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Institutt for kjemi tca003@post.uit.no 77645994 Tromsø FPARK G 113.1

Carlsen, Trine Josefine Warg


Arbeidstittel

Avdelingsingeniør

Stillingsbeskrivelse


  • Lund, Bjarte Aarmo; Thomassen, Ane Molden; Carlsen, Trine Josefine Warg; Leiros, Hanna-Kirsti Schrøder. Biochemical and biophysical characterization of the OXA-48-like carbapenemase OXA-436. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2021; Volum 77 (9). ISSN 1744-3091.s 312 - 318.s doi: 10.1107/S2053230X21008645.
  • Samuelsen, Ørjan; Åstrand, Ove Alexander Høgmoen; Frøhlich, Christopher; Heikal, Adam; Skagseth, Susann; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.; Bayer, Annette; Schnaars, Christian; Kildahl-Andersen, Geir; Lauksund, Silje; Finke, Sarah; Huber, Sandra; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Økstad, Ole Andreas; Rongved, Pål. ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo. (data) Antimicrobial Agents and Chemotherapy 2020; Volum 64 (6). ISSN 0066-4804.s doi: 10.1128/AAC.02415-19.
  • Lund, Bjarte Aarmo; Thomassen, Ane Molden; Nesheim, Birgit Helene Berg; Carlsen, Trine Josefine Olsen; Isaksson, Johan; Christopeit, Tony; Leiros, Hanna-Kirsti S.. The biological assembly of OXA‐48 reveals a dimer interface with high charge complementarity and very high affinity. The FEBS Journal 2018; Volum 285 (22). ISSN 1742-464X.s 4214 - 4228.s doi: 10.1111/febs.14643.
  • Lund, Bjarte Aarmo; Thomassen, Ane Molden; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.. Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2017; Volum 73 (10). ISSN 1744-3091.s 579 - 587.s doi: 10.1107/S2053230X17013838.
  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Spencer, James; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Role of residues W228 and Y233 in the structure and activity of metallo-β-lactamase GIM-1. Antimicrobial Agents and Chemotherapy 2016; Volum 60 (2). ISSN 0066-4804.s 990 - 1002.s doi: 10.1128/AAC.02017-15.
  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Helland, Ronny; Leiros, Hanna-Kirsti S.. Discovery of novel inhibitor scaffolds against the metallo-β-lactamase VIM-2 by surface plasmon resonance (SPR) based fragment screening. Journal of Medicinal Chemistry 2015; Volum 58 (21). ISSN 0022-2623.s 8671 - 8682.s doi: 10.1021/acs.jmedchem.5b01289.
  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Albert, Anastasia; Skagseth, Susann; Leiros, Hanna-Kirsti S.. Discovery of a Novel Covalent Inhibitor of the Metallo-beta-lactamase NDM-1. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.
  • Nesheim, Birgit Berg; Carlsen, Trine Josefine Olsen; Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.. Residue profiling of antibiotic resistant OXA-beta-lactamases through mutagenesis, enzyme kinetics and 3D structures. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.
  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Christopeit, Tony; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. 51st Norwegian Biochemical Society Contact Meeting, Svalbard 2015-02-09 - 2015-02-13 2015.
  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. Annual BioStruct Conference, The National graduate school in structural biology 2015-09-27 - 2015-09-30 2015.
  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. BioStruct Open Day 2015-03-20 - 2015-03-20 2015.
  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Using fragment screening to identify novel starting points for potent inhibitors of metallo-beta-lactamase VIM-2. Fragments 2015: Fifth RSC-BMCS Fragment-based Drug Discovery meeting 2015-03-22 - 2015-03-22 2015.
  • Christopeit, Tony; Lund, Bjarte Aarmo; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Using Fragment Screening to Identify Novel Starting Points for Potent Carbapenemase Inhibitors. Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) 2015-09-17 - 2015-09-21 2015.
  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue W228 and Y233 in the metallo-beta-lactamase GIM-1. The Norwegian Biochemical Society (NBS) Contact Meeting 2014 2014-01-23 - 2014-01-26 2014.
  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue Trp228 and Tyr233 in the metallo-beta-lactamase GIM-1. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.
  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Characterization of substrate and inhibitor binding to different beta-lactamases using Surface Plasmon Resonance based biosensors. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.
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    FPARK G 113.1