News archive

Read more about our projects, the CANS organization, outreach activites and our scientific publications.

Open and download the 2022 Annual Report here.

Welcome to CANS!

There are even more positives to probiotics than previously thought. As well as helping preterm babies gain a healthy gut microbiome, they reduce the chance of harmful bacteria building resistance to antibiotics.

Every year about 15 million preterm babies are born worldwide who suffer from a risk of infection and inflammation. Being born many weeks or even months before their expected due date, their immune system is less mature than in term babies, including impaired gut barrier function and quite different microbial community in the large intestine.

Giving antibiotics to preterm infants disrupts the maturing process of the gut microbiome, and makes them more vulnerable to antimicrobial resistant variants of harmful bacteria.

Researchers at UiT The Arctic University of Norway have found that probiotics help preterm babies achieve a better bacterial balance in the gut and eradicate harmful bacteria, as the under-developed gut microbiome works its way into maturity.  

Helping preterm babies catch up with their fellow newborns

The researchers behind the study used data from a clinical trial where stool samples were collected four times in the first year of life from 72 babies in six Norwegian neonatal intensive care units. They then divided the samples into groups depending on whether the newborns were given antibiotics, a combination of antibiotics and probiotics, or none. The microbial DNA in the samples was sequenced to follow the development of the babies’ gut microbiota.  

The study supports the findings of other recent studies showing that probiotics boost normal microbiota and maturation in preterm infants to levels comparable to full-term newborns.

Less antimicrobial resistance

But there is also another finding that should be very interesting to medical staff around the world fighting antimicrobial resistance, or AMR. With probiotics, the extremely preterm infants had decreased risk of carrying antimicrobial resistant bugs despite frequent treatment with antibiotics.

- We discovered that probiotic-supplemented preterm newborns have bacteria that carry substantially fewer antibiotic-resistance genes, than infants that did not get probiotic supplements, says doctoral research fellow Ahmed Bargheet, the first author of the study.

About the study

The study was carried out at the Pediatric Research Group for Infections and Host-Microbe Interaction Research Group at the Centre for New Antibacterial Strategies (CANS), UiT The Arctic University of Norway. The work was done in cooperation with the University Hospital of North Norway and funded by the Odd Berg Group, the Northern Norway Regional Health Authority and Tromsø Research Foundation. 

Scientific reference

“Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments”: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00178-0/fulltext 

Contact information

Ahmed Bargheet
Doctoral research fellow
https://en.uit.no/ansatte/person?p_document_id=745394

Veronika K. Pettersen
Associate professor
https://en.uit.no/ansatte/person?p_document_id=543168&p_dimension_id=88110

Claus Klingenberg
Professor and senior physician
https://en.uit.no/ansatte/person?p_document_id=41727&p_dimension_id=88116

Facts about probiotics

Probiotics are live bacteria and yeasts promoted as having various health benefits. They're usually added to yoghurts or taken as food supplements, and are often described as "good" or "friendly" bacteria: https://www.nhs.uk/conditions/probiotics/

The microbiome explained

Picture a bustling city on a weekday morning, the sidewalks flooded with people rushing to get to work or to appointments. Now imagine this at a microscopic level and you have an idea of what the microbiome looks like inside our bodies, consisting of trillions of microorganisms (also called microbiota or microbes) of thousands of different species: https://www.hsph.harvard.edu/nutritionsource/microbiome/

We have regular seminars presented by our team and research partners.

Stay updated about upcoming talks and join our mailing list.

To join the email list, please email lise.nordgard@uit.no

Thanks to all speakers and participants who all contributed to a great CANS day!

Kristin Hegstad og kollegene kikket inn i tarmbakteriens indre og avslørte hvorfor legenes siste utvei ikke ville fungert.

Les mer i Dagen Medisin, her!

Når vi har tatt imot krigsofre fra Ukraina, har vi sett at vi er godt rustet til å gi avansert medisinsk og kirurgisk behandling. Men det har også blottlagt vår sårbare antibiotikaberedskap.

Les mer i aftenposten - klikk her!

A PhD position in Computer Science is available at the Department of Computer Science affiliated with the Health Data Lab research group and Centre for New Antibacterial Strategies.

For more information about the position, click here!

Deadline of application: 6th December 2022

For further information about the position, contact Associate Professor Einar J Holsbø:

November the 18 is the European Antibiotic Awareness Day (EAAD).

You can already the day before follow a digital event hosted by European Centre for Disease and prevention and control (ECDC) with the theme:

"Preventing Antimicrobial Resistance Together"

     Click here for more information!

Gabriel Magno de Freitas Almeida has a nw publication on how Mucosal Environment Induces Phage Susceptibility in Streptococcus mutant!

For more information, click here!

Sybil has just published in the Researchers’ zone in Science Norway (the English version of forskning.no)

To read the whole article, click here!

Usage og Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway

This report, which is the twenty-first annual joint report from NORM and NORM-VET, presents data on resistance and usage for 2021.

REPORT

VETpodden: Gunnar skov Simonsen og Anne Merte Urdal presenterer hovedfunnene 

Earlier this month, Uppsala Antibiotic Center hosted a meeting with CANS and seven other AMR centers based in Norway, Sweden, Denmark and Finland.

The goal of the meeting was to discuss structure, work activities and possible collaborations between Nordic centers with an AMR focus, to hopefully strengthen the Nordic cooperation on AMR.

From CANS Arnfinn Sundsfjord, Klara Stensvåg and Lise Nordgård attended the meeting.

Antibiotikabruken i Norge har gått ned med en tredel på ti år. Les mer i Dagen Medisin

From publications to activities, get your annual CANS update here. 

Click here to download the 2021 annual report.

CANS-seminar with professor Nicholas Feasey from the Liverpool School of Tropical Medicine.

“Antimicrobial resistance is predicted to impact most heavily on sub-Saharan Africa, yet how much is really known about clinical outcomes from drug-resistant infection in this setting? I will present observational data from multiple clinical cohorts recruited from Queen Elizabeth Central Hospital, Blantyre, Malawi and the surrounding communities in the Southern Region of Malawi.

I will describe the burden of AMR and DRI in this setting and the distribution of extended spectrum beta-lactamase producing bacteria in humans, animals and the environment. Lastly I will consider approaches to tackling AMR in Southern Africa.”

Although antibiotics target bacteria, their common side effect is the outgrowth of gut fungi. The use of antibiotics in infancy is connected to the risk of allergic diseases later in life, but the underlying molecular mechanisms remain vague.

Associate professor Veronika K. Pettersen at UiT and CANS has recently reported the consequences of fungal overgrowth in a mice model. While gut bacteria primarily communicate with the immune system via metabolites, gut fungi seemed to modulate the host cells through direct cell contact and fungal proteins in particular.

"Our results suggest that an increased abundance of certain gut fungal species in early life may affect the developing intracellular attributes of epithelial and immune cells."

The results from the study show that antibiotic use can be catastrophic for the maturing immune system by damaging chemical communication between the gut bacteria and immune cells.

The study was done during Veronikas postdoc stay at the University of Calgary in Canada. The paper was published online on Biomedcentral on 22 February 2022.

Scientific reference
Metaproteomic profiling of fungal gut colonization in gnotobiotic mice (Biomedcentral)

"Introducing aspects of the work of a National Reference Centre". 

Presenter: Guido Werner, Department of infectious Diseases, Robert Koch Institut.

See the recording on Vimeo instead?

PhD Student  Jónína Sæunn Guðmundsdóttir has published her first articel in EBioMedicine  - Congratulations! 

Understanding drivers of antibiotic resistance evolution is fundamental for designing optimal treatment strategies and interventions to reduce the spread of antibiotic resistance. Various cytotoxic drugs used in cancer chemotherapy have antibacterial properties, but how bacterial populations are affected by these selective pressures is unknown. Here we test the hypothesis that the widely used cytotoxic drug methotrexate affects the evolution and selection of antibiotic resistance.

Read the full article here

Hittil har Norge sluppet unna høye antall dødsfall forårsaket av resistente bakterier. Det skyldes både hell og dyktighet, tror seksjonsoverlege Arnfinn Sundsfjord hos 20-årsjubilanten K-res.

Les hele artikkelen i Bioingeniøren, ved å klikke her!

Ekspertuttalelse i farmatid.no om betydningen av bakteriosiner som legemdiler og forskningen som gjøres ved NMBU.

Klikk her for å lese artikkelen.

In a new publication in Scientific Reports, Adriana Sanabrina, Jessin Janice, Erik Hjerde, Gunnar Skov Simonsen and Anne-Merethe Hanssen used shotgun-metagenomics to predict antibiotic resistance and virulence determinants in S. aureus from periprosthetic tissues.

Click here to read more!

The CAS Board of Directors has selected two Young CAS Fellow projects for the period of January 2022 to December 2023. Veronika Kuchařová Pettersen, associate professor at UiT The Arctic University og Norway (UiT), will lead the Young CAS fellow project: Infant Gut Microbiome Acquisition: Off to a Healthy Start.

Siden 2012 har det vært en markant nedgang i total antibiotikabruk i Norge. Tallene fra NORM 2020 viser en reduksjon på 32 prosent. Les hele artikkelen i Dagens Medisin

Fellesrapporten fra Veterinærinstitututtet og Folkehelseinstituttet for 2020 kan leses via FHIs hjemmesider. 

Congratulation to Christian Lentz, Veronika Kucharov Pettersen, Mona Johannessen, Pål Jarle Johnsen and Arnfinn Sundsfjord for receiving research funding from Helse Nord.

For more information click here.

Forskerne oppdaget bakterien ved en tilfeldighet. De skulle først og fremst studere hudbakterier som kan føre til alvorlige infeksjoner, spesielt hos fortidligfødte spedbarn.

Så dukket det en ny type bakterie opp i prøveglasset.

Forskerne har gitt den navnet Staphylococcus borealis fordi den er funnet i nord, og fordi den kan være tilpasset et nordlig klima.

Les forskning.no for mer om saken.

Et sammendrag av artikkelen kan også leses her.

Brage Larsen Sollund, distriktssjef i Kreftforeningen har sammen med Arnfinn Sundsfjord, leder for CANS, skrevet en kronikk i Nordnorsk debatt om viktigheten av forskningen som gjøres i CANS på antibiotikaresisten. Klikke her for å lese kronikken

Sybil Akua Okyerewa Obuobi is a postdoctoral fellow at the Department of Pharmacy and has received TFS starting grant for the project: 

COALITION: BaCteria respOnsive And intrinsicaLly active anTimIcrObial Nanohybrids

About CANS in LVS info, 2/2020: The research of several groups affiliated to CANS has been described in LVS info, medlemsblad 2/2020

Centre for New Antibacterial Strategies (CANS) receives attention in Norsk Farmaceutisk Tidsskrift: Forskere i nord samles til krig mot antibiotikaresistens

CANS - Tverrfaglig senter for nye antibakterielle strategier ved Norges universitet. NBS-nytt 03.08.2020, av Dr. scient Lise Nordgård, Prof. Klara Stensvåg (BFE), og Prof. Arnfinn Sundsfjord (Senterleder CANS).

Tromsø-forskere går foran i kampen mot en pandemi som er skumlere enn korona. Kronikk, Nordnorsk debatt, 23. November 2020, av Brage Larsen Sollund, distriktssjef i Kreftforeningen og Arnfinn Sundsfjord, leder for uiT`s Senter for nye antibakterielle strategier (CANS)

2020

Achten, N.B., Klingenberg, C., Plötz, F.B. (2020) Neonatal Early-Onset Sepsis Calculator and Antibiotic Therapy-Reply. JAMA Pediatr. 2020 May 1,174(5):508-509. doi:10.1001/jamapediatrics.2019.6269. PMID: 32150235 

Dretvik, T., Solevåg, A.L., Finvåg, A., Størdal ,E.H., Størdal, K., Klingenberg, C. (2020) Active antibiotic discontinuation in suspected but not confirmed early-onset neonatal sepsis-A quality improvement initiative. Acta Paediatr. 2020 Jun,109(6):1125-1130. doi: 10.1111/apa.15202. Epub 2020 Feb 15. PMID: 31999863 https://doi.org/10.1111/apa.15202

Elvebakk, A., Park, S.G., Haeng, C., Rämä, T. (2020) Psoroma capense and P. esterhuyseniae (Pannariaceae), two new alpine species from South                Africa. The Lichenologist 2020 ,Volum 52.(5) s. 345-352. https://doi.org/10.1017/S0024282920000377

Ezawa, T., Saito, R., Suzuki, S., Sugiyama, S., Sylte, I., Kurita, N. (2020) Protonation states of central amino acids in a zinc metalloprotease complexed with inhibitor: Molecular mechanics optimizations and ab initio molecular orbital calculations. Biophys Chem. 2020 Jun,261:106368. https://doi.org/10.1016/j.bpc.2020.106368

Ezawa ,T., Sugiyama, S., Ara, A., Sylte, I., Kurita, N. (2020) Design of galardine analogs as putative psudolysin inhibitors based on ab initiofragment molecular orbital calculations. J Biomol Struct Dyn. 2020 Jul,38(11):3307-3317. Epub 2019 Aug 29.PMID: 31422741 https://doi.org/10.1080/07391102.2019.1656672

Fellner, M., Lentz, C.S., Jamieson, S.A., Brewster, J.L., Chen, L., Bogyo, M., Mace, P.D. (2020) Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of Staphylococcus aureus. ACS Infect Dis. 2020 Oct 9,6(10):2771-2782. https://pubmed.ncbi.nlm.nih.gov/32865965/

Ferrand, R.A., McHugh, G., Rehman, A.M., Mujuru, H., Simms, V., Majonga, E.D., Nicol, M.P., Flaegstad, T., Gutteberg, T.J., Gonzalez-Martinez, C., Corbett, E.L., Rowland-Jones, S.L., Kranzer, K., Weiss, H.A., Odland, J.O., BREATHE Trial Group.(2020) Effect of Once-Weekly Azithromycin vs Placebo in Children With HIV-Associated Chronic Lung Disease: The BREATHE Randomized Clinical Trial. JAMA Netw Open. 2020 Dec 1,3(12):e2028484. https://doi.org/10.1001/jamanetworkopen.2020.28484

Flygel, T.T., Sovershaeva, E., Claassen-Weitz, S., Hjerde, E., Mwaikono, K,S., Odland, J.Ø., Ferrand, R.A., Mchugh, G., Gutteberg, T.J., Nicol, M.P., Cavanagh, J.P., Flægstad, T., BREATHE Study Team. (2020) Composition of Gut Microbiota of Children and Adolescents With Perinatal Human Immunodeficiency Virus Infection Taking Antiretroviral Therapy in Zimbabwe. J Infect Dis. 2020 Jan 14,221(3):483-492. https://doi.org/10.1093/infdis/jiz473

Fröhlich, C., Gama, J.A., Harms, K., Hirvonen ,V.H.A., Lund, B.A., van der Kamp, M.W., Johnsen, P.J., Samuelsen, Ø.,Leiros H.-K.S. (2020) Cryptic β-lactamase evolution is driven by low β-lactam concentrations. Submitted to Communications Biology, Jan 2021 https://doi.org/10.1101/2020.12.01.404343

Fröhlich, C., Sørum, V., Huber, S., Samuelsen, Ø., Berglund, F., Kristiansson, E., Kotsakis, S.D., Marathe, N.P., Larsson, D.G.J., Leiros, H.S.(2020) Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1. J Antimicrob Chemother. 1,75(9):2554-2563. https://doi.org/10.1093/jac/dkaa175.

Gama, J.A., Kloos, J., Johnsen, P.J., Samuelsen, Ø. (2020) Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates. Sci Rep. 9,10(1):9332. https://doi.org/10.1038/s41598-020-66239-8

Gama, J.A., Zilhão, R., Dionisio, F. (2020). Plasmid Interactions Can Improve Plasmid Persistence in Bacterial Populations. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2020.02033

Gama, J.A., Fredheim, E.G.A., Cléon, F., Reis, A.M., Zilhão, R., Dionisio, F. (2020). Dominance Between Plasmids Determines the Extent of Biofilm Formation. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2020.02070

Giordani, B., Basnet, P., Mishchenko, E., Luppi, B., Skalko-Basnet, N. (2020). Utilizing liposomal quercetin and gallic acid in localized treatment of vaginal Candida infections. Pharmaceutics 2020, Volum 12:9.(1) s. 1-21, https://doi.org/10.3390/pharmaceutics12010009

Goll, R., Johnsen, P.H., Hjerde, E., Diab, J., Valle, P.C., Hilpusch, F., Cavanagh, J.P. (2020) Effects of fecal microbiota transplantation in subjects with irritable bowel syndrome are mirrored by changes in gut microbiome. Gut Microbes. 2020 Nov 9,12(1):1794263. https://doi.org/10.1080/19490976.2020.1794263

Götzinger, F., Santiago-García, B., Noguera-Julián, A., Lanaspa, M., Lancella, L., Calò Carducci, F.I., Gabrovska, N., Velizarova, S., Prunk, P., Osterman, V., Krivec, U., Lo Vecchio, A., Shingadia, D., Soriano-Arandes, A., Melendo, S., Lanari, M., Pierantoni, L., Wagner, N., L'Huillier, A.G., Heininger, U., Ritz, N., Bandi, S., Krajcar, N,, Roglić, S., Santos, M., Christiaens, C., Creuven, M., Buonsenso, D., Welch, S.B., Bogyi, M,, Brinkmann, F., Tebruegge, M., ptbnet COVID-19 Study Group (Klingenberg C) (2020). COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health. 2020 Sep,4(9):653-661 https://doi.org/10.1016/S2352-4642(20)30177-2

Hagestad, O.C., Andersen, J.H., Altermark, B., Hansen, E., Rämä, T. (2020) Cultivable marine fungi from the Arctic Archipelago of Svalbard and their antibacterial activity. Mycology: An International Journal on Fungal Biology 2020, volume 11. (3). https://doi.org/10.1080/21501203.2019.1708492

Hansen, K.Ø., Hansen, I.K.Ø., Richard, C.S.M., Jenssen, M., Andersen, J.H., Hansen, Holst, E. (2020). Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons. Natural Product Communications 2021, Volum 16 (2). ISSN 1934-578X.s 1 - 8.s https://doi.org/10.3390/ijms21155460.

Hansen, I.K.Ø., Lövdahl, T., Simonovic, D., Hansen, K.Ø., Andersen, A.J.C., Devold, H., Richard, C.S.M. Andersen, J.H., Strøm, M.B. & Haug, T. (2020). Antimicrobial activity of small synthetic peptides based on the marine peptide turgencin A: prediction of antimicrobial peptide sequences in a natural peptide and strategy for optimization of potency. International Journal of Molecular Sciences, 21(15): 5460. https://doi.org/10.3390/ijms21155460.

Hansen, I.K.Ø, Isaksson, J., Poth, A.G., Hansen, K.Ø., Andersen, A.J.C., Richard, C.S., Blencke, H.M., Stensvåg, K., Craik, D.J. & Haug, T. (2020). Isolation and characterization of antimicrobial peptides with unusual disulfide connectivity from the colonial ascidian Synoicum turgens. Marine Drugs, 18(1):51. https://doi.org/10.3390/md18010051.

Hegstad, K., Mylvaganam, H., Janice, J.J., Josefsen, E., Sivertsen, A., Skaare, D. (2020). The role of horizontal gene transfer in the development of multidrug resistance in Haemophilus influenzae. mSphere 5:e00969-19. https://doi.org/10.1128/ mSphere.00969-19.

Hemmingsen, D., Mikalsen, C., Hansen, A.R., Fjalstad, J.W., Stenklev, N.C., Klingenberg, C. (2020) Pediatrics. Hearing in Schoolchildren After Neonatal Exposure to a High-Dose Gentamicin Regimen. 2020 Feb,145(2):e20192373. Epub 2020 Jan 8. PMID: 31915192 https://doi.org/10.1542/peds.2019-2373

Hira, J., Bentdal, S., Devold, H., Stensvåg, K. & Landfald, B. (2019) Vibrio echinoideorum sp. nov., isolated from an epidermal lesion on the test of a green sea urchin (Strongylocentrotus droebachiensis). International Journal of Systematic and Evolutionary Microbiology, 69(8):2277–2282. https://doi.org/doi:10.1099/ijsem.0.003462.

Hira, J., Uddin, J., Haugland, M.M., Lentz, C.S. (2020)From Differential Stains to Next Generation Physiology: Chemical Probes to Visualize Bacterial Cell Structure and Physiology. Molecules. 2020 Nov, 25(21): 4949.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663024/

Hira, J., Wolfson, D., Andersen, A.J.C., Haug, T. & Stensvåg, K. (2020). Autofluorescence mediated red spherulocyte sorting provides insights into the source of spinochromes in sea urchins. Scientific Reports, 10(1):1149 https://doi.org/http://dx.doi.org10.1038/s41598-019-57387-7.

Håkonsholm, F., Hetland, M.A.K., Svanevik, C.S., Sundsfjord, A. Lunestad, B.T., Marathe, N. P. (2020) Antibiotic Sensitivity Screening of Klebsiella spp. and Raoultella spp. Isolated from Marine Bivalve Molluscs Reveal Presence of CTX-M-Producing K. pneumoniae. Microorganisms. 2020 Dec, 8(12):1909.  https://doi.org/10.3390/microorganisms8121909

Jensen, V.V.S., Furberg, A-S., Slotved, H.S., Bazhukova, T., Haldorsen, B., Caugant, D.A., Sundsfjord, A., Valentiner-Branth, P., Simonsen, G.S. (2020) Epidemiological and molecular characterization of Streptococcus pneumoniaecarriage strains in pre-school children in Arkhangelsk, northern European Russia, prior to the introduction of conjugate pneumococcal vaccines. BMC Infect Dis. 2020, 20: 279. Published online 2020 Apr 15 https://doi.org/10.1186/s12879-020-04998-5

Johansen, T.B., Astrup, E., Jore, S., Nilssen, H., Dahlberg, B.B., Klingenberg, C., Berg, A.S., Greve-Isdah, l.M. (2020) Infection prevention guidelines and considerations for paediatric risk groups when reopening primary schools during COVID-19 pandemic, Norway, April 2020.Euro Surveill. 2020 Jun,25(22):2000921. PMID: 32524956 https://doi.org/10.2807/1560-7917.ES.2020.25.22.2000921

Jøraholmen, M.W., Bhargava, A., Julin, K., Johannessen, M., Skalko-Basnet, N. (2020) The Antimicrobial Properties of Chitosan Can be  Tailored by Formulation. Marine Drugs 2020 ,Volum 18., https://doi.org/10.3390/md18020096

Jøraholmen, M.W., Johannessen, M., Gravningen, K., Puolakkainen, M., Acharya, G., Basnet, P., Škalko-Basnet, N. (2020) Liposomes-In-Hydrogel Delivery System Enhances the Potential of Resveratrol in Combating Vaginal Chlamydia Infection Pharmaceutics. 2020 Dec, 12(12): 1203. Published online 2020 Dec 11. https://doi.org/10.3390/pharmaceutics12121203

Jøraholmen, M.W., Bhargava, A., Julin, K., Johannessen, M., Škalko-Basnet, N. (2020) The Antimicrobial Properties of Chitosan Can Be Tailored by Formulation Mar Drugs. 2020 Feb, 18(2): 96. Published online 2020 Jan 31. https://doi.org/10.3390/md18020096

Keller, L.J., Lentz, C.S., Chen, Y.E., Metivier, R.J., Weerapana, E., Fischbach, M.A., Bogyo, M. (2020) Characterization of Serine Hydrolases Across Clinical Isolates of Commensal Skin Bacteria Staphylococcus epidermidisUsing Activity-Based Protein Profiling. ACS Infect Dis. 2020 May 8,6(5):930-938. https://doi.org/10.1021/acsinfecdis.0c00095

Klingenberg, C. (2020) Risk of bias in study on early antibiotics and necrotizing enterocolitis.J Pediatr. 2020 Jul 3:S0022-3476(20)30847-7. dOnline ahead of print. PMID: 32629011 https://doi.org/10.1016/j.jpeds.2020.07.004

Kunttu, P., Pasanen, H., Rämä, T., Kulju, M., Kunttu, S-A., Kotiranta, H. (2020). Diversity and ecology of aphyllophoroid fungi on driftwood logs on the shores of the Baltic Sea. Nordic Journal of Botany (NJB) 2020 Volum 38.(4). https://doi.org/10.1111/njb.02735

Lang, A., Klingenberg, C., Greve-Isdahl, M., Andresen, J.H. (2020) Neonates should be with their mothers, even if the mother has COVID-19. Tidsskr Nor Laegeforen. 2020 Mar 26,140(6). doi: 10.4045/tidsskr.20.0242. Print 2020 Apr 21. PMID: 32321214 

Lavizzari, A., Klingenberg, C., Profit, J., Zupancic, J.A.F., Davis, A.S., Mosca, F., Bearer, C.F., Roehr, C.C. (2020) Neonates in the COVID-19 pandemic. Molloy International Neonatal COVID-19 Consortium. Pediatr Res. 2020 Aug 3Online ahead of print. PMID: 32746446 doi: 10.4045/tidsskr.20.0242

Lavizzari, A., Klingenberg, C., Profit, J., Zupancic, J.A.F., Davis, A.S., Mosca, F., Molloy, E.J., Roehr, C.C. (2020)International comparison of guidelines for managing neonates at the early phase of the SARS-CoV-2 pandemic. International Neonatal COVID-19 Consortium. Pediatr Res. 2020 Jun 15. Online ahead of print. PMID: 32541844 https://doi.org/10.1038/s41390-020-0976-5

Leiros, H-K.S., Thomassen, A.M.,Samuelsen, Ø., Flach, C.F., Kotsakis, S.D., Larsson, D.G.J. (2020). Structural insights in to the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10. FEBS Open Bio. 10(9):1821-1832. https://doi.org/10.1002/2211-5463.12935. Epub 2020 Aug 8.

Pain, M., Wolden, R., Jaén-Luchoro, D., Salvà-Serra, F., Iglesias, B.P., Karlsson, R., Klingenberg, C., Cavanagh, J.P. (2020)Staphylococcus borealis sp. nov., isolated from human skin and blood. Int J Syst Evol Microbiol. 2020 Dec,70(12):6067-6078. https://doi.org/10.1099/ijsem.0.004499

Paulsen, M.H., Ausbacher, D., Bayer, A., Engquist, M., Hansen, T., Haug, T., Anderssen, T., Andersen, J.H., Ericson Sollid, J.U. & Strøm, M.B. (2019). Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL – CARBA producing multi-resistant bacteria, effect of halogenation, lipophilicity and cationic character. European Journal of Medicinal Chemistry, 183:111671-111682. https://doi.org/10.1016/j.ejmech.2019.111671

Pedersen, T., Tellevik, M.G., Kommedal, Ø., Lindemann, P.C., Moyo, S.J., Janice, J., Blomberg, B., Samuelsen, Ø., Langeland, N. (2020). Horizontal plasmid transfer among Klebsiella pneumoniaeisolates is the key factor for dissemination of extended-spectrum β-lactamases among children in Tanzania. mSphere 15,5(4):e00428-20.  https://doi.org/10.1128/mSphere.00428-20

Pettersen, V.K., Arrieta, M.C. (2020) Host-microbiome intestinal interactions during early life: considerations for atopy and asthma development. Curr Opin Allergy Clin Immunol. 2020 Apr,20(2):138-148. doi: 10.1097/ACI.0000000000000629. PMID: 32004178

Rodríguez-Beltrán, J., Sørum, V., Toll-Riera, M., Vega, C. de la, Peña-Miller, R., Millán, Á.S. (2020)   Genetic dominance governs the evolution and spread of mobile genetic elements in bacteria. Proc Natl Acad Sci. 2020 Jul  7,117(27):15755–62. https://doi.org/10.1073/pnas.2001240117

Rørtveit, G., Simonsen, G.S. (2020). The Primary Care Perspective on the Norwegian National Strategy against Antimicrobial Resistance. Antibiotics (Basel) 2020 Sep, 9(9): 622.  https://doi.org/10.3390/antibiotics9090622

Samuelsen, Ø., Åstrand, O.A.H, Fröhlich, C., Heikal, A., Skagseth, S., Carlsen, T.J.O., Leiros, H-K.L., Bayer, A., Schnaars, C,, Kildahl-Andersen, G., Lauksund, S., Finke, S., Huber, S., Gjøen, T., Andresen, A.M.S., Økstad, O.A., Rongved, P. (2020) ZN148 – a modular synthetic metallo-β-lactamase inhibitor reverses carbapenem resistance in Gram-negative pathogens in vivo. Antimicrob Agents Chemother. 2020 May 21,64(6):e02415-19. https://doi.org/10.1128/AAC.02415-19. Print 2020 May 21.

Sanabria, A., Hjerde, E., Johannessen, M., Sollid, J.E., Simonsen, G.S., Hanssen, A-M. (2020). Shotgun-Metagenomics on Positive Blood Culture Bottles Inoculated With Prosthetic Joint Tissue: A Proof of Concept Study. Front Microbiol. 2020, 11: 1687. Published online 2020 Jul 17. https://doi.org/10.3389/fmicb.2020.01687

Schneider, Y. K-H., Jenssen, M., Isaksson, J., Østnes Hansen, K., Andersen, J.H., Hansen, E. (2020). Bioactivity of Serratiochelin A, a Siderophore Isolated from a Co-Culture of Serratia sp. and Shewanella sp.. Microorganisms 2020, Volum 8 (7). ISSN 2076-2607.s 1 - 17.s https://doi.org/10.3390/microorganisms8071042

Selvarajan, V., Obuobi, S.A.O, Pui, L., Rachel, E. (2020) Silica Nanoparticles—A Versatile Tool for the Treatment of Bacterial Infections. Frontiers in Chemistry 2020, Volum 8. (602)

Solstad, R.G., Johansen, C., Stensvåg, K., Strøm, M.B., Haug, T. (2020) Structure-activity relationship studies of shortened analogues of the antimicrobial peptide EeCentrocin 1 from the sea urchin Echinus esculentus. J. Pep. Sci. 2020,26:e3233. DOI:10.1002/psc.3233. https://doi.org/10.1002/psc.3233

Størdal, K., Bakken, I.J., Greve-Isdahl, M., Klingenberg, C., Helland, E., Nystad, W., Hjellvik, V., Gulseth, H.L. (2020) SARS-CoV-2 in children and adolescents in Norway: confirmed infection, hospitalisations and underlying conditions. Tidsskr Nor Laegeforen. 2020 Jun 24,140(11). doi: 10.4045/tidsskr.20.0457. Print 2020 Aug 18. PMID: 32815353

Ternullo, S., Schulte Werning, L., Holsæter, A.M., Skalko-Basnet, N. (2020). Curcumin-In-Deformable Liposomes-In-Chitosan Hydrogel as a Novel Wound Dressing. Pharmaceutics 2020 ,Volum 12.(1) https://doi.org/10.3390/pharmaceutics12010008

Thaulow, C.M., Lindemann, P.C., Klingenberg, C., Berild, D., Salvesen, B.H., Myklebust T.Å., Harthug, S. (2020) Epidemiology and Antimicrobial Susceptibility of Invasive Bacterial Infections in Children-A Population-Based Study From Norway. Pediatr Infect Dis J. 2020 Dec 24,Publish Ahead of Print. doi: 10.1097/INF.0000000000003013. Online ahead of print.PMID: 33298760

van Tilburg Bernardes, Pettersen, V.C., Gutierrez, M.W., Laforest-Lapointe, I., Jendzjowsky, N.G., Cavin, J-B., Vicentini, F.A., Keenan, C.M., Ramay, H.R., Samara, J., MacNaughton, W.K., Wilson, R.J.A., Kelly, M.M., McCoy,K.D.,  Sharkey, K.A.,  Arrieta, M-C. (2020) Intestinal fungi are causally implicated in microbiome assembly and immune development in mice Nat Commun. 2020, 11: 2577. Published online 2020 May 22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244730/

Vatne A, Klingenberg C, Øymar K, Rønnestad AE, Manzoni P, Rettedal S. Reduced Antibiotic Exposure by Serial Physical Examinations in Term Neonates at Risk of Early-onset Sepsis. Pediatr Infect Dis J. 2020 May,39(5):438-443. PMID: 32301920 https://doi.org/10.1097/INF.0000000000002590

Vimberg V, Cavanagh JP, Novotna M, Lenart J, Nguyen Thi Ngoc B, Vesela J, Pain M, Koberska M, Balikova Novotna G. Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants.Antimicrob Agents Chemother. 2020 Oct 20,64(11):e00666-20. Print 2020 Oct 20. PMID: 32816732 https://doi.org/10.1128/AAC.00666-20

Wirth, T., Bergot, M., Rasigade, J.P., Pichon, B., Barbier, M., Martins-Simoes, P., Jacob, L., Pike R., Tissieres, .P, Picaud JC, Kearns, A., Supply, P., Butin, M., Laurent, F., International Consortium for Staphylococcus capitis neonatal sepsis, ESGS Study Group of ESCMID (Klingenberg C) (2020) Niche specialization and spread of Staphylococcus capitis involved in neonatal sepsis. Nat Microbiol. 2020 May,5(5):735-745. Epub 2020 Apr 27. PMID: 32341568 https://doi.org/10.1038/s41564-020-0676-2

Wolden, R., Pain, M., Karlsson, R., Karlsson, A., Aarag Fredheim, E.G., Cavanagh, J.P. (2020) Identification of surface proteins in a clinical Staphylococcus haemolyticus isolate by bacterial surface shaving. BMC Microbiol. 2020 Apr 7,20(1):80. PMID: 3226483https://doi.org/10.1186/s12866-020-01778-8

Zykov, I.N., Frimodt-Møller, N., Småbrekke, L., Sundsfjord, A., Samuelsen, Ø. (2020) Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model. 2020 Feb,55(2):105851. https://doi.org/10.1016/j.ijantimicag.2019.11.008.

2019

Achten NB, Klingenberg C, Benitz WE, Stocker M, Schlapbach LJ, Giannoni E, Bokelaar R, Driessen GJA, Brodin P, Uthaya S, van Rossum AMC, Plötz FB. Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety: A Systematic Review and Meta-analysis. JAMA Pediatr. 2019, 173(11):1032-1040

Agyepong N, Govinden U, Owusu-Ofori A, Amoako DG, Allam M, Janice J, Pedersen T, Sundsfjord A, Essack S. Genomic characterization of multidrug-resistant ESBL-producing Klebsiella pneumoniae isolated from a Ghanaian teaching hospital. Int J Infect Dis. 2019; 85:117123. 

Cavanagh JP, Askarian F, Pain M, Bruun JA, Urbarova I, Wai SN, Schmidt F, Johannessen M. Proteome profiling of secreted and membrane vesicle associated proteins of an invasive and a commensal Staphylococcus haemolyticus isolate.  Data Brief. 2019 Jan 11;22:914-919. 

Granslo, Hildegunn Norbakken; Aarag, Elizabeth; Esaiassen, Eirin; Christophersen, Lars; Jensen, Peter Østrup; Mollnes, Tom Eirik; Moser, Claus; Flægstad, Trond; Klingenberg, Claus; Cavanagh, Jorunn Pauline. The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 2019 ;Volum 127.(6) s. 475483.

Hagestad, Ole Christian; Andersen, Jeanette hammer; Altermark, Bjørn; Hansen, Espen; Rämä, Teppo. Cultivable marine fungi from the Arctic Archipelago of Svalbard and their antibacterial activity. Mycology: An International Journal on Fungal Biology 2019. 

Jarlier, Vincent; Högberg, Liselotte Diaz; Heuer, Ole E.; Campos, Josó; Eckmanns, Tim; Giske, Christian G.; Grundmann, Hajo; Johnson, Alan P.; Kahlmeter, Gunnar; Monen, Jos; Pantosti, Annalisa; Rossolini, Gian Maria; van de Sande-Bruinsma, Nienke; Vatopoulos, Alkiviadis; Żabicka, Dorota; Žemličková, Helena; Monnet, Dominique L.; Simonsen, Gunnar Skov. Strong correlation between the rates of intrinsically antibiotic-resistant species and the rates of acquired resistance in Gram-negative species causing bacteraemia, EU/EEA, 2016. Eurosurveillance 2019; Volum 24 (33). ISSN 1025-496X.s 1 - 10. 

Jøraholmen, May Wenche; Basnet, Purusotam; Tostrup, Mia Jonine; Moueffaq, Sabrin; Skalko-Basnet, Natasa. Localized Therapy of Vaginal Infections and Inflammation: Liposomes-InHydrogel Delivery System for Polyphenols. Pharmaceutics 2019; Volum 11 (2). ISSN 1999-4923.s 1 - 19.s 

Littmann J, Simonsen GS. Antimicrobial resistance is a super wicked problem. Tidsskr Nor Laegeforen. 2019 Oct 31;139(16).

Pain M, Hjerde E, Klingenberg C, Cavanagh JP. Comparative Genomic Analysis of Staphylococcus haemolyticus Reveals Key to Hospital Adaptation and Pathogenicity. Front Microbiol. 2019 Sep 10;10:2096.

Paulsen MH, Ausbacher D, Bayer A, Engqvist M, Hansen T, Haug T, Anderssen T, Andersen JH, Sollid, JUE, Strøm MB Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character. European Journal of Medicinal Chemistry 2019 ;Volum 183. s. 111671-111682

Sanabria A, Røkeberg MEO, Johannessen M, Sollid JE, Simonsen GS, Hanssen AM. Culturing periprosthetic tissue in BacT/Alert® Virtuo blood culture system leads to improved and faster detection of prosthetic joint infections.  BMC Infect Dis. 2019 Jul 10;19(1):607. 

Solstad RG, Johansen C, Stensvåg K, Strøm MB, Haug T. Structure‐activity relationship studies of shortened analogues of the antimicrobial peptide EeCentrocin 1 from the sea urchin Echinus esculentus. Journal of Peptide Science 2019 ;Volum 26.(2), 

Sovershaeva E, Kranzer K, Mchugh G, Bandason T, Majonga ED, Usmani OS, Rowland-Jones S, Gutteberg T, Flægstad T, Ferrand RA, Odland JØ. History of tuberculosis is associated with lower exhaled nitric oxide levels in HIV-infected children. AIDS. 2019 Sep 1;33(11):1711-1718.

Svendsen, J.S.M., Grant, T.M., Rennison, D., Brimble, M.A., Svenson, J., Very Short and Stable Lactoferricin-Derived Antimicrobial Peptides: Design Principles and Potential Uses , Accounts of Chemical Research  2019, 52, 3, 749-759 

Syre, Heidi; Hetland, Marit; Bernhoff, Eva; Bollestad, Marianne; Grude, Nils; Simonsen, Gunnar Skov; Löhr, Iren Høyland. Microbial risk factors for treatment failure of pivmecillinam in community‐acquired urinary tract infections caused by ESBL‐producing Escherichia coli. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 2019. ISSN 0903-4641.s 1 - 10.s

Ternullo, Selenia; Gagnat, Eivind; Julin, Kjersti; Johannessen, Mona; Basnet, Purusotam; Vanić, Željka; Skalko-Basnet, Natasa. Liposomes augment biological benefits of curcumin for multitargeted skin therapy. European journal of pharmaceutics and biopharmaceutics 2019; Volum 144. ISSN 0939-6411.s 154 - 164.s

Vanic, Zeljka; Rukavina, Zora; Manner, Suvi; Fallarero, Adyary; Uzelac, Lidija; Kralj, Marijeta; Amidzic Klaric, Danijela; Bogdanov, Anita; Raffai, Timea; Virok, Deszo Peter; Filipovic-Grcic, Jelena; Skalko-Basnet, Natasa. Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections. International Journal of Nanomedicine 2019; Volum 14. ISSN 1176-9114.s 5957 - 5976.s 

Jonina Gudmundsdottir from the MicroPOP group has been selected by European Society of Clinical Microbiology and Infectious Diseases (ESCMID) as  one of “30 outstanding scientists 30 years of age or younger” to celebrate the 30th European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Paris this April. Selected articipants will actively participate on social media, especially Twitter, during the congress, and they are also invited to submit a scientific abstract for inclusion in the ECCMID 2020 Abstract Programme. The congress is expected to gather more than 13000 participants. Congratulations, Jonina.

https://www.eccmid.org/congress_information/30_under_30/

https://www.eccmid.org/