Disputas – Master in Science (biomedical sciences) Md Jalal Uddin

Avhandlingen er tilgjengelig her! / The doctoral thesis is available here!


Auditoriet er åpent for publikum. Disputasen strømmes og et opptak vil være tilgjengelig i et døgn.
The auditorium is open to the public. The defense will still be streamed, and a recording of the disputation will be available for 24 hours.


Prøveforelesning over oppgitt emne starter kl. 09.15 / The trial lecture starts at 09.15
Tittel/Title:  "Anti-virulence strategies for treating bacterial infections: Opportunities and limitations”
Prøveforelesningen strømmes her / The trial lecture will be streamed here.

Disputasen starter kl. 11.15 / The defense starts at 11.15
Disputasen strømmes her / The defense will be streamed here



Populærvitenskapelig sammendrag av avhandlingen/ Summary of the thesis

Staphylococcus aureus and Klebsiella pneumoniae typically exist harmlessly within our bodies but can turn into formidable pathogens when they evade immune defenses, leading to severe infections. These pathogens are increasingly difficult to treat due to the rise of antibiotic-resistant strains such as methicillin-resistant S. aureus (MRSA) and carbapenem-resistant K. pneumoniae.
To search for new putative targets of antimicrobial drugs, this study utilized activity-based protein profiling (ABPP), a chemoproteomic technique to identify new druggable target enzymes in these pathogens and functionally validate them in various models, including human-derived organoids and Galleria mellonella infection models. Overall, this study identified and functionally validated four novel targets that could be important in the host-pathogen interface and bacterial physiology.
This study provides substantial insights into the molecular mechanisms underlying the virulence and cell physiology of these pathogens and suggests that targeting these enzymes could enhance the effectiveness of existing antibiotics and bolster human immune defenses, offering new hope in the battle against resistant bacterial infections.


Veiledere/ Supervisors:
Hovedveileder/Main supervisor:
Førsteamanuensis Christian Lentz, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

Biveiledere/supervisors:
Professor Mona Johannessen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Professor Pål Jarle Johnsen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Førsteamanuensis Veronika K. Pettersen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet


Bedømmelseskomité/Defensecomitee:
Professor Jose Bengoechea, Queen's University Belfast – 1. opponent.
Amanuensis Michaela Prothiwa, University of Antwerp - – 2. opponent.
Førsteamanuensis Anett Kristin Larsen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.


Disputasleder/ Leader of defense:
Professor Ole-Jakob How, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.