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Institutt for medisinsk biologi gunhild.malandsmo@uit.no

Gunhild Mari Mælandsmo


Professor II


  • Caroline Elisabeth Nunes-Xavier, Maite Emaldi, Janire Mingo, Tove Ragnhild Øyjord, Gunhild Mari Mælandsmo, Øystein Fodstad m.fl.:
    The expression pattern of pyruvate dehydrogenase kinases predicts prognosis and correlates with immune exhaustion in clear cell renal cell carcinoma
    Scientific Reports 2023 ARKIV / DOI
  • Solveig Pettersen, Geir Frode Øy, Eivind Valen Egeland, Siri Juell, Olav Engebråten, Gunhild Mari Mælandsmo m.fl.:
    Breast cancer patient-derived explant cultures recapitulate in vivo drug responses
    Frontiers in Oncology 2023 ARKIV / DOI
  • Salim Ghannoum, Damiano Fantini, Muhammad Zahoor, Veronika Reiterer, Santosh Phuyal, Waldir Leoncio Netto m.fl.:
    A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression
    PLoS Computational Biology 2023 ARKIV / DOI
  • Erik Knutsen, Saikat Das Sajib, Tonje Fiskaa, James Bradley Lorens, Thorarinn Gudjonsson, Gunhild Mari Mælandsmo m.fl.:
    Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes
    Frontiers in Oncology 2023 ARKIV / DOI
  • Lisa Gregusson Svartdal, Mads Haugen, Vesa Hongisto, Miriam Ragle Aure, Suvi-Katri Leivonen, Vessela N. Kristensen m.fl.:
    High-throughput screen in vitro identifies dasatinib as a candidate for combinatorial treatment with HER2-targeting drugs in breast cancer
    PLOS ONE 2023 ARKIV / DOI
  • Mads Haugen, Hedda von der Lippe Gythfeldt, Eivind Valen Egeland, Lisa Svartdal Normann, Abhilash D. Pandya, Lise-Lotte Vedin m.fl.:
    Liver X receptors induce antiproliferative effects in basal-like breast cancer
    Molecular Oncology 2023 ARKIV / DOI
  • Gisella Figlioli, Amandine Billaud, Thomas U. Ahearn, Natalia N. Antonenkova, Heiko Becher, Matthias W. Beckmann m.fl.:
    FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women
    European Journal of Human Genetics 2023 DOI
  • Vigdis Nygaard, Anne Hansen Ree, Vegar Johansen Dagenborg, Anne-Lise Børresen-Dale, Bjørn von Gohren Edwin, Åsmund Avdem Fretland m.fl.:
    A PRRX1 Signature Identifies TIM-3 and VISTA as Potential Immune Checkpoint Targets in a Subgroup of Microsatellite Stable Colorectal Cancer Liver Metastases
    Cancer Research Communications 2023 ARKIV / DOI
  • Caroline Elisabeth Nunes-Xavier, Janire Mingo, Maite Emaldi, Karine Flem-Karlsen, Gunhild Mari Mælandsmo, Øystein Fodstad m.fl.:
    Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer
    Frontiers in Oncology 2022 DOI
  • Marta Sølvi Nyakas, Karianne Giller Fleten, Mads Haugland Haugen, Nikolai Engedal, Christina Sveen, Inger Nina Farstad m.fl.:
    AXL inhibition improves BRAF-targeted treatment in melanoma
    Scientific Reports 2022 ARKIV / DOI
  • Marta Tellez Gabriel, Xavier Tekpli, Trine M. Reine, Beate Hegge, Stephanie Rose Nielsen, Meng Chen m.fl.:
    Serglycin is Involved in TGF-β induced epithelial-mesenchymal transition and is highly expressed by immune cells in breast cancer tissue
    Frontiers in Oncology 14. april 2022 ARKIV / DOI
  • Elisa Fiorito, Patrycja Maria Szybowska, Ellen Margrethe Haugsten, Michal Janusz Kostas, Geir Frode Øy, Antoni Wiedlocha m.fl.:
    Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma
    British Journal of Cancer 2022 ARKIV / DOI
  • Anne Hansen Ree, Gunhild Mari Mælandsmo, Kjersti Flatmark, Hege Elisabeth Giercksky Russnes, Monica Gomez Casteneda, Eline Aas :
    Cost-effectiveness of molecularly matched off-label therapies for end-stage cancer – the MetAction precision medicine study
    Acta Oncologica 2022 ARKIV / DOI
  • Caroline Elisabeth Nunes-Xavier, Maite Emaldi, Ingrid Jenny Guldvik, Håkon Ramberg, Kristin Austlid Tasken, Gunhild Mari Mælandsmo m.fl.:
    Correlation of expression of Major Vault Protein with androgen receptor and immune checkpoint protein B7-H3, and with poor prognosis in prostate cancer
    Pathology, Research and Practice 2022 ARKIV / DOI
  • Sunniva Bjørklund, Miriam Ragle Aure, Jari Häkkinen, Johan Vallon-Christersson, Surendra Kumar, Katrine Bull Evensen m.fl.:
    Subtype and cell type specific expression of lncRNAs provide insight into breast cancer
    Communications Biology 2022 ARKIV / DOI
  • Lisa Svartdal Normann, Mads Haugland Haugen, Miriam Ragle Aure, Vessela N. Kristensen, Gunhild Mari Mælandsmo, Kristine Kleivi Sahlberg :
    miR-101-5p Acts as a Tumor Suppressor in HER2-Positive Breast Cancer Cells and Improves Targeted Therapy
    Breast Cancer: Targets and Therapy 2022 ARKIV / DOI
  • Margherita Ambrosini, Marzia Del Re, Paolo Manca, Andrew Hendifar, Alexander Drilon, Guilherme Harada m.fl.:
    ALK Inhibitors in Patients with ALK Fusion-Positive GI Cancers: An International Data Set and a Molecular Case Series
    JCO Precision Oncology (JCO PO) 2022 ARKIV / DOI
  • Sigurdur Karvelsson, Arnar Sigurdsson, Kotryna Seip, Maria Tunset Grinde, Qiong Wang, Freyr Johanssson m.fl.:
    EMT-derived alterations in glutamine metabolism sensitize mesenchymal breast cells to mTOR inhibition
    Molecular Cancer Research 05. juni 2021 ARKIV / DOI
  • Vegar Johansen Dagenborg, Serena Marshall, Krzysztof Grzyb, Åsmund Avdem Fretland, Marius Lund-Iversen, Gunhild Mari Mælandsmo m.fl.:
    Low Concordance Between T-Cell Densities in Matched Primary Tumors and Liver Metastases in Microsatellite Stable Colorectal Cancer
    Frontiers in Oncology 2021 ARKIV / DOI
  • Henrik Aasrum Svendsen, Torstein Ragnar Meling, Vigdis Nygaard, Stein Waagene, Hege Elisabeth Giercksky Russnes, Siri Juell m.fl.:
    Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site-specific metastasis patterns reflecting their clinical origin
    Cancer Medicine 2021 ARKIV / DOI
  • Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Vigdis Sørensen, Geir Frode Øy, Skjalg Bruheim, Ellen Margrethe Haugsten m.fl.:
    Fibroblast growth factor 2 conjugated with monomethyl auristatin E inhibits tumor growth in a mouse model
    Biomacromolecules 2021 ARKIV / DOI
  • Lisa Gregusson Svartdal Normann, Miriam Ragle Aure, Suvi-Katri Leivonen, Mads Haugland Haugen, Vesa Hongisto, Vessela N. Kristensen m.fl.:
    MicroRNA in combination with HER2-targeting drugs reduces breast cancer cell viability in vitro
    Scientific Reports 2021 ARKIV / DOI
  • Tripti Tamhane, Robin W. Njenga, Roberta E. Burden, Heiko Büth, Gunhild Mari Mælandsmo, Mads Haugland Haugen m.fl.:
    Trafficking of full-length and N-terminally truncated cathepsin B in human colorectal carcinoma cells
    Applied Sciences 2021 DOI
  • Inga Hansine Rye, Kanutte Huse, Sarah Elisabet Josefsson, Wanja Kildal, Håvard Emil Greger Danielsen, Ellen Schlichting m.fl.:
    Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression
    Molecular Oncology 2021 ARKIV / DOI
  • Caroline Elisabeth Nunes-Xavier, Wanja Kildal, Andreas Kleppe, Håvard Emil Greger Danielsen, Håkon Wæhre, Roberto Llarena m.fl.:
    Immune checkpoint B7-H3 protein expression is associated with poor outcome and androgen receptor status in prostate cancer
    The Prostate 2021 ARKIV / DOI
  • Mads Haugland Haugen, Ole Christian Lingjærde, Ingrid Hedenfalk, Øystein Garred, Elin Borgen, Niklas Loman m.fl.:
    Protein signature predicts response to neoadjuvant treatment with chemotherapy and bevacizumab in HER2-negative breast cancers
    JCO Precision Oncology (JCO PO) 2021 ARKIV / DATA / DOI
  • Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn m.fl.:
    Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
    Nature Genetics 2021 DOI
  • Remya Valsalakumari, Sunil Kumar Yadava, Marzena Szwed, Abhilash D. Pandya, Gunhild Mari Mælandsmo, Maria Lyngaas Torgersen m.fl.:
    Mechanism of cellular uptake and cytotoxicity of paclitaxel loaded lipid nanocapsules in breast cancer cells.
    International Journal of Pharmaceutics 2021 ARKIV / DOI
  • Anna Barkovskaya, Craig Goodwin, Kotryna Seip, Bylgja Hilmarsdòttir, Solveig Pettersen, Clint Stalnecker m.fl.:
    Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen
    Molecular Oncology 2021 ARKIV / DOI
  • Abhilash D. Pandya, Tore Geir Iversen, Siver Andreas Moestue, Maria Tunset Grinde, Ýrr Asbjørg Mørch, Sofie Snipstad m.fl.:
    Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft
    Nanomaterials 2021 ARKIV / DOI
  • Sigurdur Karvelsson, Qiong Wang, Bylgja Hilmarsdòttir, Arnar Sigurdsson, Siver Andreas Moestue, Gunhild Mari Mælandsmo m.fl.:
    Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer
    npj Systems Biology and Applications 2021 ARKIV / DOI
  • Karianne Giller Fleten, Jacobus Johannes Eksteen, Brynjar Mauseth, Ketil André Camilio, Terje Vasskog, Baldur Sveinbjørnsson m.fl.:
    Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer
    Scientific Reports 2021 ARKIV / DOI
  • Vegar Johansen Dagenborg, Serena Elizabeth Marshall, Krzysztof Grzyb, Åsmund Avdem Fretland, Marius Lund-Iversen, Gunhild Mari Mælandsmo m.fl.:
    Low concordance between T-cell densities in matched primary tumors and liver metastases in microsatellite stable colorectal cancer
    Frontiers in Oncology 2020
  • Maria Lyngaas Torgersen, Peter J. Judge, Juan F. Bada Juarez, Abhilash D. Pandya, Markus Fusser, Charlie W. Davies m.fl.:
    Physicochemical characterization, toxicity and in vivo biodistribution studies of a discoidal, lipid-based drug delivery vehicle: Lipodisq nanoparticles containing doxorubicin
    Journal of Biomedical Nanotechnology 2020 ARKIV / DOI
  • Anne Hansen Ree, Vigdis Nygaard, Kjetil Boye Pedersen, Daniel Heinrich, Svein Dueland, Inger Riise Bergheim m.fl.:
    Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer?the MetAction study
    Acta Oncologica 2020 ARKIV / DOI
  • Ann Rita Halvorsen, Mads Haugland Haugen, Åsa Kristina Øjlert, Marius Lund-Iversen, Lars Hilmar Jørgensen, Steinar Solberg m.fl.:
    Protein kinase C isozymes associated with relapse free survival in non-small cell lung cancer patients
    Frontiers in Oncology 25. november 2020 ARKIV / DOI
  • Sophie Sarah Steinhaeuser, Erika Morera, Zuzana Budkova, Alexander Schepsky, Qiong Wang, Ottar Rolfsson m.fl.:
    ECM1 secreted by HER2-overexpressing breast cancer cells promotes formation of a vascular niche accelerating cancer cell migration and invasion
    Laboratory Investigation 2020 DOI
  • Pierre Dillard, Hakan Köksal, Solrun Melkorka Maggadottir, Anna Katharina Winge-Main, Sylvie Mireille Pollmann, Mathilde Ménard m.fl.:
    Targeting Telomerase with an HLA Class II-Restricted TCR for Cancer Immunotherapy
    Molecular Therapy 2020 DOI
  • Abhilash D. Pandya, Anders Øverbye, Priyanka Saharia, Vivek S. Gaware, Håkon Høgset, Már Masson m.fl.:
    Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer
    Biomacromolecules 2020 ARKIV / DOI
  • Karine Flem-Karlsen, Marta Sølvi Nyakas, Inger Nina Farstad, Erin McFadden, Patrik Vernhoff, Kari Dolven Jacobsen m.fl.:
    Soluble AXL as a marker of disease progression and survival in melanoma
    PLOS ONE 2020 ARKIV / DOI
  • Erik Knutsen, Seyed Mohammad Lellahi, Miriam Ragle Aure, Silje Nord, Silje Fismen, Kenneth Bowitz Larsen m.fl.:
    The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers
    Scientific Reports 2020 ARKIV / DOI
  • Jingjing Liu, Wendy J. C. Prager van der Smissen, Margriet J. Collee, Manjeet K. Bolla, Qin Wang, Vessela N. Kristensen m.fl.:
    Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk
    Scientific Reports 2020 ARKIV / DOI
  • Abhilash D. Pandya, Eliézer Jäger, Shahla Bagheri Fam, Anita Höcherl, Alessandro Jäger, Vladimir Sincari m.fl.:
    Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy
    International Journal of Nanomedicine 2019 ARKIV / DOI
  • Karine Flem-Karlsen, Christina Tekle, Tove Ragnhild Øyjord, Vivi Ann Flørenes, Gunhild Mari Mælandsmo, Øystein Fodstad m.fl.:
    p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance
    Scientific Reports 2019 ARKIV / DOI
  • Ketil Andre Camilio, Mengyu Wang, Brynjar Mauseth, Stein Waagene, Gunnar Kvalheim, Øystein Rekdal m.fl.:
    Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model
    Breast Cancer Research 2019 ARKIV / DOI
  • Anne Hansen Ree, Vigdis Nygaard, Hege Elisabeth Giercksky Russnes, Daniel Heinrich, Vegard Nygaard, Christin Johansen m.fl.:
    Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain
    Cancer immunology research 2019 ARKIV / DOI
  • Maria Tunset Grinde, Bylgja Hilmarsdòttir, Hanna Maja Tunset, Ida Marie Henriksen, Jana Kim, Mads Haugland Haugen m.fl.:
    Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer
    Breast Cancer Research 14. mai 2019 ARKIV / DOI
  • Marianne Eikhom Nome, Leslie R. Euceda, Shakila Jabeen, Julia Debik, Tone Frost Bathen, Guro F. Giskeødegård m.fl.:
    Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers
    International Journal of Cancer 24. august 2019 ARKIV / DOI
  • Caroline Elisabeth Nunes-Xavier, Maite Emaldi, Janire Mingo, Tove Ragnhild Øyjord, Gunhild Mari Mælandsmo, Øystein Fodstad m.fl.:
    Author Correction: The expression pattern of pyruvate dehydrogenase kinases predicts prognosis and correlates with immune exhaustion in clear cell renal cell carcinoma (Scientific Reports, (2023), 13, 1, (7339), 10.1038/s41598-023-34087-x)
    Scientific Reports 2023 DOI
  • Markus Fusser, Anders Øverbye, Abhilash D. Pandya, Ýrr Asbjørg Mørch, Sven Even F. Borgos, Wanja Kildal m.fl.:
    Corrigendum to “Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft”, [Journal of Control Release, 293 (2019) 183–192, (Journal of Control Release, (2019) 293(183-192) (S0168365918306928), (10.1016/j.jconrel.2018.11.029))
    Journal of Controlled Release 2022 DOI

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