Bilde av Arranz, Lorena
Bilde av Arranz, Lorena
Stem Cell Aging and Cancer Research Group +4777620841 Tromsø MH2 L.10.340

Lorena Arranz

Group Leader and NCMM Young Associate Investigator


Group Leader of Stem Cells Ageing and Cancer Research Group

Vitenskapelige arbeidsområder

  • Alicia Villatoro, Vincent Cuminetti, Aurora Bernal, Carlos Torroja, Itziar Cossío, Alberto Benguría m.fl.:
    Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
    Nature Communications 2023 DOI
  • Lorena Arranz :
    The Hematology of Tomorrow Is Here-Preclinical Models Are Not: Cell Therapy for Hematological Malignancies
    Cancers 2022 ARKIV / DOI
  • Nuria Vilaplana-Lopera, Vincent Cuminetti, Ruba Almaghrabi, Grigorios Papatzikas, Ashok Kumar Rout, Mark Jeeves m.fl.:
    Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells
    eLIFE 2022 ARKIV / DOI
  • Irene Martínez de Toda, Suresh IS Rattan, Mónica De la Fuente, Lorena Arranz :
    Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities
    Antioxidants 2021 ARKIV / DOI
  • Ianire Mate, Irene Martínez de Toda, Lorena Arranz, Jose Luis Álvarez-Sala, Mónica De la Fuente :
    Accelerated immunosenescence, oxidation and inflammation lead to a higher biological age in COPD patients
    Experimental Gerontology 2021 DOI
  • Alicia Villatoro, Joanna Konieczny, Vincent Cuminetti, Lorena Arranz :
    Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia
    Frontiers in Cell and Developmental Biology 2020 ARKIV / DOI
  • Vincent Cuminetti, Lorena Arranz :
    Bone marrow adipocytes: The enigmatic components of the hematopoietic stem cell niche
    Journal of Clinical Medicine 2019 ARKIV / DOI
  • Dhivya Thiyagarajan, Hege Lynum Pedersen, Natalya Seredkina, Kjersti Daae Horvei, Lorena Arranz, Ramon Sonneveld m.fl.:
    IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene
    Frontiers in Cell and Developmental Biology 2018 ARKIV / DOI
  • Franco Grimolizzi, Lorena Arranz :
    Multiple faces of succinate beyond metabolism in blood
    Haematologica 2018 ARKIV / DOI
  • Joanna Konieczny, Lorena Arranz :
    Updates on old and weary haematopoiesis
    International Journal of Molecular Sciences 2018 ARKIV / DOI
  • Aurora Bernal Mera, Lorena Arranz :
    Nestin-expressing progenitor cells: function, identity and therapeutic implications
    Cellular and Molecular Life Sciences (CMLS) 2018 ARKIV / DOI
  • Lorena Arranz, Maria Del Mar Arriero Sanchez, Alicia Villatoro :
    Interleukin-1β as emerging therapeutic target in hematological malignancies and potentially in their complications
    Blood reviews 2017 ARKIV / DOI
  • Lorena Arranz, Kjersti Juul :
    Nytt håp for voksne leukemipasienter
    31. mars 2023 ARKIV
  • Vincent Cuminetti, Joanna Konieczny, Aurora Bernal, Alicia Villatoro, Hagar Taman, Marko Ristic m.fl.:
    Disruption of succinate receptor signaling promotes myeloproliferation and acute myeloid leukaemia
    HemaSphere 2022 DOI
  • Lorena Arranz, Diego Marin :
    Buscar cura para las leucemias más agresivas es nuestra aventura diaria
    06. februar 2022 FULLTEKST
  • Lorena Arranz, Antonio Armas :
    Celulas madre en las neoplasias hematopoyeticas
    21. april 2020 DATA
  • EJ Cuenca-Zamora, JF Ruiz-Pividal, L Zamora-Plana, B Bellosino, ME De la Morena-Barrio, N Bohdan m.fl.:
    Haematologica 2019
  • Ya-Hsuan Ho, Raquel del Toro, Jose Rivera-Torres, Justyna Rak, Claudia Korn, Andrés García-García m.fl.:
    Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms
    Blood 2018

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    Publikasjoner utenom Cristin

    SELECTED PUBLICATION LIST (2010-2014) h index 27

    Sánchez-Aguilera A, Arranz L, Martín-Pérez D, García-García A, Stavropoulou V, Kubovcakova L, Isern J, Martín-Salamanca S, Langa X, Skoda RC, Schwaller J, Méndez-Ferrer S. Estrogen Signaling Selectively Induces Apoptosis of Hematopoietic Progenitors and Myeloid Neoplasms without Harming Steady-State Hematopoiesis. Cell Stem Cell 2014, 15:791-804. 

    Isern J, García-García A, Martín AM, Arranz L, Martín-Pérez D, Torroja C, Sánchez-Cabo F, Méndez-Ferrer S. The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem-cell-niche function. eLife 2014, 10.7554/eLife.03696. 

    Arranz L, Sánchez-Aguilera A, Martín-Pérez D, Isern J, Langa X, Tzankov A, Lundberg P, Muntión S, Tzeng Y-S, Lai D-M, Schwaller J, Skoda RC, Méndez-Ferrer S. Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature 2014, 512:78-81. 

    Arranz L, Urbano-Ispizúa A, Méndez-Ferrer S. Mitochondria underlie different metabolism of hematopoietic stem and progenitor cells. Haematologica 2013, 98:993-995. 

    Isern J, Martín-Antonio B, Ghazanfari R, Martín AM, del Toro R, Sánchez-Aguilera A, Arranz L, Martín-Pérez D, López JA, Suárez-Lledó M, Marín P, Van Pel M, Vázquez J, Fibbe WE, Scheding S, Urbano-Ispizúa A, Méndez-Ferrer S. Self-renewing human mesenspheres promote hematopoietic stem cell expansion. Cell Rep 2013, 3:1714-1724. 

    Arranz L, Méndez-Ferrer S. Network anatomy and in vivo physiology of mesenchymal stem cells. Inflamm Regen 2013, 33:38-47.

    Arranz L, Naudí A, De la Fuente M, Pamplona R. Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage. Age (Dordr) 2013, 35:621-635. 

    Arranz L, De Castro NM, Baeza I, Giménez-Llort L, De la Fuente M. “Effect of environmental enrichment on the immunoendocrine aging of male and female triple-transgenic 3xTg-AD mice for Alzheimer's disease”. J Alzheimers Dis 2011, 25:727-737. 

    Baeza I, De Castro NM, Arranz L, Fdez-Tresguerres J, De la Fuente M. “Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female mice similar to that in aged males”. Biogerontology 2011, 12:227-238. 

    Baeza I, De Castro NM, Arranz L, De la Fuente M. “Soybean and green tea polyphenols improve immune function and redox status in very old ovariectomized mice”. Rejuvenation Res 2010, 13:665-674. 

    Arranz L, De Castro NM, Baeza I, Maté I, Viveros MP, De la Fuente M. “Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice”. Rejuvenation Res 2010, 13: 415-428. Erratum in: Rejuvenation Res 2010, 13:627. 

    Arranz L, Caamaño J, Lord JM, De la Fuente M. “Preserved immune functions and controlled leucocyte oxidative stress in long-lived mice: possible role of nuclear factor-kappaB”. J Gerontol A Biol Sci Med Sci 2010, 65:941-950. 

    Arranz L, Lord JM, De la Fuente M. “Preserved ex vivo inflammatory status and cytokine responses in naturally long-lived mice”. Age (Dordr) 2010, 32:451-466. 

    Arranz L, De Castro NM, Baeza I, De la Fuente M. “Differential expression of Toll-like receptor 2 and 4 on peritoneal leukocyte populations from long-lived and non-selected old female mice”. Biogerontology 2010, 11:475-482. 


    De la Fuente M, Arranz L. “The importance of the environment in brain aging: Be happy, live longer!” Brain Aging and Therapeutic Interventions 2013, pp: 79-94. DOI 10.1007/978-94-007-5237-5_6.


    Simón Méndez Ferrer, Lorena Arranz Salas and Joan Isern Marín. “Terapia neurorregeneradora/neurocompensatoria para el tratamiento de las neoplasias mieloproliferativas”. Number: P-05571. Country: Spain. Priority date: 10th May 2013. Entity holding: Centro Nacional de Investigaciones Cardiovasculares (CNIC).

    Simón Méndez Ferrer, Abel Sánchez-Aguilera Peño and Lorena Arranz Salas. “Moduladores selectivos de la señalización por los receptores de estrógenos para el tratamiento de las leucemias y neoplasias mieloproliferativas”. Number: P9550ES00. Country: Spain. Priority date: 21st May 2013. Entity holding: Centro Nacional de Investigaciones Cardiovasculares (CNIC).

    MH2 L.10.340

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