / DOI
  • S. Petridi, A.-C. Jacomin, Zambarlal Bhujabal, Terje Johansen, Ioannis P Nezis :
    Exploring selective autophagy in Drosophila: Methods to identify Atg8-interacting proteins.
    Methods in Cell Biology 2020 DOI
  • Rocío de la Riva-Carrasco, Sebastián Perez-Pandolfo, Sofía Suárez Freire, Nuria M. Romero, Zambarlal Bhujabal, Terje Johansen m.fl.:
    The immunophilin Zonda controls regulated exocytosis in endocrine and exocrine tissues
    Traffic: The moving front of cell biology 2020 ARKIV / DOI
  • Anne-Claire Jacomin, Raksha Gohel, Zunoon Hussain, Agnes Varga, Tamas Maruzs, Mark Eddison m.fl.:
    Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila
    Life Science Alliance (LSA) 2020 ARKIV / DOI
  • Arjen J. Jakobi, Stefan T. Huber, Simon A. Mortensen, Sebastian Schultz, Anthimi Palara, Tanja Kuhm m.fl.:
    Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
    Nature Communications 2020 ARKIV / DOI
  • Yakubu Princely Abudu, Serhiy Pankiv, Benan John Mathai, Trond Lamark, Terje Johansen, Anne Simonsen :
    NIPSNAP1 and NIPSNAP2 act as “eat me” signals to allow sustained recruitment of autophagy receptors during mitophagy
    Autophagy 2019 DOI
  • Aurélien Schwob, Elodie Teruel, Louise Dubuisson, Florence Lormières, Pauline Verlhac, Yakubu Princely Abudu m.fl.:
    SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function
    Scientific Reports 05. november 2019 ARKIV / DOI
  • Petri Pölonen, Ashik Jawahar Deen, Hanna M. Leinonen, Henna-Kaisa Jyrkkänen, Suvi Kuosmanen, Mimmi Mononen m.fl.:
    Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
    Oncogene 2019 ARKIV / DOI
  • Nicolas Mercado, Thomas Colley, Jonathan R. Baker, Chaitanya Vuppussetty, Yuta Kono, Colin Clarke m.fl.:
    Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease
    FASEB BioAdvances 2019 ARKIV / DOI
  • Terje Johansen, Trond Lamark :
    Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors
    Journal of Molecular Biology (JMB) 2019 ARKIV / DOI
  • Yakubu Princely Abudu, Serhiy Pankiv, Benan John Mathai, Alf Håkon Lystad, Christian Bindesbøll, Hanne Britt Brenne m.fl.:
    NIPSNAP1 and NIPSNAP2 act as “eat-me signal” for mitophagy
    Developmental Cell 11. april 2019 ARKIV / DOI
  • Gry Hoem, Kenneth Bowitz Larsen, Aud Karin Øvervatn, Andreas Brech, Trond Lamark, Eva Sjøttem m.fl.:
    The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS
    Frontiers in Genetics 2019 ARKIV / DOI
  • Birendra Kumar Shrestha, Mads Skytte Rasmussen, Yakubu Princely Abudu, Jack-Ansgar Bruun, Kenneth Bowitz Larsen, Endalkachew Ashenafi Alemu m.fl.:
    NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1
    Journal of Biological Chemistry 2019 ARKIV / DOI
  • Stephanie R Kehl, Brandy-Lee A Soos, Bhaskar Saha, Seong Won Choi, Anthony W Herren, Terje Johansen m.fl.:
    TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform
    EMBO Reports 2019 ARKIV / DOI
  • Suresh Kumar, Yuexi Gu, Yakubu Princely Abudu, Jack-Ansgar Bruun, Ashish Jain, Farzin Farzam m.fl.:
    Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation
    Developmental Cell 28. april 2019 ARKIV / DOI
  • Mads Skytte Rasmussen, Åsa birna Birgisdottir, Terje Johansen :
    Use of Peptide Arrays for Identification and Characterization of LIR Motifs
    Methods in molecular biology 2019 ARKIV / DOI
  • Yuexi Gu, Yakubu Princely Abudu, Suresh Kumar, Bhawana Bissa, Seong Won Choi, Jingyue Jia m.fl.:
    Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs
    EMBO Journal 18. oktober 2019 ARKIV / DOI
  • Åsa birna Birgisdottir, Stephane Mouilleron, Zambarlal Bhujabal, Martina Wirth, Eva Sjøttem, Gry Evjen m.fl.:
    Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs
    Autophagy 2019 ARKIV / DOI
  • Athanasios Kournoutis, Terje Johansen :
    LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
    Journal of Cell Biology 2023 DOI
  • Terje Johansen :
    Selektiv autofagi: Kildesortering i cellene våre gir sunn aldring
    2022 DATA
  • Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen m.fl.:
    TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
    2021
  • Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen m.fl.:
    TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
    2021
  • Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen m.fl.:
    TNIP1 is degraded by selective autophagy upon proinflammatory signalling
    2021
  • Martina Wirth, Stephane Mouilleron, Wenxin Zhang, Eva Sjøttem, Yakubu Princely Abudu, Ashish Jain m.fl.:
    Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity (Journal of Molecular Biology (2021) 433(13), (S0022283621001881), (10.1016/j.jmb.2021.166987))
    Journal of Molecular Biology (JMB) 2021 DOI
  • Sebastian Andres Acuña Maldonado, Ida Sundvor Opstad, Luis Enrique Villegas Hernandez, Mona Nystad, Milton O Aguilera, Merete Storflor m.fl.:
    Fluorescence Nanoscopy Using Multiple Signal Classiflcation Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem
    2019
  • Andres Maldonado, Ida Sundvor Opstad, Luis Hernández, Mona Nystad, Milton Aguilera, Merete Storflor m.fl.:
    Fluorescence Nanoscopy Using Multiple Signal Classification Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem.
    2019

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    Forskningsinteresser

    Autofagi, celle signalering og genregulering med relevans for kreft,nevrodegenererende sykdommer og forsvar mot intracellulære infeksjoner.

    Undervisning

    Forelesninger på kurs i:

    MBI-2001 Biokjemi - 10 STP

    MBI-2012 Molekylær Cellebiology – Cellestruktur - 10 STP

    MBI-3004 The Biology of Cancer - 10 STP

    MBI-3012 Advanced methods in experimental biomedicine - 30 STP

    MBI-8007 Molecular and Clinical Aspects of Cancer - Block I - 10 STP


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