Eva Sjøttem
Stillingsbeskrivelse
Stillingsbeskrivelse
Eva Sjøttem er instituttleder, Institutt for medisinsk biologi ved Det helsevitenskapelige fakultet. Hun er professor i molekylær cellebiologi tilknyttet forskningsgruppen "Autophagy Research Group". Hennes forskning er innen feltet basal biomedisin. Den omhandler identifisering av de molekylære mekanismer som regulerer det cellulære renoveringssystemet autofagi, med fokus på selektiviteten i denne prosessen. Dysregulering av selektiv autofagi kan bidra til utvikling av en rekke sykdommer i mennesker, som neurodegenerering, kreft, hjerte-kar sykdommer og inflammasjon, og bidrar også til aldring.
Professor ved https://uit.no/research/autophagy
Vitenskapelige arbeidsområder
Bhaskar Saha,
Hallvard Lauritz Olsvik,
Geneva L. Williams,
Seeun Oh,
Gry Evjen,
Eva Synnøve Sjøttem
m.fl.:
TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery
Juncal Garcia Garcia,
Anne Kristin McLaren Berge,
Katrine Stange Overå,
Kenneth Bowitz Larsen,
Zambarlal Babanrao Bhujabal,
Andreas Brech
m.fl.:
TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1
Martina Wirth,
Stephane Mouilleron,
Wenxin Zhang,
Eva Sjøttem,
Yakubu Princely Abudu,
Ashish Jain
m.fl.:
Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
Juncal Garcia Garcia,
Katrine Stange Overå,
Waqas Khan,
Eva Sjøttem
:
Generation of the short TRIM32 isoform is regulated by Lys 247 acetylation and a PEST sequence
Thaddaeus Mutugi Nthiga,
Birendra Kumar Shrestha,
Eva Sjøttem,
Trond Lamark,
Terje Johansen
:
CALCOCO1 acts with VAMP ‐associated proteins to mediate ER ‐phagy
Åsa birna Birgisdottir,
Stephane Mouilleron,
Zambarlal Bhujabal,
Martina Wirth,
Eva Sjøttem,
Gry Evjen
m.fl.:
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs
Katrine Stange Overå,
Juncal Garcia Garcia,
Zambarlal Bhujabal,
Ashish Jain,
Aud Karin Øvervatn,
Kenneth Bowitz Larsen
m.fl.:
TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1
Birendra Kumar Shrestha,
Mads Skytte Rasmussen,
Yakubu Princely Abudu,
Jack-Ansgar Bruun,
Kenneth Bowitz Larsen,
Endalkachew Ashenafi Alemu
m.fl.:
NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1
Gry Hoem,
Kenneth Bowitz Larsen,
Aud Karin Øvervatn,
Andreas Brech,
Trond Lamark,
Eva Sjøttem
m.fl.:
The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS
Carmela Fusco,
Barbara Mandriani,
Martina Di Rienzo,
Lucia Micale,
Natascia Malerba,
Dario Cocciadiferro
m.fl.:
TRIM50 regulates Beclin 1 proautophagic activity
BBA - Molecular Cell Research 2018 DOI
Beate Hegge,
Eva Sjøttem,
Ingvild Mikkola
:
Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress
Zambarlal Bhujabal,
Åsa birna Birgisdottir,
Eva Sjøttem,
Hanne Britt Brenne,
Aud Karin Øvervatn,
Sabrina Habisov
m.fl.:
FKBP8 recruits LC3A to mediate Parkin-independent mitophagy
EMBO Reports 05. april 2017 DOI
Mads Skytte Rasmussen,
Stephane Mouilleron,
Birendra Kumar Shrestha,
Martina Wirth,
Rebecca Lee,
Kenneth Bowitz Larsen
m.fl.:
ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8
Autophagy 2017 DOI
Ashish Jain,
Tor Erik Rusten,
Nadja Sandra Katheder,
Julianne Elvenes,
Jack-Ansgar Bruun,
Eva Sjøttem
m.fl.:
P62/sequestosome-1, autophagy-related gene 8, and autophagy in Drosophila are regulated by nuclear factor erythroid 2-related factor 2(NRF2), independent of transcription factor TFEB
Sagar Darvekar,
Julianne Elvenes,
Hanne Brenne,
Terje Johansen,
Eva Sjøttem
:
SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1
Sagar Darvekar,
Cecilie Rekdal,
Terje Johansen,
Eva Sjøttem
:
A Phylogenetic Study of SPBP and RAI1: Evolutionary Conservation of Chromatin Binding Modules
Sagar Ramesh Darvekar,
Agnete Bratsberg Eriksen,
Terje Johansen,
Eva Sjøttem
:
Identification of two independent nucleosome-binding domains in the transcriptional co-activator SPBP
Biochemical Journal 2012 DOI
Julianne Elvenes,
Ernst Ivan Thomassen,
Sylvia Sagen Johnsen,
Katrine Kaino,
Eva Sjøttem,
Terje Johansen
:
Pax6 Represses Androgen Receptor-Mediated Transactivation by Inhibiting Recruitment of the Coactivator SPBP
Endalkachew Alemu,
Eva Sjøttem,
heidi Outzen,
Kenneth Bowitz Larsen,
turid Holm,
Geir Bjørkøy
m.fl.:
Transforming growth factor-beta-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs
Ashish Jain,
Trond Lamark,
Eva Sjøttem,
Kenneth Bowitz Larsen,
Jane Atesoh Awuh,
Aud Karin Øvervatn
m.fl.:
p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
Journal of Biological Chemistry 2010 DOI
Julianne Elvenes,
Eva Sjøttem,
Turid Holm,
Geir Bjørkøy,
Terje Johansen
:
Pax6 localizes to chromatin-rich territories and displays a slow nuclear mobility altered by disease mutations
Cellular and Molecular Life Sciences (CMLS) 2010 DOI
Eva Sjøttem,
Cecilie Rekdal,
Gunbjørg Svineng,
Sylvia sagen Johnsen,
Helle Bagterp Klenow,
Rebecca dale Uglehus
m.fl.:
The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription
Nucleic Acids Research (NAR) 2007 DOI
Steinar Johansen,
Anna Vader,
Eva Sjøttem,
Henrik Nielsen
:
In vivo expression of a group I intron HEG from the antisense strand of Didymium ribosomal DNA
RNA Biology 2006
Peik Haugen,
Odd-Gunnar Wikmark,
Anna Vader,
Dag H. Coucheron,
Eva Sjøttem,
Steinar D. Johansen
:
The recent transfer of a homing endonuclease gene
Peik Haugen,
Odd Gunnar Wikmark,
A Vader,
Dag-Hugo Coucheron,
Eva Sjøttem,
Steinar Johansen
:
The recent transfer of a homing endonuclease gene
Nucleic Acids Research (NAR) 2005
Steinar Daae Johansen,
morten Andreassen,
Åsa birna Birgisdottir,
Dag-Hugo Coucheron,
Christer Einvik,
Tonje Fiskaa
m.fl.:
Group I introns are very common in nuclear SSU rDNA and LSU rDNA of Myxomycetes
Scripta Botanica Belgica 2002
Cecilie Rekdal,
Eva Sjøttem,
Terje Johansen
:
The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators
Journal of Biological Chemistry 2000
Sølvi Anderssen,
Eva Sjøttem,
Gunbjørg Svineng,
Terje Johansen
:
Comparative Analyses of LTRs of the ERV-H Family of Primate-Specific Retrovirus-like ELements Isolated from Marmoset, African Green Monkey, and Man
Virology 1997
Eva Sjøttem,
Cecilie Rekdal,
Terje Johansen
:
Structural and functional analyses of DNA bending induced by Sp1 family transcription factors
Journal of Molecular Biology (JMB) 1997
Eva Sjøttem,
Sølvi Anderssen,
Terje Johansen
:
The Promoter Activity of Long Terminal Repeats of the HERV-H Family of Human Retrovirus-Like Elements Is Critcally Dependent on Sp1 Family Proteins Interacting with a GC/GT Box Located Immediately 3´ to the TATA Box
Journal of Virology 1996
Anne Kristin McLaren Berge,
Juncal Garcia Garcia,
Eva Sjøttem,
Hallvard Lauritz Olsvik
:
The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy
Martina Wirth,
Stephane Mouilleron,
Wenxin Zhang,
Eva Sjøttem,
Yakubu Princely Abudu,
Ashish Jain
m.fl.:
Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity (Journal of Molecular Biology (2021) 433(13), (S0022283621001881), (10.1016/j.jmb.2021.166987))
Journal of Molecular Biology (JMB) 2021 DOI
Agnete B. Kristiansen,
Terje Johansen,
Eva Sjøttem
:
SPBP associates with transcriptionally active chromatin and interacts with RNA polymerase II
2007
Sylvia sagen Johnsen,
Eva Sjøttem,
Terje Johansen
:
SPBP: a putative co-activator of Androgen Receptor Activity
2006
Helle Bagterp Klenow,
Cecilie Rekdal,
Gunbjørg Svineng,
Eva Sjøttem,
Rebecca Dale Uglehus,
Terje Johansen
:
SPBP and TopBP1 interact to enhance Ets-mediated activation of the c-myc promoter
2006
Eva Sjøttem,
Helle Bagterp Klenow,
Cecilie Rekdal,
Gunbjørg Svineng,
Sylvia Sagen Johnsen,
Rebecca Dale Uglehus
m.fl.:
SPBP and TopBP1: Modulators of Androgen Receptor Activity
2006
Peik Haugen,
Odd Gunnar Wikmark,
A Vader,
eva SjØttem,
Steinar Johansen
:
The recent transfer of a homing endonuclease gene
2005
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Forskningsinteresser
Karakterisering av molekylære mekanismer involvert i selektivitet og regulering av den intracellulære prosessen selektiv autofagi. Autofagi er en viktig intracellulær prosess som sørger for degradering av ødelagte, skadelige, overflødige og infeksiøse komponenter. Autofagi er svært viktig for at cellen skal overleve under stressende forhold som sult, virus infeksjon eller mangel på oksygen. Dysregulering av autofagi er implisert i utvikling av forskjellige sykdommer som Alzheimer, Parkinsons og kreft.
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