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Foto: Christian Halvorsen
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Institutt for klinisk medisin christer.einvik@uit.no +4777620886 + 47 41548510 Tromsø Fakultet for Humaniora, Samfunnsvitenskap og Lærerutdanning

Christer Einvik


Professor II


  • Utnes, Peter; Løkke, Cecilie; Flægstad, Trond; Einvik, Christer. Clinically Relevant Biomarker Discovery in High-Risk Recurrent Neuroblastoma. Cancer Informatics 2019; Volum 18. ISSN 1176-9351.s 1 - 16.s doi: 10.1177/1176935119832910.
  • Hald, Øyvind Holsbø; Olsen, Lotte; Gallo-Oller, Gabriel; Elfman, Lotta Helena Maria; Løkke, Cecilie; Kogner, Per; Sveinbjørnsson, Baldur; Flægstad, Trond; Johnsen, John Inge; Einvik, Christer. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma.. Oncogene 2018. ISSN 0950-9232.s 1 - 14.s doi: 10.1038/s41388-018-0611-7.
  • Bhavsar, Swapnil Parashram; Løkke, Cecilie; Flægstad, Trond; Einvik, Christer. Hsa-miR-376c-3p targets cyclin D1 and induces G1-cell cycle arrest in neuroblastoma cells. Oncology Letters 2018; Volum 16 (5). ISSN 1792-1074.s 6786 - 6794.s doi: 10.3892/ol.2018.9431.
  • Sarah Andrea, Roth; Hald, Øyvind Holsbø; Fuchs, Steffen; Løkke, Cecilie; Mikkola, Ingvild; Flægstad, Trond; Schulte, Johannes; Einvik, Christer. MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of Cyclin D1, MCL-1 and MYCN. OncoTarget 2018; Volum 9 (26). ISSN 1949-2553.s 18160 - 18179.s doi: 10.18632/oncotarget.24793.
  • Roth, Sarah A; Knutsen, Erik; Fiskaa, Tonje; Utnes, Peter Andree; Bhavsar, Swapnil Parashram; Hald, Øyvind; Løkke, Cecilie; Mestdagh, Pieter; Johansen, Steinar Daae; Flægstad, Trond; Einvik, Christer. Next generation sequencing of microRNAs from isogenic neuroblastoma cell lines isolated before and after treatment. Cancer Letters 2016; Volum 372 (1). ISSN 0304-3835.s 128 - 136.s doi: 10.1016/j.canlet.2015.11.026.
  • Wickström, Malin; Dyberg, Cecilia; Milosevic, Jelena; Einvik, Christer; Calero, Raul; Sveinbjørnsson, Baldur; Sandén, Emma; Darabi, Anna; Siesjö, Peter; Kool, Marcel; Kogner, Per; Baryawno, Ninib; Johnsen, John Inge. Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance. Nature Communications 2015; Volum 6:8904. ISSN 2041-1723.s doi: 10.1038/ncomms9904.
  • Haug, Bjørn Helge; Hald, Øyvind; Utnes, Peter; Roth, Sarah A; Løkke, Cecilie; Flægstad, Trond; Einvik, Christer. Exosome-like extracellular vesicles from MYCN-amplified neuroblastoma cells contain oncogenic miRNAs. (sammendrag) Anticancer Research 2015; Volum 35 (5). ISSN 0250-7005.s 2521 - 2530.
  • Zirath, Hanna; Frenzel, Anna; Oliynyk, Ganna; Segerstrom, Lova; Westermark, Ulrica K.; Larsson, Karin; Persson, Matilda Munksgaard; Hultenby, Kjell; Lehtio, Janne; Einvik, Christer; Påhlman, Sven; Kogner, Per; Jakobsson, Per-Johan; Henriksson, M.. MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells. Proceedings of the National Academy of Sciences of the United States of America 2013; Volum 110 (25). ISSN 0027-8424.s 10258 - 10263.s doi: 10.1073/pnas.1222404110.
  • Buechner, Jochen; Einvik, Christer. N-myc and Noncoding RNAs in Neuroblastoma. Molecular Cancer Research 2012; Volum 10 (10). ISSN 1541-7786.s 1243 - 1253.s doi: 10.1158/1541-7786.MCR-12-0244.
  • Henriksen, Jørn Remi; Büchner, Jochen; Løkke, Cecilie; Flaegstad, Trond; Einvik, Christer. Inhibition of Gene Function in Mammalian Cells Using Short-Hairpin RNA (shRNA). Humana Press 2011 (703) ISBN 978-1-58829-913-0. ISSN 1064-3745.s 189 - 204.s doi: 10.1007/978-1-59745-248-9_13.
  • Büchner, Jochen; Henriksen, Jørn Remi; Haug, Bjørn Helge; Tømte, Ellen; Flaegstad, Trond; Einvik, Christer. Inhibition of mir-21, which is up-regulated during MYCN knockdown-mediated differentiation, does not prevent differentiation of neuroblastoma cells. Differentiation 2011; Volum 81 (1). ISSN 0301-4681.s 25 - 34.s doi: 10.1016/j.diff.2010.09.184.
  • Henriksen, Jørn Remi; Haug, Bjørn Helge; Büchner, Jochen; Tømte, Ellen; Løkke, Cecilie; Flaegstad, Trond; Einvik, Christer. Conditional expression of retrovirally delivered anti-MYCN shRNA as an in vitro model system to study neuronal differentiation in MYCN-amplified neuroblastoma. (fulltekst) BMC Developmental Biology 2011; Volum 11. ISSN 1471-213X.s doi: 10.1186/1471-213X-11-1.
  • Haug, Bjørn Helge; Henriksen, Jørn Remi; Buechner, Jochen; Geerts, Dirk; Tømte, Ellen; Kogner, Per; Martinsson, Tommy; Flægstad, Trond; Sveinbjørnsson, Baldur; Einvik, Christer. MYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 (DKK3) in neuroblastoma. Carcinogenesis 2011; Volum 32 (7). ISSN 0143-3334.s 1005 - 1012.s doi: 10.1093/carcin/bgr073.
  • Buechner, Jochen; Tømte, Ellen; Haug, Bjørn Helge; Henriksen, Jørn Remi; Løkke, Cecilie; Flægstad, Trond; Einvik, Christer. Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma. British Journal of Cancer 2011; Volum 105 (2). ISSN 0007-0920.s 296 - 303.s doi: 10.1038/bjc.2011.220.
  • Nielsen, Henrik; Einvik, christer; Lentz, Thomas E; Hedegaard, MM; Johansen, Steinar. A conformational switch in the DiGIR1 ribozyme involved in release and folding of the downstream I-DirI mRNA. RNA: A publication of the RNA Society 2009; Volum 15 (5). ISSN 1355-8382.s 958 - 967.s doi: 10.1261/rna.669209.
  • Beckert, B; Nielsen, Henrik; Einvik, christer; Johansen, Steinar; Westhof, E; Masquida, B. Molecular modelling of the GIR1 branching ribozyme gives new insight into evolution of structurally related ribozymes. EMBO Journal 2008; Volum 27 (4). ISSN 0261-4189.s 667 - 678.s doi: 10.1038/emboj.2008.4.
  • Henriksen, Jørn Remi; LØkke, cecilie; Hammerø, Martin; Geerts, Dirk; Versteeg, R; Flaegstad, Trond; Einvik, christer. Comparison of RNAi efficiency mediated by tetracycline-responsive H1 and U6 promoter variants in mammalian cell lines. Nucleic Acids Research (NAR) 2007; Volum 35 (9). ISSN 0305-1048.s doi: 10.1093/nar/gkm193.
  • Wikmark, Odd Gunnar; Einvik, Christer; De Jonckheere, JF; Johansen, Steinar. Short-term sequence evolution and vertical inheritance of the Naegleria twin-ribozyme group I intron. BMC Evolutionary Biology 2006; Volum 6. ISSN 1471-2148.
  • Fiskaa, Tonje; Lundblad, Eirik Wasmuth; Henriksen, Jørn Remi; Johansen, Steinar; Einvik, Christer. RNA reprogramming of alpha-mannosidase mRNA sequences in vitro by myxomycete group IC1 and IE ribozymes. The FEBS Journal 2006; Volum 273. ISSN 1742-464X.
  • Einvik, Christer; Fiskaa, Tonje; Lundblad, Eirik Wasmuth; Johansen, Steinar. Optimization and application of the group I ribozyme trans-splicing reaction. Methods in molecular biology 2004; Volum 252. ISSN 1064-3745.s 359 - 371.
  • Lundblad, Eirik Wasmuth; Einvik, Christer; Rønning, S; Haugli, Kari B.; Johansen, Steinar. Twelve group I Introns in the same pre-rRNA transcript of the myxomycete Fuligo septica: RNA processing and evolution. Molecular Biology and Evolution (MBE) 2004; Volum 21. ISSN 0737-4038.s 1283 - 1293.
  • Nielsen, Henrik; Fiskaa, Tonje; Birgisdottir, Åsa Birna; Haugen, Peik; Einvik, christer; Johansen, Steinar. The ability to form full-length intron RNA circles is a general property of nuclear group I introns. RNA: A publication of the RNA Society 2003; Volum 9. ISSN 1355-8382.s 1464 - 1475.
  • Johansen, Steinar Daae; Andreassen, morten; Birgisdottir, Åsa birna; Coucheron, Dag-Hugo; Einvik, Christer; Fiskaa, Tonje; Haugli, kari b.; Lundblad, Eirik Wasmuth; Sjøttem, Eva; SkjÆveland, ingrid; Wikmark, Odd Gunnar. Group I introns are very common in nuclear SSU rDNA and LSU rDNA of Myxomycetes. Scripta Botanica Belgica 2002; Volum 22. ISSN 0779-2387.s 43 - .
  • Johansen, Steinar; Einvik, christer; Nielsen, Henrik. DiGIR1 and NaGIR1: naturally occurring group I-like ribozymes with unique core organization and evolved biological role. Biochimie 2002; Volum 84. ISSN 0300-9084.s 905 - 912.
  • Einvik, christer; Nielsen, Henrik; Nour, R; Johansen, Steinar. Flanking sequences with essential role in hydrolysis of a self-cleaving group I-like ribozyme. Nucleic Acids Research (NAR) 2000; Volum 28. ISSN 0305-1048.s 2194 - 2200.
  • Suenaga, Yusuke; Einvik, Christer; Takatori, Atsushi; Zhu, Yuyan. Editorial: Molecular Mechanisms and Treatment of MYCN-Driven Tumors. Frontiers in Oncology 2021; Volum 11. ISSN 2234-943X.s doi: 10.3389/fonc.2021.803443.
  • Flægstad, Trond; Haug, Bjørn Helge; Buechner, Jochen; Henriksen, Jørn Remi; Kogner, Per; Martinson, Tommy; Sveinbjørnsson, Baldur; Geerts, Dirk; Tømte, Ellen; Einvik, Christer. MYCN-REGULATED MIRNA-92 INHIBITS SECRETION OF THE TUMOR SUPPRESSOR DICKKOPF-3 (DKK3) IN NEUROBLASTOMA. Pediatric Blood & Cancer 2011; Volum 57 (5). ISSN 1545-5009.s 738 - 739.
  • Flaegstad, Trond; Einvik, christer; Henriksen, Jørn Remi. Targeted MYCN suppression and its effect on miRNA in neuroblastoma. (fulltekst) 2010 ISBN 978-82-7589-285-8.
  • Henriksen, Jørn Remi; Büchner, Jochen; Haug, Bjørn Helge; Einvik, christer; Flaegstad, Trond. Combination of RA Treatment and MYCN-knockdown in MYCN Amplified Neuroblastoma. NOPHO annual meeting 2010 2010-05-26 - 2010-05-29 2010.
  • Henriksen, Jørn Remi; Haug, Bjørn Helge; Büchner, Jochen; LØkke, cecilie; Flaegstad, Trond; Einvik, christer. Conditional MYCN knockdown using shRNAs encoded by retrovirus vectors. Advances in Neuroblastoma Research 2010 2010-06-21 - 2010-06-24 2010.
  • Haug, Bjørn Helge; Henriksen, Jørn Remi; Sveinbjørnsson, Baldur; Flaegstad, Trond; Einvik, christer. The tumour suppressor DKK3 is a direct target of MYCN regulated miRNAs. NOPHO annual meeting 2010 2010-05-26 - 2010-05-29 2010.
  • Flaegstad, Trond; Büchner, Jochen; Henriksen, Jørn Remi; LØkke, cecilie; Tømte, Ellen; Haug, Bjørn Helge; Einvik, christer. MYCN PARTICIPATES IN A REGULATORY MIRNA NETWORK IN MYCN-AMPLIFIED NEUROBLASTOMA. Pediatric Blood & Cancer 2009; Volum 53 (5). ISSN 1545-5009.s 807 - 807.
  • Büchner, Jochen; Henriksen, Jørn Remi; LØkke, cecilie; Flaegstad, Trond; Einvik, christer. MicroRNA-101 as a potential regulator of MCYN expression in neuroblastoma. SIOP Congress 2008-10-02 - 2008-10-06 2008.
  • Büchner, Jochen; Henriksen, Jørn Remi; LØkke, cecilie; Flaegstad, Trond; Einvik, christer. Effect of MYCN downregulation on microRNA expression in neuroblastoma. SIOP Congress 2008-10-02 - 2008-10-06 2008.
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    Fakultet for Humaniora, Samfunnsvitenskap og Lærerutdanning