Karen Kristine Sørensen


Professor, forskningsgruppeleder

Stillingsbeskrivelse

Forskning og undervisning.

 

 

 


  • Ingelin Kyrrestad Karlstrøm, Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Ruomei Li, Karen Kristine Sørensen :
    Infection of liver sinusoidal endothelial cells with Muromegalovirus muridbeta1 involves binding to neuropilin-1 and is dynamin-dependent
    Frontiers in Cellular and Infection Microbiology 2023 ARKIV / DOI
  • Emma L. Shepherd, Ellie Northall, Pantelitsa Papakyriacou, Karolina Safranska, Karen Kristine Sørensen, Patricia F. Lalor :
    Decellularization of the Human Liver to Generate Native Extracellular Matrix for Use in Automated Functional Assays with Stellate Cells
    Methods in molecular biology 2023 DOI
  • Milton Boaheng Antewi, Gianina Aurica Dumitriu, Jaione Santamaria Simon, Javier Sanchez Romano, Ruomei Li, Bård Smedsrød m.fl.:
    Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIb, yet maintain a preserved fenestration in the Glmp gt/gt mouse model of slowly progressing liver fibrosis
    PLOS ONE 2023 ARKIV / DOI
  • Ruomei Li, Sabin Bhandari, Inigo Zubiavrre Martinez, Jack-Ansgar Bruun, Ilona Halva Urbarova, Bård Smedsrød m.fl.:
    Changes in the proteome and secretome of rat liver sinusoidal endothelial cells during early primary culture and effects of dexamethasone
    PLOS ONE 2022 ARKIV / DOI
  • Anett Kristin Larsen, Jaione Simon-Santamaria, kjetil helge Elvevold, Bo Gøran Ericzon, Kim Erlend Mortensen, Peter Anthony McCourt m.fl.:
    Autofluorescence in freshly isolated adult human liver sinusoidal cells
    European journal of histochemistry 2021 ARKIV / DOI
  • Sabin Bhandari, Anett Kristin Larsen, Peter Anthony McCourt, Bård Smedsrød, Karen Kristine Sørensen :
    The scavenger function of liver sinusoidal endothelial cells in health and disease
    Frontiers in Physiology 11. oktober 2021 ARKIV / DOI
  • Karen Kristine Sørensen, Bård Smedsrød :
    The Liver Sinusoidal Endothelial Cell: Basic Biology and Pathobiology
    John Wiley & Sons 2020
  • Cristina Ionica Øie, Deanna Wolfson, Tanji Yasunori, Gianina Dumitriu, Karen Kristine Sørensen, Peter Anthony McCourt m.fl.:
    Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses.
    Scientific Reports 2020 ARKIV / DOI
  • Javier Sanchez Romano, Karen Kristine Sørensen, Anett Kristin Larsen, Torill Mørk, Morten Tryland :
    Ocular Histopathological Findings in Semi-Domesticated Eurasian Tundra Reindeer (Rangifer tarandus tarandus) with Infectious Keratoconjunctivitis after Experimental Inoculation with Cervid Herpesvirus 2
    Viruses 2020 FULLTEKST / ARKIV / DOI
  • Sabin Bhandari, Ruomei Li, Jaione Simon-Santamaria, Peter Anthony McCourt, Steinar Daae Johansen, Bård Smedsrød m.fl.:
    Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages
    BMC Molecular and Cell Biology 2020 ARKIV / DOI
  • Bo Wold Nilsen, Jaione Simon-Santamaria, Ulf Thore Ørtengren, Einar Jensen, Jack-Ansgar Bruun, Vibeke Barman Michelsen m.fl.:
    Dose- and time-dependent effects of triethylene glycol dimethacrylate on the proteome of human THP-1 monocytes
    European Journal of Oral Sciences 2018 ARKIV / DOI
  • Anett Kristin Larsen, Ingebjørg Helena Nymo, Karen Kristine Sørensen, Marit Seppola, Rolf Rødven, María Pilar Jiménez de Bagüés m.fl.:
    Concomitant Temperature Stress and Immune Activation may Increase Mortality Despite Efficient Clearance of an Intracellular Bacterial Infection in Atlantic Cod
    Frontiers in Microbiology 2018 ARKIV / DOI
  • Morten Tryland, Javier Sanchez Romano, Nina Marcin, Ingebjørg Helena Nymo, Terje D. Josefsen, Karen Kristine Sørensen m.fl.:
    Cervid herpesvirus 2 and not Moraxella bovoculi caused keratoconjunctivitis in experimentally inoculated semi-domesticated Eurasian tundra reindeer
    Acta Veterinaria Scandinavica (AVS) 2017 ARKIV / DOI
  • Bo Wold Nilsen, Ulf Thore Ørtengren, Jaione Simon-Santamaria, Karen Kristine Sørensen, Vibeke Barman Michelsen :
    Methods and terminology used in cell-culture studies of low-dose effects of matrix constituents of polymer resin-based dental materials
    European Journal of Oral Sciences 2016 DOI
  • Karen Kristine Sørensen, Jaione Simon-Santamaria, Robert S. McCuskey, Bård Smedsrød :
    Liver sinusoidal endothelial cells
    Comprehensive Physiology 2015 DOI
  • Jaione Simon-Santamaria, Christine Hanssen Rinaldo, Piotr Kardas, Ruomei Li, Ivana Malovic, kjetil helge Elvevold m.fl.:
    Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta
    PLOS ONE 2014 ARKIV / DOI
  • Terje D. Josefsen, Torill Mørk, Karen Kristine Sørensen, Siri Kristine Knudsen, Hege J. Hasvold, Line Olsen :
    Funn ved obduksjon og undersøkelse av organer fra rein 1998-2011
    Norsk Veterinærtidsskrift 2014
  • Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Kim Erlend Mortensen, Ingelin Kyrrestad Karlstrøm, Eirik Abrahamsen Lænsman m.fl.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream.
    Journal of Hepatology 2023 DOI
  • Ingelin Kyrrestad Karlstrøm, Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Ruomei Li, Karen Kristine Sørensen :
    The dynamin-inhibitor dynasore blocks cytomegalovirus infection in primary mouse liver sinusoidal endothelial cells
    2023
  • Ingelin Kyrrestad Karlstrøm, Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Ruomei Li, Karen Kristine Sørensen :
    Dynamin-inhibitors dynasore and MitMAB block muromegalovirus muridbeta1 infection in liver sinusoidal endothelial cells.
    2023
  • Javier Sanchez Romano, Jaione Santamaria Simon, Peter Anthony Gerard Mccourt, Christopher Florian Holte, Bård Smedsrød, Antonia Sagona m.fl.:
    Rapid blood clearance of phage K1F-GFP is mediated by the liver and executed by Kupffer cells and liver sinusoidal endothelial cells in collaboration
    2023
  • Anett Kristin Larsen, Javier Sanchez Romano, Eirik Abrahamsen Lænsman, Anne Lotte Vada Hatlegjerde, Jaione Simon-Santamaria, Kim Erlend Mortensen m.fl.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream
    2022
  • Javier Sanchez Romano, Anett Kristin Larsen, Jaione Simon-Santamaria, Cristina Ionica Øie, Bård Smedsrød, Peter Anthony McCourt m.fl.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Javier Sanchez Romano, Anett Kristin Larsen, Jaione Simon-Santamaria, Cristina Ionica Øie, Bård Smedsrød, Peter Anthony McCourt m.fl.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Anett Kristin Larsen, Javier Sanchez Romano, Jaione Simon-Santamaria, Kim Erlend Mortensen, Bo Gøran Ericzon, Peter Anthony McCourt m.fl.:
    Role of liver sinusoidal endothelial cells in elimination of virus
    2022
  • Ingelin Kyrrestad, Javier Sanchez Romano, Anett Kristin Larsen, Ruomei Li, Jaione Simon-Santamaria, Kenneth Bowitz Larsen m.fl.:
    Effect of dynamin inhibitor dynasore on primary mouse liver sinusoidal endothelial cells (LSEC)
    2022
  • Anett Kristin Larsen, Jaione Simon-Santamaria, kjetil helge Elvevold, Bo G. Ericzon, Bård Smedsrød, Karen Kristine Sørensen :
    Autofluorescence in freshly isolated adult human liver sinusoidal cells
    2019
  • Sabin Bhandari, Ruomei Li, Ingelin Kyrrestad, Jack-Ansgar Bruun, Ilona Urbarova, Bård Smedsrød m.fl.:
    Effect of glucocorticoids on liver sinusoidal endothelial cells in vitro
    2019
  • Javier Sanchez Romano, Anett Kristin Larsen, kjetil helge Elvevold, Christopher Florian Holte, Jaione Simon-Santamaria, Hans H. Hirsch m.fl.:
    SECVIR - The role of scavenger endothelial cells in elimination of virus
    2019
  • Ingelin Kyrrestad, Ruomei Li, Sabin Bhandari, Jaione Simon-Santamaria, Bård Smedsrød, Karen Kristine Sørensen :
    A protocol for in vitro toxicity studies in liver sinusoidal endothelial cells
    2019
  • Karen Kristine Sørensen, Milton Boaheng Antwi, Gianina Dumitriu, Ruomei Li, Bård Smedsrød, Winnie Eskild :
    Scavenger function of liver sinusoidal endothelial cells in a transgenic mouse model of liver fibrosis is reduced
    2019
  • Javier Sanchez Romano, Morten Tryland, Ingebjørg Helena Nymo, Anett Kristin Larsen, Karen Kristine Sørensen :
    Infectious keratoconjunctivitis in reindeer - The role of the reindeer alphaherpesvirus
    UiT Norges arktiske universitet 2019
  • Javier Sanchez Romano, Karen Kristine Sørensen, Ingebjørg Helena Nymo, Torill Mørk, Morten Tryland :
    Histopathological study of eye tissues from semi-domesticated reindeer with infectious keratoconjunctivitis caused by cervid herpesvirus 2 in an experimental setting
    2018
  • Deanna Wolfson, Cristina Ionica Øie, Tanji Yasunori, Gianina Dumitriu, Peter Anthony McCourt, Karen Kristine Sørensen m.fl.:
    Uptake and Degradation of Bacteriophages by Liver Sinusoidal Endothelial Cells
    2018 ARKIV
  • Deanna Wolfson, Cristina Ionica Øie, Yasunori Tanji, Karen Kristine Sørensen, Peter Anthony McCourt, Bård Smedsrød m.fl.:
    Multimodal Microscopy to Study the Fate of Bacteriophages in Liver Sinusoidal Endothelial Cells
    2017
  • Hong Mao, Cristina Ionica Øie, Ruomei Li, Ana Oteiza, Karen Kristine Sørensen, Deanna Wolfson m.fl.:
    Disruption of rat liver sinusoidal endothelial cell morphology by oxidised low density lipoproteins
    2017
  • Hong Mao, Cristina Ionica Øie, Ruomei Li, Ana Oteiza, Karen Kristine Sørensen, Deanna Wolfson m.fl.:
    Using super-resolution microscopy to image disruption of liver sinusoidal endothelial cell morphology by oxidized low-density lipoproteins
    2017
  • Sabin Bhandari, Ruomei Li, Jaione Simon-Santamaria, Peter Anthony McCourt, Steinar Daae Johansen, Bård Smedsrød m.fl.:
    The liver sinusoidal endothelial cell – an endothelial cell with a macrophage-like identity
    2017
  • Ruomei Li, Jaione Simon-Santamaria, Sabin Bhandari, Jack-Ansgar Bruun, Ilona Urbarova, Bård Smedsrød m.fl.:
    Phenotypic changes in rat liver sinusoidal endothelial cells during early stages of in vitro culture
    2017
  • Javier Sanchez Romano, Morten Tryland, John A. Angelos, Torill Mørk, Ingebjørg Helena Nymo, Karen Kristine Sørensen :
    The pathogenic role of Moraxella bovoculi in infectious keratoconjunctivitis in semi-domesticated reindeer
    2017
  • Peter Anthony McCourt, Ana Oteiza, Melonie J. Storan, Brenda Williams, Chad K. Heazlewood, Karen Kristine Sørensen m.fl.:
    Identification of adult hemogenic sinusoidal endothelial cells in adult bone marrow.
    2016
  • Hong Mao, Cristina Ionica Øie, Ruomei Li, Ana Oteiza, Karen Kristine Sørensen, Deanna Wolfson m.fl.:
    Disruption of liver sinusoidal endothelial cell morphology by oxidized low–density lipoproteins
    2016
  • Bo Wold Nilsen, Ulf Thore Ørtengren, Jaione Simon-Santamaria, Karen Kristine Sørensen, Vibeke Barman Michelsen :
    Low-grade toxicity of matrix constituents of polymer resin based dental materials - A review of terminology and methods
    2016
  • Jaione Simon-Santamaria, Ruomei Li, Sabin Bhandari, Jack-Ansgar Bruun, Bård Smedsrød, Inigo Zubiavrre Martinez m.fl.:
    Secretome of the liver sinusoidal endothelial cell
    2016
  • Sabin Bhandari, Ruomei Li, Jaione Simon-Santamaria, Peter Anthony McCourt, Steinar Daae Johansen, Bård Smedsrød m.fl.:
    Next generation deep sequencing of rat liver sinusoidal endothelial cell and Kupffer cell transcriptomes suggests functional complementarity
    2016
  • Peter Anthony McCourt, Thomas Rolf Huser, Karen Kristine Sørensen, Cristina Ionica Øie, Viola Mönkemöller, Balpreet Singh Ahluwalia :
    Optical microscopy to reveal structural and functional properties of liver cells.
    2015
  • Javier Sanchez Romano, Morten Tryland, Ingebjørg Helena Nymo, Torill Mørk, Terje D. Josefsen, Karen Kristine Sørensen :
    Severe transmissible eye infection in reindeer: bacterium or virus?
    2015
  • Morten Tryland, Javier Sanchez Romano, Nina Marcin, P Kiær, OC Kjenstad, Torill Mørk m.fl.:
    Reindeer alphaherpesvirus (CvHV2) and not Moraxella bovoculi caused infectious keratoconjunctivitis experimentally in semi-domesticated reindeer (Rangifer tarandus tarandus)
    2015
  • Morten Tryland, Javier Sanchez Romano, Nina Marcin, Karen Kristine Sørensen, Ingebjørg Helena Nymo, Terje D. Josefsen m.fl.:
    The cause of infectious keratoconjunctivitis in semi-domesticated reindeer - an experimental approach
    2015
  • Jaione Simon-Santamaria, Christine H Rinaldo, Piotr Kardas, Ruomei Li, Ivana Malovic, Kjetil H. Elvevold m.fl.:
    Role of scavenger endothelial cells in polyomavirus JC and BK clearance
    2014

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    Forskningsinteresser

    • Liver sinusoidal endothelial cell (LSEC) biology
    • Scavenger function of LSEC in health and disease
    • Role of liver sinusoidal cells in the elimination of virus
    • Comparative and developmental aspects of scavenger endothelial cells

    Undervisning

    Underviser i cellebiologi, fysiologi, histologi og elektronmikroskopi i emner tilknyttet utdanningene i medisin, odontologi, bioingeniør, og bachelor/master/PhD i biomedisin. 

     



    Medlem i prosjekt


    CV

    Utdanning
    1989: Veterinærmedisinsk embetseksamen, Norges Veterinærhøgskole, Oslo
    1999: PhD i biologi, Universitetet i Tromsø

    Yrkespraksis
    1989-90: Avdelingsveterinær, Næringsmiddeltilsynet i Sortland og Øksnes
    1991-93: Klinisk stordyrpraksis, Leirfjord og Suldal
    1994-98: NFR-stipendiat, Avdeling for arktisk veterinærmedisin, NVH, Tromsø.
    1998-03: Forsker (patologi, mikrobiologi, laboratoriediagnostikk), Veterinærinstituttet Tromsø
    2003-06: Postdoktor (NFR), IMB, Avdeling for cellebiologi og histologi, UiT
    2005, 2007: Førsteamanuensis, vikariat, IMB, Avdeling for cellebiologi og histologi, UiT
    2007-10: Postdoktor/forsker, finansiert av Tromsø forskningsstiftelse og IMB, UiT
    2011-2013: Førsteamanuensis, Vaskulærbiologisk forskningsgruppe, IMB,UiT

    2013- : Professor, Vaskulærbiologisk forskningsgruppe, IMB, UiT. Forskningsgruppeleder fra 2020.