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  3. Elin Moe
Bilde av Moe, Elin
Foto: Ukjent
Bilde av Moe, Elin
Førsteamanuensis II, Biomolekylær og struktur kjemi Institutt for kjemi elin.moe@uit.no Tromsø

Elin Moe

  • Carlota J.F. Conceição, Elin Moe, Paulo A. Ribeiro, Maria Raposo :
    PARP1: A comprehensive review of its mechanisms, therapeutic implications and emerging cancer treatments
    Biochimica et Biophysica Acta. CR. Reviews on Cancer 2025 DOI
  • Bruno A. Salgueiro, Margarida Saramago, Mark D. Tully, Federico Issoglio, Sara T. N. Silva, Ana C. F. Paiva m.fl.:
    SARS-CoV2 Nsp1 is a metal-dependent DNA and RNA endonuclease
    Biometals 2024 ARKIV / DOI
  • Andreia Fernandes, Adele Kim Williamson, Pedro M. Matias, Elin Moe :
    Structure/function studies of the NAD+-dependent DNA ligase from the poly-extremophile Deinococcus radiodurans reveal importance of the BRCT domain for DNA binding
    Extremophiles 2023 ARKIV / DOI
  • Carlota J. F. Conceição, Elin Moe, Paulo A. Ribeiro, Maria Raposo :
    Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization
    Nanomaterials 2023 ARKIV / DOI
  • Carlota J.F. Conceição, Bruno A. Salgueiro, Paulo A. Ribeiro, Maria Raposo, Elin Moe :
    Advances in the expression and purification of human PARP1: A user-friendly protocol
    Protein Expression and Purification 2023 ARKIV / DOI
  • Filipe Rollo, Guilherme D. Martins, André G. Gouveia, Solenne Ithurbide, Pascale Servant, Célia V. Romão m.fl.:
    Insights into the role of three Endonuclease III enzymes for oxidative stress resistance in the extremely radiation resistant bacterium Deinococcus radiodurans
    Frontiers in Microbiology 2023 ARKIV / DOI
  • A. Fernandes, Yvonne Piotrowski, Adele Kim Williamson, K. Frade, Elin Moe :
    Studies of multifunctional DNA polymerase I from the extremely radiation resistant Deinococcus radiodurans: Recombinant expression, purification and characterization of the full-length protein and its large fragment
    Protein Expression and Purification 2021 DOI
  • Aili Sarre, Meike Stelter, Filipe Rollo, Salvatore De Bonis, Anna Seck, Cecilia Hognon m.fl.:
    The three Endonuclease III variants of Deinococcus radiodurans possess distinct and complementary DNA repair activities
    DNA Repair 2019 ARKIV / DOI
  • Joanna Timmins, Elin Moe :
    A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges
    Computational and Structural Biotechnology Journal 2016 ARKIV / DOI
  • Laila Niiranen, Kjersti Lian, Kenneth A Johnson, Elin Moe :
    Crystal structure of the DNA polymerase III β subunit (β-clamp) from the extremophile Deinococcus radiodurans
    BMC Structural Biology 2015 ARKIV / DOI
  • Kjersti Lian, Hanna-Kirsti S. Leiros, Elin Moe :
    MutT from the fish pathogen Aliivibrio salmonicida is a cold-active nucleotide-pool sanitization enzyme with unexpectedly high thermostability
    FEBS Open Bio 2015 ARKIV / DOI
  • Hege Lynum Pedersen, Kenneth Johnson, Colin McVey, Ingar Leiros, Elin Moe :
    Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA
    Acta Crystallographica Section D: Biological Crystallography 2015 ARKIV / DOI
  • Aili Sarre, Mats Ökvist, Tobias Klar, David Hall, Arne O. Smalås, Sean McSweeney m.fl.:
    Structural and functional characterization of two unusual endonuclease III enzymes from Deinococcus radiodurans
    Journal of Structural Biology 2015 DOI
  • Elin Moe, Netsanet Gizaw Assefa, Ingar Leiros, Kathrin Torseth, Arne O. Smalås, Nils Peder Willassen :
    Reduced Hydrophobicity of the Minor Groove Intercalation Loop is Critical for Efficient Catalysis by Cold Adapted Uracil-DNA N-Glycosylase from Atlantic Cod
    Journal of Thermodynamics & Catalysis 2015 DOI
  • Elin Moe, Murat Sezer, Peter Hildebrandt, Smilja Todorovic :
    Surface enhanced vibrational spectroscopic evidence for an alternative DNA-independent redox activation of endonuclease III
    Chemical Communications 2015 DOI
  • Aili Sarre, Mats Ökvist, Tobias Klar, Elin Moe, Joanna Timmins :
    Expression, purification and crystallization of two endonuclease III enzymes from Deinococcus radiodurans
    Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 01. desember 2014 DOI
  • Netsanet Gizaw Assefa, Laila Niiranen, Kenneth Johnson, Hanna-Kirsti S. Leiros, Arne O. Smalås, Nils Peder Willassen m.fl.:
    Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi)
    Acta Crystallographica Section D: Biological Crystallography 2014 ARKIV / DOI
  • Netsanet Gizaw Assefa, Laila Niiranen, Nils P Willassen, Arne O. Smalås, Elin Moe :
    Thermal unfolding studies of cold adapted uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). A comparative study with human UNG
    Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology 2012 DOI
  • Elin Moe, D R Hall, Ingar Leiros, Vivi Talstad Monsen, Joanna Timmins, Sean McSweeney :
    Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans
    Acta Crystallographica Section D: Biological Crystallography 2012 DOI
  • Inger Lin Uttakleiv Ræder, Elin Moe, Nils Peder Willassen, Arne Oskar Smalås, Ingar Leiros :
    Structure of uracil-DNA N-glycosylase (UNG) from Vibrio cholerae: mapping temperature adaptation through structural and mutational analysis
    Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2010 DOI
  • Bjørn Altermark, Ronny Helland, Elin Moe, Nils Peder Willassen, Arne Oskar Smalås :
    Structural adaptation of endonuclease I from the cold-adapted and halophilic bacterium Vibrio salmonicida
    Acta Crystallographica Section D: Biological Crystallography 2008 DOI
  • Inger Lin Uttakleiv Ræder, Ingar Leiros, Nils Peder Willassen, Arne Oskar Smalås, Elin Moe :
    Uracil-DNA N-glycosylase (UNG) from the marine, psychrophilic bacterium Vibrio salmonicida shows cold adapted features A comparative analysis to Vibrio cholerae uracil-DNA N-glycosylase
    Enzyme and Microbial Technology 2008 DOI
  • Bjørn Altermark, Ronny Helland, Elin Moe, Nils Peder Willassen, Arne Oskar Smalås :
    Environmental adaptation of endonuclease I from Vibrio salmonicida
    Acta Crystallographica Section D: Biological Crystallography 2008
  • Bjørn Altermark, Laila Mirja Niiranen, Nils Peder Willassen, Arne Oskar Smalås, Elin Moe :
    Comparative studies of endonuclease I from cold-adapted Vibrio salmonicida and mesophilic Vibrio cholerae
    The FEBS Journal 2007 DOI
  • Bjørn Altermark, Steinar Thorvaldsen, Elin Moe, Arne Oskar Smalås, Nils Peder Willassen :
    Sequence comparison and environmental adaptation of a bacterial endonuclease
    Computational biology and chemistry 2007 DOI
  • Ingar Leiros, Marivi P. Nabong, Kristin Grøsvik, Jeanette Ringvoll, GT Haugland, Lene Uldal m.fl.:
    Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA
    EMBO Journal 2007
  • Hanna-Kirsti S. Leiros, AL Pey, M Innselset, Marte Innselset, Elin Moe, Ingar Leiros m.fl.:
    Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability
    Journal of Biological Chemistry 2007 DOI
  • Ingar Leiros, MP Nabong, Marivi Nabong, K Grosvik, Kristin Grøsvik, J Ringvoll m.fl.:
    Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA
    EMBO Journal 2007 DOI
  • Marit Sjo Lorentzen, Elin Moe, HM Jouve, Nils Peder Willassen :
    Cold adapted features of Vibrio salmonicida catalase: characterisation and comparison to the mesophilic counterpart from Proteus mirabilis
    Extremophiles 2006
  • RJ Dennis, E. Micossi, J.J. McCarthy, Elin Moe, E. Gordon, S. Kozielski-Stuhrmann m.fl.:
    Structure of the manganese superoxide dismutase from Deinococcus radiodurans in two crystal forms
    Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2006
  • Elin Moe, Ingar Leiros, Arne Oskar Smalås, Sean McSweeney :
    The crystal structure of mismatch-specific uracil-DNA glycosylase (MUG) from Deinococcus radiodurans reveals a novel catalytic residue and broad substrate specificity
    Journal of Biological Chemistry 06. januar 2006
  • Atle Noralf Larsen, Elin Moe, Ronny Helland, Dag Rune Gjellesvik, Nils Peder Willassen :
    Characterization of a recombinantly expressed proteinase K-like enzyme from a psychrotrophic Serratia sp
    The FEBS Journal 2006
  • Magne Olufsen, Arne Oskar Smalås, Elin Moe, Bjørn Olav Brandsdal :
    Increased flexibility as a strategy for cold adaptation - A comparative molecular dynamics study of cold- and warm-active uracil DNA glycosylase
    Journal of Biological Chemistry 2005
  • Concetta De Santi, Ragnhild Whitaker, Elin Moe, Fredrik Almqvist, Nils Peder Willassen, Peik Haugen :
    MicroMBT: Microbial communities and moving bed technology as tools for conversion of marine biomass
    2017
  • Marcin Miroslaw Pierechod, Concetta De Santi, Ragnhild Whitaker, Elin Moe, Henrik Antti, Fredrik Almqvist m.fl.:
    MicroMBT: Microbial communities and moving bed technology as tools for conversion of Marine Biomass
    2017
  • Concetta De Santi, Ragnhild Dragøy Whitaker, Elin Moe, Fredrik Almqvist, Nils Peder Willassen, Peik Haugen :
    MicroMBT: Microbial communities and moving bed technology as tools for conversion of marine biomass
    2016
  • Elin Moe, Ingar Leiros, David Hall, Aili Sarre, Arne O. Smalås, Sean McSweeney m.fl.:
    Base Excision Repair (BER) in Deinococcus radiodurans
    2015
  • Davi de Miranda Fonseca, Cecilie Christensen Baar, Netsanet Gizaw Assefa, Elin Moe, Nina-Beate Liabakk, Hanna-Kirsti S. Leiros m.fl.:
    Thermo-sensitive human UNG-mutants
    2013
  • Davi de Miranda Fonseca, Elin Moe, Nina-Beate Liabakk, Cecilie Christensen Baar, Frank Skorpen, Hans Einar Krokan :
    Thermo-sensitive mutants of UNG protein studied by structural experiments – Perspectives
    2012
  • Hege Lynum Pedersen, Laila Niiranen, Kjersti Lian, Aili Sarre, Joanna Timmins, Sean McSweeney m.fl.:
    Protein interaction studies of BER proteins from the extreme radiation resistant bacterium Deinococcus radiodurans
    2010
  • Laila Niiranen, Hege Lynum Pedersen, Kjersti Lien, Aili Sarre, Joanna Timmins, S McSweeney m.fl.:
    Identification of novel interaction partners for DNA glycosylases in the extreme radiation resistant bacterium Deinococcus radiodurans
    2009
  • Netsanet Gizaw Assefa, Elin Moe, Arne Oskar Smalås, Nils Peder Willassen :
    Thermodynamic characterization of uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua)
    The FEBS Journal 2008
  • Elin Moe, Ingar Leiros, David Richard Hall, Arne Oskar Smalås, Sean McSweeney :
    Structure/function studies of Base Excision Repair (BER) enzymes from the extreme radiation resistant bacterium Deinococcus radiodurans
    2008
  • Hanna-Kirsti S. Leiros, Angel L. Pey, M Innselset, Elin Moe, Ingar Leiros, Ida Helene Steen m.fl.:
    Crystal Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H reveals a monomeric cold active enzyme with local flexibility around the active site and high overall stability
    2008
  • Ingar Leiros, Marivi P. Nabong, GT Haugland, Jeanette Ringvoll, K Grøsvik, K Grøsvik m.fl.:
    Excision of 1-methyladenine and 3-methylcytosine from DNA by AfAlkA of Archaeoglobus fulgidus
    2006
  • Bjørn Altermark, Ronny Helland, Laila Mirja Niiranen, Elin Moe, Bjørn Olav Brandsdal, Arne Oskar Smalås m.fl.:
    Optimum enzymatic activity of endonuclease I from Vibrio salmonicida and Vibrio cholerae correlateswith the bacterial growth habitat
    2006
  • Inger Lin Uttakleiv Ræder, Ingar Leiros, Nils Peder Willassen, Arne Oskar Smalås, Elin Moe :
    Uracil-DNA N-glycosylase (UNG) from the marine psychrophilic bacterium Vibrio salmonicida shows cold adapted features
    2006
  • Elin Moe, Joanna Timmins, David Richard Hall, Ingar Leiros, Sean McSweeney :
    Structure-function studies of DNA repair proteins from Deinococcus radiodurans
    2006
  • Ingar Leiros, Marivi P. Nabong, Gyri Teien Haugland, Jeanette Ringvoll, Kristin Grøsvik, Elin Moe m.fl.:
    Excision of 1-methyladenine and 3-methylcytosine from DNA by AfAlkA of Archaeoglobus fulgidus.
    2006
  • Elin Moe, Ingar Leiros, Arne Oskar Smalås, Sean McSweeney :
    Crystallisation and structure determination of a mismatch specific DNA glycosylase (MUG) from Deinococcus radiodurans
    2005

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    Forskningsinteresser

    Deinococcus radiodurans is a pink/orange pigmented bacterium which was first identified I 1956 in canned meat sterilised by ionising radiation. D. radiodurans exhibits an outstanding resistance to ionising radiation and desiccation and tolerates radiation doses up to 5,000 Grays (Gy) without loss of viability. Most other organisms cannot survive doses above 50 Gy. I am studying the role of the Base Excision Repair (BER) pathway for the extreme radation resistance of this organism, and use an integrated structural biology approach for this purpose.

    Undervisning

    Kje-3603 Protein production technology