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Institutt for kjemi espen.aberg@uit.no +4777646539 Tromsø FPARK G119

Espen Åberg


Forsker, Molekylær biosystemer og bioinformatikk, Senter for Bioinformatikk (SfB)

Stillingsbeskrivelse

Espen Åberg har sin bakgrunn i molekylær bioteknologi med en doktorgrad i molekylær medisin. Etter doktorgradsutdanningen spesialiserte han seg på biologiske signalnettverk, menneskelig og malariakinomikk og legemiddeldesign før han byttet til kreft genomikk ved Norwegian Cancer Genomics Consortium. Han gikk deretter videre til bioinformatisk arbeid, med fokus på genomikk og samspillet mellom vert og mikrober under kolonisering og infeksjon. Han er for tiden ansatt ved ELIXIR Norge som forsker og gjør metagenomiske analyser samt kursing ved Senter for bioinformatikk, UiT, Det arktiske universitetet i Norge (UiT).


  • Clement Ajayi, espen Åberg, Fatemeh Askarian, Johanna U Ericson Sollid, Mona Johannessen, Anne Merethe Hanssen :
    Genetic variability in the sdrD gene in Staphylococcus aureus from healthy nasal carriers.
    BMC Microbiology 16. april 2018 ARKIV / DOI
  • Marina Alexeeva, espen Åberg, Richard Alan Engh, Ulli Rothweiler :
    The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.
    Acta Crystallographica Section D: Biological Crystallography 2015 ARKIV / DOI
  • espen Åberg, Bjarte Aarmo Lund, Alexander Pflug, Osman A.B.S.M. Gani, Ulli Rothweiler, Taiana Maia De Oliveira m.fl.:
    Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool
    Biological chemistry 2012 DOI
  • N. von Bubnoff, S.P. Gorantla, Richard Alan Engh, Taiana Maia De Oliveira, S. Thöne, espen Åberg m.fl.:
    The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro
    Oncogene 2011 DOI
  • Ulli Rothweiler, espen Åberg, Kenneth Johnson, Tom Egil Hansen, Jorunn B Jørgensen, Richard Alan Engh :
    p38 alpha MAP Kinase Dimers with Swapped Activation Segments and a Novel Catalytic Loop Conformation
    Journal of Molecular Biology (JMB) 2011 DOI
  • N von Bubnoff, Richard Alan Engh, espen Åberg, J Sanger, C Peschel, J Duyster :
    FMS-Like Tyrosine Kinase 3-Internal Tandem Duplication Tyrosine Kinase Inhibitors Display a Nonoverlapping Profile of Resistance Mutations In vitro
    Cancer Research 2009 DOI
  • espen Åberg, Knut Martin Torgersen, Bjarne Herold Johansen, Stephen M Keyse, maria Perander, ole morten Seternes :
    Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif
    Journal of Biological Chemistry 2009 DOI
  • maria Perander, espen Åberg, Bjarne Herold Johansen, Bo Dreyer, Ingrid Jenny Guldvik, heidi Outzen m.fl.:
    The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5
    Biochemical Journal 2008 DOI
  • espen Michaelsen, maria Perander, Bjarne Herold Johansen, Catherine Julien, Sylvain Meloche, Stephen M Keyse m.fl.:
    Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4
    Journal of Biological Chemistry 2006
  • Ole Morten Seternes, Theresa Mikalsen, Bjarne Johansen, Espen Michaelsen, CG Armstrong, NA Morrice m.fl.:
    Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway
    EMBO Journal 2004 DOI
  • Clement Ajayi, espen Åberg, Fatemeh Askarian, Johanna U Ericson Sollid, Mona Johannessen, Anne-Merethe Hanssen :
    Genetic variability in the sdrD gene in Staphylococcus aureus from healthy nasal carriers
    2017
  • Marina Alexeeva, espen Åberg, Richard Alan Engh, Ulli Rothweiler :
    The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.
    2016
  • espen Åberg, Ole Morten Seternes, Richard Alan Engh, Franz Gruber :
    Fra Mutasjon til Medisin
    2013
  • N von Bubnoff, SP Gorantla, Richard Alan Engh, Taianá Maia de Oliveira, S Thoene, espen Åberg m.fl.:
    Sorafenib and Nilotinib Are Candidates to Overcome Imatinib Resistance in Myeloproliferation with FIP1L1-PDGFRA
    Blood 2009
  • Espen Åberg, maria Perander, Bjarne Herold Johansen, Catherine Julien, Sylvain Meloche, Stephen M Keyse m.fl.:
    Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAP kinase ERK4/MAPK4
    2006

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    Forskningsinteresser

    Bioinformatikk, metagenomikk, genomikk

    Undervisning

    BIO-3323 Bioinformatics: Genomes and genomics

    KJE-8602 Bioinformatics - genome and genome analysis

    First Marine Microbiome workshop Metagenomics and Bioinformatics for Biodiversity, Nador, Morocco

    Elixir-Excelerate Workshop on Marine Metagenomics, May 2018, Oeiras Portugal