KJE-3201 Bioinorganic Chemistry - 10 stp
Admission requires a Bachelor`s degree (180 ECTS) in Chemistry or equivalent. A thorough knowledge of elementary university-level organic and inorganic chemistry, corresponding to a grade of C or better in KJE-1002 and KJE-1004, will be assumed, as will a modest exposure to elementary biochemistry and NMR spectroscopy. A high level of fluency with basic concepts of organic and inorganic structure and bonding, in particular elementary ligand field theory, and with organic reaction mechanisms will be assumed.
Local admission, application code 9371 - singular courses at Master's level.
The student should acquire the following knowledge, skills and competencies.
- A broad knowledge of metalloprotein active sites and metal-containing cofactors and of metal-nucleic-acid interactions, as outlined in a standard textbook;
- A detailed mechanistic knowledge of iron- and copper-containing enzymes involved in dioxygen metabolism;
- A detailed mechanistic knowledge of specialized cofactors including iron-sulfur clusters, cobalamin, and molybdopterin;
- Geometric and electronic-structural aspects of metal-NO interactions;
- Aspects of metals in medicine, such as platinum anticancer drugs and technetium radiopharmaceuticals;
- Aspects of environmental bioinorganic chemistry, such as arsenic toxicity
- Have a convincing command of the basic facts of bioinorganic chemistry, particularly the major classes of metalloenzymes,
- Ability to describe and discuss the geometric and electronic structures of bioinorganic systems in terms of ligand field theory;
- Above all, to be able to propose and test mechanistic hypotheses for a wide range of metalloenzymes and model systems.
- To "think on one's feet" about the electronic structures and mechanisms of metalloenzymes and their synthetic models;
- To be able to read the current bioinorganic literature and appreciate it from a mechanistic perspective.