Emerging evidence imply for possible involvement of P-selectin in the pathogenesis of VTE. However, it is still unknown whether plasma P-selectin levels predict future incident VTE and whether P-selectin plays an active role in disease pathogenesis, and if so, by which mechanisms it operates. The aims of this project is to investigate the role of free P-selectin and P-selectin-positive extracellular vesicles in plasma and the risk of future VTE, and as biomarkers of acute VTE. We will develop a bead-based assay to quantify the amount of EV-bound P-selectin. We will use data from a nested case-control study (derived from Tromsø 4) to study P-selectin and risk of future VTE, and a cross-sectional study of patients referred to hospital with suspected DVT to study the diagnostic performance of EV-bound and total P-selectin in plasma for acute DVT.
Members:
Publications:
Plasma levels of P-selectin and future risk of incident venous thromboembolism