Bilde av Leiros, Ingar
Foto: INGAR LEIROS
Bilde av Leiros, Ingar
Institutt for kjemi ingar.leiros@uit.no +4777644064 +4795966895 Tromsø FPARK G 220

Ingar Leiros


Professor, Biomolekylær og strukturkjemi, Norstruct.


  • Marina Alexeeva, Marivi Nabong Moen, Xiang Ming Xu, Anette Rasmussen, Ingar Leiros, Finn Kirpekar m.fl.:
    Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification
    Frontiers in Immunology 22. desember 2021 ARKIV / DOI
  • Kristel Berg, Hege Lynum Pedersen, Ingar Leiros :
    Biochemical characterization of ferric uptake regulator (Fur) from Aliivibrio salmonicida. Mapping the DNA sequence specificity through binding studies and structural modelling
    Biometals 2020 ARKIV / DOI
  • Heidi Therese Hillier, Bjørn Altermark, Ingar Leiros :
    The crystal structure of the tetrameric DABA-aminotransferase EctB, a rate-limiting enzyme in the ectoine biosynthesis pathway.
    The FEBS Journal 2020 ARKIV / DOI
  • Kristin Grøsvik, Almaz Nigatu Tesfahun, Izaskun Muruzábal-Lecumberri, Gyri Teien Haugland, Ingar Leiros, Peter Ruoff m.fl.:
    The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside
    Frontiers in Microbiology 2020 ARKIV / DOI
  • Yvonne Piotrowski, Kristel Berg, David P. Klebl, Ingar Leiros, Atle Noralf Larsen :
    Characterization of an intertidal zone metagenome oligoribonuclease and the role of the intermolecular disulfide bond for homodimer formation and nuclease activity
    FEBS Open Bio 2019 ARKIV / DOI
  • Kristel Berg, Ingar Leiros, Adele Kim Williamson :
    Temperature adaptation of DNA ligases from psychrophilic organisms
    Extremophiles 2019 ARKIV / DOI
  • Marianne Slang Jensen, Lasse Fredriksen, Alasdair Mackenzie, Phillip Pope, Ingar Leiros, Piotr Chylenski m.fl.:
    Discovery and characterization of a thermostable two-domain GH6 endoglucanase from a compost metagenome
    PLOS ONE 2018 ARKIV / DOI
  • Gro Elin Kjæreng Bjerga, Øivind Larsen, Hasan ARSIN, Adele Kim Williamson, Antonio Garcia-Moyano, Ingar Leiros m.fl.:
    Mutational analysis of the pro-peptide of a marine intracellular subtilisin protease supports its role in inhibition
    Proteins: Structure, Function, and Bioinformatics 2018 ARKIV / DOI
  • Miriam Grgic, Adele Kim Williamson, Gro Elin Kjæreng Bjerga, Bjørn Altermark, Ingar Leiros :
    Biochemical characterization of ParI, an orphan C5-DNA methyltransferase from Psychrobacter arcticus 273-4
    Protein Expression and Purification 2018 ARKIV / DOI
  • Hege Lynum Pedersen, Kenneth Johnson, Colin McVey, Ingar Leiros, Elin Moe :
    Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA
    Acta Crystallographica Section D: Biological Crystallography 2015 ARKIV / DOI
  • Elin Moe, Netsanet Gizaw Assefa, Ingar Leiros, Kathrin Torseth, Arne O. Smalås, Nils Peder Willassen :
    Reduced Hydrophobicity of the Minor Groove Intercalation Loop is Critical for Efficient Catalysis by Cold Adapted Uracil-DNA N-Glycosylase from Atlantic Cod
    Journal of Thermodynamics & Catalysis 2015 DOI
  • Anders Kristiansen, Miriam Grgic, Bjørn Altermark, Ingar Leiros :
    Properties and distribution of a metallo-β-lactamase (ALI-1) from the fish pathogen Aliivibrio salmonicida LFI1238
    Journal of Antimicrobial Chemotherapy 2015 ARKIV / DOI
  • Hanna-Kirsti S. Leiros, Susann Skagseth, Kine Susann Waade Edvardsen, Marit Sjo Lorentzen, Gro Elin Kjæreng Bjerga, Ingar Leiros m.fl.:
    His224 alters the R2 drug binding site and Phe218 influences the catalytic efficiency of the metallo-β-lactamase VIM-7
    Antimicrobial Agents and Chemotherapy 2014 DOI
  • Elin Moe, D R Hall, Ingar Leiros, Vivi Talstad Monsen, Joanna Timmins, Sean McSweeney :
    Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans
    Acta Crystallographica Section D: Biological Crystallography 2012 DOI
  • Hanna-Kirsti S. Leiros, Anita-Elin Fedøy, Ingar Leiros, Ida Helene Steen :
    The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila support a new active site locking mechanism
    FEBS Open Bio 2012 ARKIV / DOI
  • Pardha Saradhi, Hanna-Kirsti S. Leiros, Rafi Ahmad, James Spencer, Ingar Leiros, Timothy R. Walsh m.fl.:
    Structural and Computational Investigations of VIM-7: Insights into the Substrate Specificity of VIM Metallo-beta-Lactamases
    Journal of Molecular Biology (JMB) 2011 DOI
  • Inger Lin Uttakleiv Ræder, Elin Moe, Nils Peder Willassen, Arne Oskar Smalås, Ingar Leiros :
    Structure of uracil-DNA N-glycosylase (UNG) from Vibrio cholerae: mapping temperature adaptation through structural and mutational analysis
    Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2010 DOI
  • In-Ja L. Byeon, Khanh Kim Dao, Jinwon Jung, Thomas Jeffrey Keen, Ingar Leiros, Stein Ove Doskeland m.fl.:
    Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR
    Journal of Biological Chemistry 2010 DOI
  • hege lynum Pedersen, Rafi Ahmad, EK Riise, Hanna-Kirsti S. Leiros, Stefan Hauglid, S Espelid m.fl.:
    Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida)
    Journal of Microbiology 2010 DOI
  • Ingeborg Knævelsrud, Marivi Moen, Kristin Grøsvik, Gyri Teien Haugland, Nils-Kåre Birkeland, Arne Klungland m.fl.:
    The Hyperthermophilic Euryarchaeon Archaeoglobus fulgidus Repairs Uracil by Single-Nucleotide Replacement
    Journal of Bacteriology 2010 DOI
  • I Knaevelsrud, I Knaevelsrud, G Slupphaug, Ingar Leiros, A Matsuda, P Ruoff m.fl.:
    Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1
    International Journal of Radiation Biology 2009 DOI
  • I. Knævelsrud, Geir Slupphaug, Ingar Leiros, A. Matsuda, Peter Ruoff, Svein Bjelland :
    Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1
    International Journal of Radiation Biology 2009 OMTALE
  • AB Robertson, A Klungland, T Rognes, Ingar Leiros :
    DNA Repair in Mammalian Cells
    Cellular and Molecular Life Sciences (CMLS) 2009 DOI
  • Susann Trondsen, Ingar Leiros, Bjørn Altermark :
    Expression and characterization of wood-degrading enzymes from a shipworm digestive system
    2020
  • Heidi Therese Hillier, Bjørn Altermark, Ingar Leiros :
    Enzymes in The Ectoine Biosynthesis Pathway
    2020
  • Susann Trondsen, Bjørn Altermark, Ingar Leiros :
    Shipworm-associated bacteria - A novel source of cold-adapted wood-degrading enzymes
    2019
  • Susann Trondsen, Ingar Leiros, Bjørn Altermark :
    Shipworm-associated bacteria - a novel source of cold-adapted wood-degrading enzymes
    2019
  • Heidi Therese Hillier, Bjørn Altermark, Ingar Leiros :
    Characterizing Enzymes in The Ectoine Biosynthesis Pathway
    2019
  • Heidi Therese Hillier, Bjørn Altermark, Ingar Leiros :
    Characterizing Enzymes in The Ectoine Biosynthesis Pathway
    2019
  • Heidi Therese Hillier, Bjørn Altermark, Ingar Leiros :
    Enzymes in the ectoine biosynthesis pathway
    2019
  • Heidi Therese Hillier, Ingar Leiros, Bjørn Altermark :
    Characterizing Enzymes in The Ectoine Biosynthesis Pathway
    2019
  • Susann Trondsen, Ingar Leiros, Inger Lin Uttakleiv Ræder, Seila Pandur, Bjørn Altermark :
    Tapping into the proteome of shipworm symbionts - a novel source of cold-adapted lignocellulases
    2019
  • Adele Kim Williamson, Erik Hjerde, Aili Sarre, Ingar Leiros, Kristel Berg, Hanna-Kirsti S. Leiros :
    Discovery and design of novel DNA ligases for biotechnology
    2018
  • Heidi Therese Hillier, Bjørn Altermark, Ingar Leiros :
    Ectoine: an osmolyte from the model organism Chromohalobacter salexigens
    2018
  • Heidi Therese Hillier, Bjørn Altermark, Ingar Leiros :
    Characterizing enzymes in the biosynthesis pathway of Ectoine
    2018
  • Man Kumari Gurung, Tor Olav Berg, Marie-Josée Haglund Halsør, Bjørn Altermark, Ingar Leiros, Ronny Helland m.fl.:
    Efficient production of sialic acids- Using enzymes for biomass conversion
    2017
  • Man Kumari Gurung, Tor Olav Berg, Marie-Josée Haglund Halsør, Bjørn Altermark, Ingar Leiros, Ronny Helland m.fl.:
    Efficient production of sialic acids- Using enzymes for biomass conversion
    2017
  • Øivind Larsen, Hasan Arsin, Runar Stokke, Antonio Garcia-Moyano, Pål Puntervoll, Ingar Leiros m.fl.:
    Discovery of proteases for bioconversion of marine biomass
    2017
  • Tor Olav Berg, Marie-Josée Haglund Halsør, Man Kumari Gurung, Bjørn Altermark, Ingar Leiros, Ulli Rothweiler m.fl.:
    From marine rest raw materials to sialic acids: Using enzymes for biomass conversion
    2016
  • Tor Olav Berg, Bjørn Altermark, Ingar Leiros, Ronny Helland, Inger Lin Uttakleiv Ræder :
    Production of sialic acids and derivatives by enzyme catalysis
    2016
  • Tor Olav Berg, Bjørn Altermark, Ingar Leiros, Ronny Helland, Inger Lin Uttakleiv Ræder :
    Biocatalytical production of sialic acids and derivatives
    2015
  • Elin Moe, Ingar Leiros, David Hall, Aili Sarre, Arne O. Smalås, Sean McSweeney m.fl.:
    Base Excision Repair (BER) in Deinococcus radiodurans
    2015
  • Susann Skagseth, Kine Susann Waade Edvardsen, Gro Elin Kjæreng Bjerga, marit sjo Lorentzen, Ingar Leiros, Ørjan Samulesen m.fl.:
    Site-directed mutagenesis of metallo-beta-lactamase VIM-7 from the opportunistic human pathogenic bacteria Pseudomonas aeruginosa
    2013
  • Man Kumari Gurung, Inger Lin Uttakleiv Ræder, Bjørn Altermark, Ingar Leiros, Mats Ökvist, Arne O. Smalås :
    Exploring sialic acid synthesizing enzymes from Aliivibrio salmonicida
    2012
  • Miriam Grgic, Gro Elin Kjæreng Bjerga, Bjørn Altermark, Ingar Leiros :
    C5-methyltransferase from cold-adapted organism
    2012
  • Inger Lin Uttakleiv Ræder, Man Kumari Gurung, Bjørn Altermark, Ingar Leiros, Mats Ökvist, Arne O. Smalås :
    Sialic acid biosynthesis in Aliivibrio salmonicida
    2011
  • Mats Ökvist, Inger Lin Uttakleiv Ræder, Ingar Leiros, Arne O. Smalås :
    Structure of sialic acid biosynthesis enzyme PtmG from Aliivibrio salmonicida
    2011
  • Man Kumari Gurung, Inger Lin Uttakleiv Ræder, Bjørn Altermark, Ingar Leiros, Mats Ökvist, Arne O. Smalås :
    Sialic acid biosynthesis in Aliivibrio salmonicida
    2011
  • Mats Ökvist, Inger Lin Uttakleiv Ræder, Ingar Leiros, Arne O. Smalås :
    Structure of Sialic Acid Biosynthesis Enzyme PtmG from Aliivibrio Salmonicida
    2011
  • Inger Lin Uttakleiv Ræder, Bjørn Altermark, Martina Hadrovic, Ingar Leiros, Arne O. Smalås :
    Sialic acid synthesis in Aliivibrio salmonicida
    2009

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    Forskningsinteresser

     

    Undervisning

    • Project leader: BioCat (2016-2024). BioCat is a national graduate school in biocatalysis, granted by The Norwegian Research Council. It is established to provide expertise and tools for research and research education within biocatalysis in Norway. The school is open to all PhD-students and their research groups within the field. Biocatalysis is important in many areas including  biomedicine, biotechnology,  microbiology, and (bio)nanoscience.  Additionally, biocatalysis is becomming increasingly important industrial processes and in various diagnostics-, gene- and biotechnologies, and is expected to be important in the transition of the society to a bio-based economy. Six Norwegian universities, 4 research institutes and the Industrial Biotechnology Network Norway, constitute the BioCat consortium. This collaboration represents a unification of many strong research groups, giving the students great access to both the expertise, facilities and training offered by the Norwegian biocatalysis research community.

    Medlem i forskningsgruppe