Ulli Rothweiler
Agata Barzowska,
Barbara Pucelik,
Katarzyna Pustelny,
Alex Matsuda,
Alicja Martyniak,
Jacek Stępniewski
m.fl.:
DYRK1A kinase inhibitors promote β-cell survival and insulin homeostasis
Wenche Stensen,
Ulli Rothweiler,
Richard Alan Engh,
Melissa R. Stasko,
Ilya Bederman,
Alberto C. S. Costa
m.fl.:
Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome
Pankaj Jadhav,
Vikrant Sinha,
Saurabh Chugh,
Chaithanya Kotyada,
Digvijay Bachhav,
Ramandeep Singh
m.fl.:
2.09 Å resolution structure of E. coli HigBA toxin-antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitoxin
Ronny Helland,
Eva katrin Bjørkeng,
Ulli Rothweiler,
Magne Olav Sydnes,
Daniela Maria Pampanin
:
The crystal structure of haemoglobin from Atlantic cod
Marie-Josée Haglund Halsør,
Ulli Rothweiler,
Bjørn Altermark,
Inger Lin Uttakleiv Ræder
:
The crystal structure of the N-acetylglucosamine 2-epimerase
from Nostoc sp. KVJ10 reveals the true dimer
Anna Lucja Czarna,
Wang Jinhua,
Diana Zelencova,
Yao Liu,
Xianming Deng,
Hwan Geun Choi
m.fl.:
Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors
Tina Rise Tuveng,
Ulli Rothweiler,
D.B.R.K. Gupta Udatha,
Gustav Vaaje-Kolstad,
Arne O. Smalås,
Vincent Eijsink
:
Structure and function of a CE4 deacetylase isolated from a marine environment
Ulli Rothweiler,
Wenche Stensen,
Bjørn Olav Brandsdal,
Johan Isaksson,
Frederick Alan Leeson,
Richard Alan Engh
m.fl.:
Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules
Journal of Medicinal Chemistry 2016 DOI
Ulli Rothweiler,
Jonas Eriksson,
Wenche Stensen,
Frederick Alan Leeson,
Richard Alan Engh,
John Sigurd Svendsen
:
Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors
European Journal of Medicinal Chemistry 2015 DOI
Marina Alexeeva,
espen Åberg,
Richard Alan Engh,
Ulli Rothweiler
:
The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.
Osman A.B.S.M. Gani,
Balmukund Thakkar,
Dilip Narayanan,
Kazi Asraful Alam,
Peter Kyomuhendo,
Ulli Rothweiler
m.fl.:
Assessing protein kinase target similarity: Comparing sequence, structure, and cheminformatics approaches
Adele Kim Williamson,
Ulli Rothweiler,
Hanna-Kirsti S. Leiros
:
Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface
espen Åberg,
Bjarte Aarmo Lund,
Alexander Pflug,
Osman A.B.S.M. Gani,
Ulli Rothweiler,
Taiana Maia De Oliveira
m.fl.:
Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool
Biological chemistry 2012 DOI
Michael Orth,
Bernd Mayer,
Kinga Rehm,
Ulli Rothweiler,
Doris Heidmann,
Tad A Holak
m.fl.:
Shugoshin is a Mad1/Cdc20-like interactor of Mad2
EMBO Journal 2011 DOI
Ulli Rothweiler,
espen Åberg,
Kenneth Johnson,
Tom Egil Hansen,
Jorunn B Jørgensen,
Richard Alan Engh
:
p38 alpha MAP Kinase Dimers with Swapped Activation Segments and a Novel Catalytic Loop Conformation
Journal of Molecular Biology (JMB) 2011 DOI
Ulli Rothweiler,
Anna Lucja Czarna,
Lutz Weber,
Grzegorz Popowicz,
Kinga Brongel,
Kaja Kowalska
m.fl.:
NMR Screening for Lead Compounds Using Tryptophan-Mutated Proteins
Journal of Medicinal Chemistry 2008
Ulli Rothweiler,
Anna Lucja Czarna,
Marcin Krajewski,
Jolanta Ciombor,
Cédric Kalinski,
Vladimir Khazak
m.fl.:
Isoquinolin-1-one Inhibitors of the MDM2–p53 Interaction
ChemMedChem 2008
Marcin Krajewski,
Ulli Rothweiler,
Loyola D'Silva,
Sudipta Majumdar,
Christian Klein,
Tad A Holak
:
An NMR-based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments.
Journal of Medicinal Chemistry 2007
Grzegorz Popowicz,
Anna Lucja Czarna,
Ulli Rothweiler,
Aleksandra Szwagierczak,
Marcin Krajewski,
Lutz Weber
m.fl.:
Molecular Basis for the Inhibition of p53 by Mdmx
Cell Cycle 2007
Loyola D'Silva,
Przemyslaw Ozdowy,
Marcin Krajewski,
Ulli Rothweiler,
Mahavir Singh,
Tad A Holak
:
Monitoring the Effects of Antagonists on Protein−Protein Interactions with NMR Spectroscopy
Journal of the American Chemical Society 2005
Marcin Krajewski,
Przemyslaw Ozdowy,
Loyola D'Silva,
Ulli Rothweiler,
Tad A Holak
:
NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro
Nature Medicine 2005
Manikandan Parthasarathy,
Sandhya Sankaran,
Nadig Kavyashree,
Paul Souradip,
Srinivasan Narayanaswamy,
Ulli Rothweiler
m.fl.:
Identification, functional characterization, assembly and structure of ToxIN type III toxin-antitoxin complex from E. coli
Nucleic Acids Research (NAR) 2022 DOI
Man Kumari Gurung,
Tor Olav Berg,
Marie-Josée Haglund Halsør,
Bjørn Altermark,
Ingar Leiros,
Ronny Helland
m.fl.:
Efficient production of sialic acids- Using enzymes for biomass conversion
2017
Man Kumari Gurung,
Tor Olav Berg,
Marie-Josée Haglund Halsør,
Bjørn Altermark,
Ingar Leiros,
Ronny Helland
m.fl.:
Efficient production of sialic acids- Using enzymes for biomass conversion
2017
Tor Olav Berg,
Marie-Josée Haglund Halsør,
Man Kumari Gurung,
Bjørn Altermark,
Ingar Leiros,
Ulli Rothweiler
m.fl.:
From marine rest raw materials to sialic acids: Using enzymes for biomass conversion
2016
Kazi Asraful Alam,
Ulli Rothweiler,
Richard Alan Engh
:
Static and dynamic interactions between the glycine-rich loop of protein kinases and ATP site inhibitors
2016
Marcin Miroslaw Pierechod,
Ulli Rothweiler,
Taianá Maia de Oliveira
:
The structure of Salinibacter ruber Single‐Strand Binding protein reveals a novel, octameric architecture of bacterial SSB proteins
2016
Ulli Rothweiler
:
DYRK1A-PKC412 complex -
disulfide-bridge formation with an anomalous catalytic loop HRD(HCD) cysteine
2016
Marina Alexeeva,
espen Åberg,
Richard Alan Engh,
Ulli Rothweiler
:
The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.
2016
Ulli Rothweiler
:
Drug discovery and design: from the deep ocean to the bedside.
2016
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Forskningsinteresser
Biophysical characterization of enzymes and kinases involved in neurodegenerative diseases